OJMP  Vol.9 No.2 , April 2020
Psychobiological Model of Volition— Implications for Mental Disorders
Abstract: A new psychobiological model of volitive processes and its implications for the etiopathology of mental disorders is proposed. The model is based on five elementary volitive processes. These are the volition to act; the volition to self-instrumentalize; the volition to program intentions, the volition to generate realities; and the volition to permanent existence. Imbalances in information processing in tripartite synapses and their network may be responsible for dysfunctions of self-instrumentalization. It is suggested that the volition to permanent existence unconsciously works in mental disorders, but the volition to intentional programming of realities and the volition to generate realities by communication with subjects and objects in their environment are impaired. In depression, the volition to act is constrained by hyperintentional programs that are non-feasible in the environment. In mania volitive processes are totally oriented on events in the environment without any goal-directed pro-gramming. Dysfunctions of volitive processes in schizophrenia are fun-damentally caused by severe impairments of self-instrumentalization. As shown in tripartite synapses a gap between sensory information pro-cessing in the neuronal network and the inner glial networks causes the inability of schizophrenics to distinguish between the self and the other. In delusions, the destiny for communication becomes staged as pseu-do-communication. Together, the study outlines a new model of volitive processes and deduces dysfunctions responsible for communication pa-thology and abnormal reality experiences of patients with mental disor-ders.
Cite this paper: Mitterauer, B. (2020) Psychobiological Model of Volition— Implications for Mental Disorders. Open Journal of Medical Psychology, 9, 50-69. doi: 10.4236/ojmp.2020.92005.

[1]   James, W. (1890) The Principles of Psychology. Holt, New York.

[2]   Prinz, W., Dennett, D. and Sebanz, N. (2006) Toward a Science of Volition. In: Sebanz, N. and Prinz, W., Eds., Disorders of Volition, The MIT Press, Cambridge, MA, 1-16.

[3]   Jeannerod, M. (2006) From Volition to Agency: The Mechanism of Action Recognition and Its Failures. In: Sebanz, N. and Prinz, W., Eds., Disorders of Volition, The MIT Press, Cambridge, MA, 175-192.

[4]   Smirnov, D., Lachat, F., Peltola, T., Lahnakoski., et al. (2017) Brain-to-Brain Hyper- classification Reveals Action-Specific Motor Mapping of Observed Actions in Humans. PLoS ONE, 12, e0189508.

[5]   Custers, R. and Aarts, H. (2010) The Unconscious Will: How the Pursuit of Goals Operates Outside of Conscious Awareness. Science, 329, 47-50.

[6]   Augustinus (2001) De trinitate. Meiner, Hamburg.

[7]   Baer, W. (2010) Introduction to the Physics of Consciousness. The Journal of Consciousness Studies, 17, 165-191.

[8]   Baer, W. (2019) Conscious Action Theory. An Introduction to the Event-Oriented World View. Routledge, London.

[9]   Günther, G. (1976) Cognition and Volition. A Contribution to a Theory of Subjectivity. In: Kanitscheider, B., Ed., Sprache und Erkenntnis, AMOE, Innsbruck, 235-242.

[10]   Kugler, N., Kelso, J.A.S. and Turvey, M.T. (1980) On the Concept of Coordinative Structures as Dissipative Structures. I. Theoretical Lines of Convergence. In: Stelmach, G.E. and Requin, J., Eds., Tutorials in Motor Behavior, North-Holland Publishing, New York, 1-47.

[11]   Maturana, H.R. (1970) Biology of Cognition. Biological Computer Laboratory, Report No. 9.0, University of Illinois Urbana-Champaign, Urbana, IL.

[12]   Varela, F.G. (19749 A Calculus for Self-Reference. Heneidia, Costa Rica.

[13]   Mitterauer, B. (2009) Narziss und Echo. Ein psychobiologisches Modell der Depression. Springer, Vienna.

[14]   Kelso, J.A.S. and Tuller, B. (1984) A Dynamical Basis of Action Systems. In: Gazzaniga, M.S., Ed., Handbook of Cognition Neuroscience, Plenum, New York, 321-356.

[15]   Moore, A., Zhou, W., Sirois, C., et al. (2014) Connexin Hemichannels Contribute to Spontaneous Electrical Activity in the Human Fetal Cortex. Proceedings of the National Academy of Sciences of the United States of America, 111, E3919-E3928.

[16]   Nimmerjahn, A., Kirchoff, F., Kerr, J.N.D. and Helmchen, F. (2004) Sulforhodamine 101 as a Specific Marker of Astroglia in the Neocortex in Vivo. Nature Methods, 1, 31-37.

[17]   Kelso, J.A.S., Holt, K., Rubin, P. and Kugler, P.N. (1981) Patterns of Human Interlimb Coordination Emerge from the Properties of Non-Linear Oscillations: Theory and Data. Journal of Motor Behavior, 13, 226-261.

[18]   Mitterauer, B.J. (2013) The Proemial Synapse: Consciousness-Generating Glial-Neu-ronal Units. In: Pereira, A. and Lehmann, D., Eds., The Unity of Mind, Brain and World, Cambridge University Press, Cambridge, 233-264.

[19]   Basso, D. and Belardinelli, M.O. (2006) The Role of the Feed Forward Paradigm in Cognitive Psychology. Cognitive Processing, 7, 73-88.

[20]   Koch, C. (2012) Modular Biological Complexity. Science, 337, 531-532.

[21]   Mitterauer B. (1998) An Interdisciplinary Approach towards a Theory of Consciousness. Bio Systems, 45, 99-121.

[22]   Morgan, A. and Piccinini, G. (2018) Towards a Cognitive Neuroscience of Intentionality. Minds and Machines, 28, 119-139.

[23]   Mitterauer, B. (2007) Where and How Could Intentional Programs Be Generated in the Brain? A Hypothetical Model Based on Glial-Neuronal Interactions. Bio Systems, 88, 101-112.

[24]   Sosinsky, G.E., Gaietta, G.M. and Giepmans, B.N.G. (2009) Gap Junction Morphology and Dynamics in Situ. In: Harris, L.H. and Locke, D., Eds., Connexins, Human Press, New York, 241-261.

[25]   Baer, W. (2015) On the Necessity of Including the Observer in Physical Theory. Cosmos and History. The Journal of Natural and Social Philosophy, 11, 160-174.

[26]   Robertson, J.M. (2013) Astrocyte Domains and the Three-Dimensional and Seamless Expression of Consciousness and Explicit Memories. Medical Hypotheses, 81, 1017-1024.

[27]   Mitterauer, B.J. (2012) Qualitative Information Processing in Tripartite Synapses: A Hypothetical Model. Cognitive Computation, 4, 181-194.

[28]   Mitterauer, B.J. (2015) Model of the Reticular Formation of the Brainstem Based on Glial-Neuronal Interactions. Cognitive Computation, 7, 64-73.

[29]   Günther, G. (1962) Cybernetic Ontology and Transjunctional Operations. In: Yovits, M.C., Jacobi, G.T. and Goldstein, G.D., Eds., Selforganizing Systems, Spartan Books, Washington DC, 313-393.

[30]   Hirrlinger, J., Hülsmann, S. and Kirchoff, F. (2004) Astroglial Processes Show Spontaneous Motility of Active Synaptic Terminals in Situ. European Journal of Neuroscience, 20, 2235-2239.

[31]   Mitterauer, B.J. (2015) Tripartite Synapses and the Glial Network. Quantum Biosystems, 1, 1-9.

[32]   Parri, R. and Crunelli, V. (2001) Astrocytes Target Presynaptic NMDA Receptors to Give Synapses a Boost. Nature Neuroscience, 10, 271-273.

[33]   Mitterauer, B. (2007) Therapie von Entscheidungskonflikten. Das Volitronics-Prinzip. Springer, Vienna.

[34]   Mitterauer, B. (2003) Das Prinzip des Narzissmus. Modell der polyontologischen Selbstreferenz. Grundlagenstudien aus Kybernetik und Geisteswissenschaft, 44, 82-87.

[35]   Freud, S. (1913) Totem and Taboo. The Standard Edition of the Complete Psychological Works of Sigmund Freud, Volume 13, Hogarth Press, London

[36]   Masserman, J.H. (1955) The Practice of Dynamic Psychiatry. Saunders, Philadelphia, PA.

[37]   American Psychiatric Association (2013) Diagnostic and Statistical Manual of Mental Disorders. 5th Edition, APA, Washington DC.

[38]   Mitterauer, B.J. (2018) Towards a Comprehensive Psychobiological Model of Major Depressive Disorder. Open Journal of Depression, 7, 31-49.

[39]   Bibring, E. (1953) The Mechanism of Depression In: Greenacre, P., Ed., Affective Disorders, International Universities Press, New York, 13-28.

[40]   Kalis, A., Mojzisch, A., Schweizer, T.S. and Kaiser, S. (2008) Weakness of Will, Akrasia and Neuropsychiatry of Decision Making: An Interdisciplinary Perspective. Cognitive, Affective and Behavioral Neuroscience, 8, 402-417.

[41]   Mitterauer, B. (2002) Communication and Anti-Communication in Suicidal Behavior. In: De Riso, S. and Sarchiapone, M., Eds., Il Suicido. Aspetti biologici, psicologici e sociali, Masson, Milano, 97-105.

[42]   Platon (2006) Symposion. Reclam.

[43]   Jamison, K.R. (1995) Manic-Depressive Illness and Creativity. Scientific American, 272, 62-67.

[44]   Öngür, D., Jensen, J.E., Prescot, A.P., et al. (2008) Abnormal Glutamatengic Neurotransmission and Neuronal Glial Interactions in Acute Mania. Biological Psychiatry, 64, 718-726.

[45]   Mellerup, E. and Kristensen, F. (2004) Mania as a Dysfunction of Reentry: Application of Edelman’s and Tononi’s hypothEsis for Consciousness to Psychiatric Disorder. Medical Hypothesis, 63, 464-466.

[46]   Mitterauer, B.J. (2006) Pseudoomnipotence: A Model of the Manic Syndrome. In: Kotlar, M.B., Ed., New Developments in Mania Research, Nova Science Publishers, New York, 161-178.

[47]   Northoff, G., Magioncalda, P., Martino, H., et al. (2018) Too Fast or Too Slow? Time and Neuronal Variability in Bipolar Disorder: A Combined Theoretical and Empirical Investigation. Schizophrenia Bulletin, 4, 54-64.

[48]   Moskalewicz, M. and Schwartz, M.A. (2018) Temporal Experience in Mania. In: Phenomenology and the Cognitive Sciences, Springer, New York.

[49]   Hales, R.E., Yudofsky, S.C. and Tabbott, J.S. (1999) The American Psychiatric Press Textbook of Psychiatry. The American Psychiatric Press, Washington DC.

[50]   Kraeplin, E. (1919) Dementia Praecox and Paraphrenia. UK Livingston, Edinburgh

[51]   Bleuler, E. (1950) Dementia Praecox or the Group of Schizophrenias. International Universities Press, New York.

[52]   Foussias, G. and Remington, G. (2010) Negative Symptoms in Schizophrenia: Avolition and Occam’s Razor. Schizophrenia Bulletin, 36, 359-369.

[53]   Amodio, A., Quarantelli, M., Mucci, A., et al. (2018) Avolition-Apathy and White Matter Connectivity in Schizophrenia: Reduced Fractional Anisotropy between Amygdala and Insular Cortex. Clinical EEG and Neuroscience, 49, 55-65.

[54]   Frith, C. (2006) Interpersonal Factors in the Disorders of Volition Associated with Schizophrenia. In: Sebanz, N. and Prinz, W., Eds., Disorders of Volition, The MIT Press, Cambridge, MA, 233-247.

[55]   Mitterauer, B.J. (2014) Pathophysiology of Schizophrenia Based on Impaired Glial-Neuronal Interactions. Open Journal of Medical Psychology, 3, 126-140.

[56]   Mitterauer, B.J. (2019) Disintegration of the Astroglial Organization May Underlie the Loss of Reality Comprehension in Schizophrenia: A Hypothetical Model. Open Journal of Medical Psychology, 8, 15-35.

[57]   Verkhratsky, A., Rodriguez, J.J. and Steardo, L. (2014) Astrogliopathology: A Central Element of Neuropsychiatric Diseases? Neuroscientist, 20, 576-588.

[58]   Keromnes, G., Motillon, T, Coulon, N., et al. (2018) Self-Other Recognition Impairments in Individuals with Schizophrenia: A New Experimental Paradigm Using a Double Mirror. NPJ Schizophrenia, 4, 24.

[59]   Mitterauer, B. (2010) Synaptic Imbalances in Endogenous Psychoses. Bio Systems, 100, 113-121.

[60]   Roux, L., Benchenane, K., Rotstein, K., et al. (2011) Plasticity of Astroglial Networks in Olfactory Glomeruli. Proceedings of the National Academy of Sciences of the United States of America, 108, 18442-18446.

[61]   Mitterauer, B.J. (2003) The Eternal Now: Towards an Interdisciplinary Theory of Schizophrenia. Journal of the BWW Society.

[62]   Mitterauer, B., Rothuber, H., Bitterlich, W. and Buschmann, W. (2006) Index der schizophrenen Dysintentionalität. Psychopraxis, 2, 12-17.

[63]   Berk, M. and Berk, L. (2017) Cognition in Psychiatric Disorders: From Models to Management. The Lancet, 4, 173-175.

[64]   Goschke, T. (2014) Dysfunctions of Decision-Making and Cognitive Control as Transdiagnostic Mechanism of Mental Disorders: Advances, Gaps and Needs in Current Research. International Journal of Methods in Psychiatric Research, 1, 41-57.

[65]   Verkhratsky, A. and Nedergaard, M. (2018) Physiology of Astroglia. Physiological Reviews, 98, 239-289.

[66]   Pereira Jr., A. (2017) Astroglial Hydro-Ionic Waves Guided by the Extracellular Matrix: An Exploratory Model. Journal of Integrative Neuroscience, 16, 1-16.

[67]   Pereira Jr., A. (2018) The Projective Theory of Consciousness: From Neuroscience to Philosophical Psychology. Trans/Form/Ação, 41, 199-232.