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 APD  Vol.9 No.2 , May 2020
Two Cases of Parkinson’s Disease for Which Dental Treatment Was Effective
Abstract: The purpose of this study is to document the improvement observed in two cases of Parkinson’s disease (PD) after dental treatment. The first subject is a man in his 60s with severe Parkinson’s disease; medication has not been very effective in this case. Prior to treatment, he was unable to stand without support due to rigidity. Just after removing as much of the dental infection as possible, he was able to walk, albeit slowly, and as a result of continuing treatment, one month later, the symptoms had significantly improved. The second subject is a woman in her 40s, who became aware of joint stiffness seven years ago, and was later diagnosed with PD independently at three hospitals. Her main symptoms were rigidity, knee pain, and speech disorder. The dopamine medication worked well against rigidity, but the symptoms reappeared after the medication stopped working. Her condition was significantly improved just after one tooth with an apical lesion was extracted. Although the underlying mechanism has not been clarified, I hypothesize that, at least in these cases, negative signals that passed through the trigeminal nerve to the midbrain affected predominantly the dopaminergic neurons in the substantia nigra of the midbrain. Removal of the harmful signals from the oral area resulted in normalization of the substantia nigra. Further research should be promoted with dental and medical cooperation.
Cite this paper: Fujii, Y. (2020) Two Cases of Parkinson’s Disease for Which Dental Treatment Was Effective. Advances in Parkinson's Disease, 9, 13-19. doi: 10.4236/apd.2020.92002.
References

[1]   Lees, A., Hardy, J. and Revesz, T. (2009) Parkinson’s Disease. Lancet, 373, 2055-2066.
https://doi.org/10.1016/S0140-6736(09)60492-X

[2]   Parkinson’s Disease Foundation. http://www.pdf.org/about_pd

[3]   Nord, M., Zsigmond, P., Kullman, A., Arstrand, K. and Dizdar, N. (2010) The Effect of Peripheral Enzyme Inhibitors on Levodopa Concentrations in Blood and CSF. Movement Disorders, 25, 363-367.
https://doi.org/10.1002/mds.22613

[4]   Murray, A.M., Bennett, D.A., Mendes de Leon, C.F., Beckett, L.A. and Evans, D.A. (2004) A Longitudinal Study of Parkinsonism and Disability in a Community Population of Older People. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59, 864-870.
https://doi.org/10.1093/gerona/59.8.M864

[5]   Jankovic, J. (2008) Parkinson’s Disease: Clinical Features and Diagnosis. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 368-376.
https://doi.org/10.1136/jnnp.2007.131045

[6]   Caballol, N., Martí, M.J. and Tolosa, E. (2007) Cognitive Dysfunction and Dementia in Parkinson Disease. Movement Disorders, 22, 358-366.
https://doi.org/10.1002/mds.21677

[7]   Fujii, Y. (2016) Two Cases of Severe Dementia Showing Dramatic Improvement after Denture Placement. Advances in Alzheimer’s Disease, 5, 46-52.
https://doi.org/10.4236/aad.2016.52004

[8]   Yoshiaki, O. (1993) Bi-Digital O-Ring Test for Imaging and Diagnosis of Internal Organs of a Patient. US Patent 5188107. http://academic.reed.edu/economics/parker/f11/354/pat/o-ring.pdf

[9]   http://bdort.org/

[10]   Rabey, J.M. and Hefti, F. (1990) Neuromelanin Synthesis in Rat and Human Substantia Nigra. Journal of Neural Transmission. Parkinson’s Disease and Dementia Section, 2, 1-14.
https://doi.org/10.1007/BF02251241

[11]   Kim, S.J., Sung, J.Y., Um, J.W., Hattori, N., Mizuno, Y., Tanaka, K., Paik, S.R., Kim, J. and Chung, K.C. (2003) Parkin Cleaves Intracellular Alpha-Synuclein Inclusions via the Activation of Calpain. Journal of Biological Chemistry, 278, 41890-41899.
https://doi.org/10.1074/jbc.M306017200

[12]   Fujii, Y. (2012) Do Dental Implants Cause Scoliosis? Case Report. Personalized Medicine Universe, 1, 79-80.
https://doi.org/10.1016/j.pmu.2012.05.012

[13]   Fujii, Y. (2015) Orthodontic Treatment to Improve Hip Joint Mobility and Balance. Journal of Dentist, 3, 29-32.
https://doi.org/10.12974/2311-8695.2015.03.01.5

[14]   Fujii, Y. (2017) Severe Dermatitis Might Be Caused by a Cross-Reaction between Nickel and Palladium and Dental Amalgam Resolved Following Removal of Dental Restoration. Clinical Case Reports, 5, 795-800.
https://doi.org/10.1002/ccr3.938

[15]   Fujii, Y. (2019) Evaluation of a Mouthguard Customized Using the Occlusal Position during Maximal Grip Strength to Improve Sports Performance. A Case Report. Case Reports in Clinical Medicine, 8, 147-151.
https://doi.org/10.4236/crcm.2019.86017

 
 
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