Myasthenia is a chronic and disabling autoimmune disease which lesion is located between the nerve and the muscle, at the neuromuscular junction level  , affecting the somatic nervous system and therefore only the striated muscles  . It is a rare disease, according to current estimates in North America, the prevalence of serious myasthenia (SM) is about 19 to 21 per 100,000 populations  . In South Africa, the prevalence of SM was 10.42 cases per 100,000 people in 2010, increasing annually to reach 12.99 cases per 100,000 people in 2014. In Mali, there were 9 cases of serious myasthenia over 5 years from 2011 to 2016, of which the age range of 20 - 40 years represented 77.79% according to Sacko report  . We report a case of myasthenia in a 41-year-old patient in the Department of Internal Medicine at Point G University Teaching Hospital. No cases had been diagnosed in our department. The description of this case will allow us to list these rare pathologies to have a database.
A 41-year-old patient, Malian origin, trader, with a history of hémorroïdectomy in 2011 and familial hypertension, was admitted on August 19, 2014 for muscle weakness, dysphonia and dysphagia at the Department of Internal Medicine of the University Teaching Hospital of Point G. The disease started 1 year before admission to the department, marked by progressive installation of upper limbs muscle weakness aggravated by repetitive movements and spreading to the head “drooping head” and inferior limbs, associated with general fatigue, dysphonia and selective dysphagia for solid foods.
The persistence of these symptoms and the association with respiratory distress mainly asphyxia, the patient has performed several traditional medicines in bathing and orally without clinical improvement.
The patient weighed 62 kg for a height of 1.70 cm with a Body Mass Index of 21.45 kg/m2.
His temperature was 37.4˚C; his blood pressure was normal with 120/80 mm Hg. The respiratory rate was 19 cycles/min and the heart rate was 120 beats/min.
The consciousness was conserved with a Glasgow at 15/15. Upper limbs muscle strength rated at 4/5 and lower limb muscle strength rated 3/5. There was good tonicity. Ptosis and bilateral binocular diplopia were revealed by cranial pairs’ examination. The footstool sign was present.
The initial hemogram showed a hemoglobin normal level at 15.9 g/dl, hematocrit was normal at 45.9%, mean globular volume (MGV) was normal at 79.6 fl, normal serum creatinine level at 82 umol/l, normal blood glucose at 4.8 mmol/l, normal Transaminases (ALAT = 25, 9 IU/ L, AST/GOT = 23.2 IU/L)
The dosage of THSus was normal with 1.25 mU/L. Phosphokinase creatine (PKC) level was high with 1319 IU/L. The antibody anti-nuclear was negative with 0.62 EU. The C-reactive protein (CRP) was 68.1 mg/l. The dosage of the anti-acetylcholine receptor (RIA) antibody showed a high level at 47.50 nmol/l. The pharmacological test in neostigmine was positive. The post-synaptic neuromuscular conduction block (serious myasthenia) was found at Electroneuromyogram (ENMG). The chest CT scan performed was normal (Figure 1).
The tachycardia associated with the footstool sign was present. The hypothesis of hyperthyroidism was mentioned. The dosage of TSHus was normal.
The dermatopolymyositis was suspected based on the association of muscular weakness with dysphonia, dysphagia, ptosis and the footstool sign. The PKC was high; the dosage of the antinuclear antibody was negative. The Myogenic syndrome was not found at EMG. The muscle biopsy was not performed.
The diagnosis of myasthenia was retained based on the positive neostigmine therapeutic test, positive anti-acetylcholine receptor antibody (RIA) and the postsynaptic neuromuscular conduction block found at ENMG.
The patient received Neostigmine (prostagmine) at a dose of 0.5 mg 1 ampoule in IM/day and Prednisolone 20 mg at a dose of 1 mg/kg/day equivalent to 3 pills/day per os in decreasing dosage associated with adjuvant measures (chloride of potassium 600 mg, a capsule/day Calcium 1 g: 1 pill/day and Ivermectin 3 mg at the dosage of 200 μg/kg/day for two days, and Immunoglobulin in IV 2 g/kg in 2 days.
Figure 1. Chest CT scan: normal.
The evolution was marked by a moderate improvement of the symptomatology afterward the patient was evacuated in Tunisia at the request of the family where he received a course of immunoglobulin with 2 g/kg in 2 days. The evolution in Tunisia was favorable.
After return to Mali, death occurred 2 months later in a context of respiratory distress.
Myasthenia is an autoimmune pathology of the neuromuscular junction, clinically characterized by the installation of fluctuating muscle weakness with, in its classical form, symptoms limited to ptosis and diplopia  .
Its incidence varies from 1.7 - 10.4 per million per year to 21 per million in Barcelona. Its prevalence increases according to the latest statistics. It is observed at any age with two peaks:
− The first peak between 20 - 40 years old where women are more affected;
− The second peak after 50 years where men are the most affected  .
Its prevalence, unknown in France, is estimated in the literature from 100 to 200 per million  . Our patient was 41, age under 50 years which constitutes a particularity.
The reason for consulting of our patient was dysphonia and dysphagia. These signs are found in 5% of the cases whereas the muscular weakness was found in 10% of cases according to Grob et al.  . In another study, dysphagia was present in 37% of patients and dysphonia in 34% of patients. Signs as bilateral binocular diplopia were found in 79% s% of cases  and the ptosis in 5% of cases  .
The diagnosis of myasthenia in our patient was based on the positive neostigmine therapeutic test, which has a sensitivity of less than 100%  . The anti-acetylcholine receptor antibody was positive at 47.50 nmol/l for our patient. In one study, anti-acetylcholine receptor antibody was found in 94% of patients with asthenia and in 71% of patients with ocular myasthenia  and 80% to 90% of generalized myasthenia  . The postsynaptic neuromuscular conduction block was found at ENMG (electroneuromyogram), this neuromuscular block with electromyogram is greater than 80% for pure ocular forms and 95% for generalized forms  .
Our patient received Neostigmine (prostagmine) at a dose of 0.5 mg with 1 ampoule in IM/day causing regression of the symptomatology. In a recent study of 34 patients aged over 65 years, cholinesterase inhibitors (Neostigmine) only were sufficient for 41% of them  . In another study, the initial response to anticholinesterase treatment was fine (R, RP, AM) in 15 cases (54 p. 100) according to a comparative study of myasthenia in youth in two groups of subjects at different age all having myasthenia.
Prednisone 20 mg at a dosage of 1 mg/kg/day corresponding to 3 cp/day in a decreasing dose had led to an improvement in clinical signs. This effectiveness of corticotherapy was better in patients over 40 years old or having started their myasthenia after 40 years  .
In a series of 116 patients treated with 1 mg/ kg per day of prednisone, only 14% of patients were able to discontinue corticosteroids for their side effects (Pascuzzi et al., 1984).
The use of Immunoglobulin IV at a dose of 2 g/kg for two days had been effective. In the study conducted by Gajdos et al. (2005), the percentage of responders to IV Immunoglobulin was 50% to 60%  .
Improvement percentages of up to 75% have been reported for both therapies in several series analyzed retrospectively   .
Assessing evolution, our patient had an improvement both clinically and paraclinical marked by a decrease in muscle weakness, progressive disappearance of dysphonia and dysphagia.
Clinical evolution is marked by the transitory regression, more or less complete of signs according to Goulon-Goeau C  .
Autoimmune myasthenia is a rare disease with eye manifestations mostly inaugural directing the subject towards to the ophthalmologist. It is the first diagnosis to suspect in front of bilateral ptosis or not, fluctuating or not, and muscular weaknesses and dysphonia. Early diagnosis and neurological management would limit the risk of generalization of the disease that can compromise the vital prognosis. No treatment can definitely cure myasthenia.
Studies are needed to determine the possible particularities of the disease in sub-Saharan Africa given its scarcity.