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 CSTA  Vol.9 No.2 , May 2020
Synthesis and Crystal Structure Studies of Mitomycin C Dihydrate
Abstract: The absolute configuration of mitomycin C was determined by X-ray single crystal diffraction (CuKα), and a new crystalline dihydrate of mitomycin C had been prepared. The experiment result provides a definitive answer to the real absolute configuration of mitomycin C and may put an end to the dispute that baffles researchers for decadesAt the same time, some contentious structures about the mitomycin C in American Pharmacopoeia USP36-NF31Chinese pharmacopoeia 2015 edtion and numbers of literatures are marked. The absolute configuration is also verified by 1D (1H and 13C) and 2D (HSQC, HMBC, 1H-1COSY and NOESY) NMR studies indirectly. Powder X-ray diffraction (PXRD) pattern of the mitomycin C dihydrate is similar to that calculated for it, which suggests that the purity of sample is excellent.
Cite this paper: Feng, Y. , Chen, Y. , Ren, Y. , Zhang, H. and Cao, S. (2020) Synthesis and Crystal Structure Studies of Mitomycin C Dihydrate. Crystal Structure Theory and Applications, 9, 13-21. doi: 10.4236/csta.2020.92002.
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