A goiter is a localized or generalized enlarged thyroid body. It is usually cervical but may have intrathoracic development by exceeding the upper opening of the chest . On the radiological level goiter is when the thyroid volume measured in ultrasound is 18 ml in women, 20 ml in men . Thyroid surgery has a special place in the treatment of multiple thyroid pathologies . Its practical realization requires a perfect mastery of the anatomy of the cervical region. It consists of the partial or total removal of the thyroid gland. There are several varieties ranging from lobectomy to lobo-isthmectomy, isthmectomy and total thyroidectomy . The haunting of the cervical surgeon is the management of cancer pathologies and the prevention of complications related to this surgery. Currently this morbidity is reduced thanks to better medical and endocrine preparation of patients as well as the use of monitoring and video surgery in the research and preservation of vasculo-nervous pedicules and glands parathyroids . The purpose of our study was to evaluate the experience of the service in the surgical management of goiters and to compare the results of our study with those of the literature.
2. Materials and Method
This was a retrospective, descriptive study carried out in the ENT and Cervico-facial Surgery Department of the Gabriel TOURE University Hospital in Bamako. We did a comprehensive sampling of all goiter cases from January 2013 to December 2018. Included in the study were the records of patients of all ages and genders, admitted into the ward and scheduled for thyroidectomy (partial or total). The non-inclusion criteria were incomplete hospitalization records. There were 19 of them. A total of 139 files were retained.
- Socio-demographic aspects (age, gender, occupation, residence);
- Clinical aspects: goiter size, palpatory data;
- Paraclinical aspects: TIRADS classification;
- Therapeutic aspects: technique and postoperative follow-up ranging from 6 to 1 year.
3.1. Hospital Frequency
In 60 months, 139 cases were collected out of 1720 patients hospitalized for surgery, representing a hospital prevalence of 8.08%.
3.2. Socio-Demographic Aspects
The female sex represented 123 cases or a sex ratio of 0.13. The average age was 46.89 years with extremes of 16 and 74 years (Figure 1). The socio-professional categories were in declining order women in the home (68.34%), Traders (10.80%), Workers (9.35%), Middle Managers (5.75%), Pupils/Students (3.60), Senior Executives (2.15%).
3.3. Clinical Aspects
The reported functional signs were tachycardia, asthenia and other signs of dysthyroidism in 59% as well as signs of compression in 24.46%. In 72 cases or 51.80% the patients consulted between 2 and 10 years of disease progression. Twenty patients or 14.39% had a history of familial goiter and 2 patients had a history of thyroid surgery. On physical examination the swelling was antero-cervical in 56.83% of cases. In 96 cases or 69.06% the glandular diameter was
Figure 1. Distribution of patients by age group.
between 5 and 9 cm. In 2 cases or 1.43% we found cervical adenopathy in the jugulo-carotid chain.
3.4. Paraclinical Aspects
Ultrasound, TSHus and fT4 were performed first-line and systematically in all of our patients. Ultrasound objectified an appearance of multinodular goiter in 106 cases or 76.26%. In 60.43% of cases the patients were RADS 3 TI classes, they were TI RADS 4A in 16 cases or 11.51% and in 2 cases or 1.43% they were RADS 4B TI classes. CT scans were performed in 3 patients, or 2.15% to specify the loco-regional extension, to look for possible lymph node invasion, and to compress or dipping the goiter. The hormonal check-up carried out systematically in all our patients found euthyroidism in 43 cases or 30.9%, hyperthyroidism in 96 cases or 69.06%, zero cases of hypothyroidism. Hormonal treatment after advice from the endocrinology department has been initiated in all patients with hyperthyroidism.
3.5. Therapeutic Appearance
Surgical indication was placed in front of a multi nodular goiter (GMN) in 106 cases or 76.26%, a single goiter in 11 cases or 7.9%, a single nodule greater than 3 cm in 17 cases or 12.23%, Basedow disease in 4 cases or 2.88% and a recurrence in one case is 0.72% (Table 1). We performed a lobo-isthmectomy in 56.11%, a total thyroidectomy in 20.14% of cases, a subtotal thyroidectomy in 20.86% of cases and total thyroidectomy with mediatino-recurrent lymphnode cure and jugulo-carotidien bilaterally in 4 cases or 2.87% (Table 2). Recurrent nerves were systematically searched and seen in all cases. Replacement therapy was indicated in all patients who underwent a total thyroidectomy. Complications recovered were 1 case of compressive hematoma, 6 cases of transient dysphonies and cough, 4 cases of definitive hypocalcemia. 1 case of recurrence, but no deaths were observed (Table 3).
3.6. Histological Aspect
For all the files studied, the anatomopathology results concluded cancer in 3 cases: 2.16% (2 cases of vesicular carcinomas and 1 case of undifferentiated carcinoma), Ridel’s thyroiditis in one case and the rest was dominated by vesicular and colloid adenoma (Table 4).
Table 1. Distribution of patients according to the indication for surgery.
Table 2. Distribution of patients according to the operative technique.
Table 3. Distribution of patients according to postoperative incidents.
Table 4. Distribution of patients according to pathological findings.
4.1. Methodological Aspects
We conducted a retrospective and descriptive study on the surgical management of goiters in the ENT Department of the Gabriel TOURE University Hospital. It lasted for 5 years (January 2013 to December 2018). Retrospectiveness has given a number of limitations to our study.
- Poor preservation of archives;
- Lack of reliable and usable data in some files during the retrospective phase;
- The change of address of patients or contact persons in Bamako Failure to meet appointments for post-operative control by some patients;
- The medium- and long-term post-operative follow-up survey was conducted using hospital record often supplemented by home visits. The phone was used to reach patients who are outside Bamako.
4.2. Hospital Frequency Aspect
In 5 years we performed 139 thyroidectomies, or 8.08% of all surgeries in the ward (n-1720). African studies on the subject have found frequencies significantly higher than our series  . This weakness in our hospital frequency could be explained by the fact that this surgery is also practiced in the various departments of visceral surgery.
4.3. Socio-Demographic Aspects
The average age of our patients was 46.89 years, which is no different statistically from that of African authors such as Ouedrago  in Burkina Faso, Dia DG  in Senegal, who were 46 years old, and 40 years respectively. In general the average age in thyroid pathology varies between 40 and 60 years  , so it is the prerogative of the young adult subject. In our study we noted a female predominance in 88.4%. This same observation has been corroborated by the literature   . Female predominance appears to show only that from puberty, which is explained by the intervention of hormonal factors, the presence of estrogen receptors on the vesicular cells whose growth they promote. In addition, estrogens reduce the activity of the iodine symporter and contribute to the depletion of thyroid iodine content. Pregnancy promotes the onset or development of goiters, due to hyperestrogenengineering, thyreostimulant activity of placental HCG, supply of iodine and hormones to the fetus, and finally to increased renal clearance of iodine .
4.4. Clinical Aspects
The consultation period varies from different studies to less than 10 years. In our series more than half of the patients had a disease progression period between 2 - 10 years. This is similar to that of some authors  . Goiter remains asymptomatic for a long time, which does not motivate consultation very early. There are also social beliefs that patients only consult when swelling becomes very troublesome by its volume or when signs of complications and compression appear or in the face of signs of dysthyroidism. The most common reason for consultation is low anterior cervical swelling. Sometimes signs of compression or signs of dysthyroidism can be noted  . In our study the reported functional signs were tachycardia, asthenia and other signs of dysthyroidism in 59% as well as signs of compression in 24.46%.
4.5. Paraclinical Aspects
Ultrasound was routinely performed in all of our patients. This is the reference test for thyroid nodule analysis, and for the detection of subclinical nodules (1 - 3 mm). Ultrasound criteria for suspicion of malignancy have been established. Recent studies have shown that several criteria taken in isolation have no formal value; in contrast, the association of several traits with a proven predictive value with the diagnosis of cancer . In our study, data from cervical ultrasound reports identified 2 suspicious nodules CLASSEs TI-RADS 4b whose histology concluded to carcinomas. CT scans allow a detailed morphological study of the intrathoracic portion of the goiter that is inaccessible to ultrasound. It will specify the lower and posterior limits of the goiter, its relationship with large thoracic cervico vessels and with the oeso-tracheal axis  . In our study it was carried out in 5 suspected cases of plunging goiter and confirmed the delipping character in the mediatin associated with deviation of the tracheal axis.
4.6. Therapeutic Aspect
Surgical techniques are related to surgical indications. So our surgical indications were multi nodular goiters with or without compression, Basedow disease, single goiters and single nodules greater than 3 cm for which we practiced either a total thyroidectomy or an isthmolobectomy. These same indications have been reported by the authors  . Today the majority of authors prefer total thyroidectomy for the surgical treatment of toxic multi nodular goiters with hormone therapy  .
4.7. Surgical Suites
In the surgical suites, the incidence of postoperative bleeding ranges from 0% to 6.5%. Male sex, the presence of cancer, the importance of the gesture, and the surgeon’s experience seem to be favourable factors  . Prevention involves preoperative control of possible dysthyroidism, intraoperative hemostasis control, and Valsalva manoeuvre to be performed in accordance with the anaesthetist, and postoperatively by early resumption of antihypertensive treatments. In our series we noted it in one case (0.7%) requiring an opening of the thyroid lodge with drainage of the hematoma and hemostasis of the vessel responsible. The incidence of recurrent, unial or bilateral impairment during a thyroidectomy is low but not zero. The risk of recurrent paralysis is present regardless of thyroid gesture. These include the type of surgery , the underlying thyropathy, the extent of the exeresis, and the volume of activity of the surgeon. The risk is increased by the presence of cancer that imposes central curage or invades adjacent structures. Other factors were mentioned: cervical hyperextension, which stretches the nerve, the number of branches dividing the recurrent, the size of the recurrent. The prevention of recurrent paralysis is both pre- and intraoperative. Neuromonitoring (NIM) used in thyroid surgery for ten years by some teams, has been developed as an aid to the intraoperative identification of the nerve, and to the elucidation of the mechanisms involved in recurrent paralysis  . We do not have NIM in our technical tray, but the objective is the effective acquisition in a short time to further minimize the risk of recurrent injury. In our study, recurrent lesions were 2.8% transient and transient. In the literature the rate of recurrent injury varies between 0.5% and 3.5%  .
The risk of postoperative hypocalcemia, transient or permanent, is increased by several factors: venous drainage of parathyroids, which is done exclusively to the thyroid for the upper parathyroids; the situation under capsular frequents in cases of large goiter or more rarely the intrathyroid situation of parathyroids, most often lower, not detectable in operative. The rate of involuntary parathyroidectomy varies from 6% to 21% depending on the authors, causing transient hypocalcemia in 50% of cases, with a risk of definitive hypocalcemia in about 2%   . In our study 4 cases (2.87%) transient hypocalcemias have been observed and treated with calcium associated with vitamin D.
4.8. Anatomopathological Aspect
Histopathology can find all aspects of transition between simple hyperplasia, adenoma, differentiated cancer and anaplastic cancer. For all the files studied, we found to the results that it was a benign pathology in 97.84% and 3 cases of malignant tumors or 2.16%. Its results are comparable to those of some authors  .
Thyroid pathology has been the subject of numerous studies, but it still poses a public health problem due to the large number of outbreaks of goitreuse endemics. Thyroid surgery is a common surgery but not devoid of complications, the most dangerous of which remain recurrent impairment and definitive hypoparathyroidism. The experience of all surgical teams in the vasculo-nerve anatomy of the neck is the best guarantor to reduce and prevent complications.
 Benbakh, M., Abou-elfadl, M., Rouadi, S., Abada, R.-L., Roubal, M. and Mahtar, M. (2016) Goitres plongeants: Expérience du service à propos de 50 cas. Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale, 133, 17-20.
 Sidibé, Y., Haidara, A.W., et al. (2019) Surgical Management of Larges Goiters in the ENT Department of CHU Mother and Child “Luxembourg”. International Journal of Otolaryngology and Head & Neck Surgery, 8, 139-149.
 Illé, S., James Didier, L., Saidou, A., Timi, N. and Sani, R. (2017) Résultats De 5ans De Thyroïdectomie Au Service D’orl Et Chirurgie Cervico-Faciale De l’Hôpital National De Niamey (Niger). European Scientific Journal, 13, 44-52.
 N’gouan, J.M., Téa, Z.B., et al. (2011) La chirurgie thyroidienne en ORL à Abidjan. Rev. Col. Odonto-Stomatol. Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale, 18, 45-49.
 Tabchouri, N., Anil, Z., et al. (2018) Morbidité de la thyroïdectomie totale pour goitre plongeant: série de 70 patients. Journal de Chirurgie Viscérale, 155, 10-15.
 Brenet, E., Dubernard, X., et al. (2017) évaluation et la prise en charge des goitres cervico-médiastinaux. Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale,134, 391-395.
 Vincent, G. (2008) Thyroidectomy over a Quarter of a Century in the Belgian Ardennes: A Retrospective Study of 1207 Patients. Acta Chirurgica Belgica, 108, 542-547.
 Périé, S., Aït-Mansour, A., et al. (2013) Intérêt du monitorage du nerf laryngé inférieur dans la stratégie opératoire au cours des thyroïdectomies et parathyroïdectomies totales. Annales françaises d’oto-rhino-laryngologie et de pathologie cervico-faciale, 130, 134-139.
 Khairy, G.A. and Al-Saif, A. (2011) Incidental Parathyroidectomy during Thyroid Resection: Incidence, Risk Factors, and Outcome. Annals of Saudi Medicine, 31, 274-278.
 Biet, A., Zaatar, R., Strunski, V. and Page, C. (2009) Complications postopératoires dans la thyroidectomie totale pour maladie de Basedow: Comparaison avec la chirurgie des goitres non basedowiens. Annales d’oto laryngologie et chirurgie cervico-faciale, 126, 190-195.