Background: Autonomic dysfunction in idiopathic Parkinson disease is a frequent and disabling complication, with an estimated prevalence of 47% and has a significant impact on the patient’s quality of life. Objectives: The main objective of this study was to determine the frequency of autonomic dysfunction among Sudanese Parkinson patients and identify possible risk factors attribute to develop autonomic dysfunction and to assess the extent to which the progression of dysautonomia affects activities of daily living, health-related quality of life. Methods: In this descriptive perspective, cross-sectional hospital-based study, 51 patients were studied using standardized questionnaire including history and clinical examination. Results: A total of 51 patients have been examined: male to female ratio 1.5:1; mean age 55 ± 5 years; Parkinson disease duration, 7 ± 2 years. 47% of the patients had one or more symptoms of autonomic dysfunction with mean age 59 ± 10. Constipation and bloating were the most common symptoms where sweating abnormality was the least symptoms to observe. The symptom of autonomic dysfunction has been worse with disease progression in 50% of the patients and 47% of the patients reported that both motors and autonomic dysfunction symptoms were causing disability than autonomic dysfunction symptoms alone. Conclusions: The study demonstrates that autonomic dysfunction is not only common in Parkinson Disease, but it increases in severity with increasing disease stages. Older age with long disease duration was also considered along with advanced disease stages strong factors determining the presence of autonomic dysfunction. The study recommends that symptoms of autonomic dysfunction survey be a routine aspect of the evaluation of Parkinson disease patients, especially with advanced age.
 Braak, H., Ghebremedhin, E., Rüb, U., Bratzke, H. and Del Tredici, K. (2004) Stages in the Development of Parkinson’s Disease-Related Pathology. Cell and Tissue Research, 318, 121-134.
 Morens, D.M., Grandinetti, A., Reed, D., White, L.R. and Ross, G.W. (1995) Cigarette Smoking and Protection from Parkinson’s Disease: False Association or Etiologic Clue? Neurology, 45, 1041-1051.
 Allcock, L.M. (2004) Frequency of Orthostatic Hypotension in a Community Based Cohort of Patients with Parkinson’s Disease. Journal of Neurology, Neurosurgery, and Psychiatry, 75, 1470-1471.
 Campos-Sousa, R.N., Quagliato, E., da Silva, B.B., de Carvalho, R.M., Ribeiro, S.C. and de Carvalho, D.F.M. (2003) Urinary Symptoms in Parkinson’s Disease: Prevalence and Associated Factors. Arquivos de Neuro-Psiquiatria, 61, 359-363.
 Okubadejo, N.U. and Danesi, M.A. (2004) Frequency and Predictors of Autonomic Dysfunction in Parkinson’s Disease: A Study of African Patients in Lagos, Nigeria. Nigerian Postgraduate Medical Journal, 11, 45-49.
 Wüllner, U., et al. (2007) Autonomic Dysfunction in 3414 Parkinson’s Disease Patients Enrolled in the German Network on Parkinson’s Disease (KNP e.V.): The Effect of Ageing. European Journal of Neurology, 14, 1405-1408.
 Khalid, K., Hussien, A., Khalafela, K., Yonis, A., Eltoum, A. and Hassan, A. (2009) Clinical Presentation of Parkinson’s Disease among Sudanese Patients. Sudan Journal of Medical Sciences, 4, 285-289.
 Kaufmann, H., Nahm, K., Purohit, D. and Wolfe, D. (2004) Autonomic Failure as the Initial Presentation of Parkinson Disease and Dementia with Lewy Bodies. Neurology, 63, 1093-1095.
 Edwards, L.L., Pfeiffer, R.F., Quigley, E.M.M., Hofman, R. and Balluff, M. (1991) Gastrointestinal Symptoms in Parkinson’s Disease. Movement Disorders, 6, 151-156.