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 IJMPCERO  Vol.8 No.3 , August 2019
A Comparative Study of Dosimetric Analysis of Three Different Sets of Five Fields and Seven Fields IMRT Plans for Prostate Cancer
Abstract:
The advent of Intensity Modulated Radiation Therapy (IMRT) is rapidly changing the field of Radiation Oncology. IMRT has the potential to improve clinical implementation of highly conformal non-convex dose distributions. Nonetheless, a number of IMRT approaches including coplanar and noncoplanar beam techniques with 5 to 9 beams at different angles have been used in an effort to get the best dose distribution. The purpose of this study is to compare the dose to normal tissue and dose-limiting structures, conformity index, homogeneity index, number of monitor units required for the treatment of prostate cancer in 3 sets of five and seven beam IMRT plans and thus to select the best IMRT approach for patients with prostate cancer.
Cite this paper: Zope, M. , Patil, D. , Kuriakose, A. , Rahman, A. , Trivedi, V. and Keshri, S. (2019) A Comparative Study of Dosimetric Analysis of Three Different Sets of Five Fields and Seven Fields IMRT Plans for Prostate Cancer. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 8, 175-192. doi: 10.4236/ijmpcero.2019.83016.
References

[1]   Hanks, G.E., Hanlon, A.L., Epstein, B., et al. (2002) Dose Response in Prostate Cancer with 8-12 Years’ Follow-Up. International Journal of Radiation Oncology, Biology, Physics, 54, 427-435.
https://doi.org/10.1016/S0360-3016(02)02954-1

[2]   Dearnaley, D.P., Sydes, M.R., Graham, J.D., et al. (2007) Escalated-Dose versus Standard-Dose Conformal Radiotherapy in Prostate Cancer: First Results from the MRC RT01 Randomised Controlled Trial. The Lancet Oncology, 8, 475-487.
https://doi.org/10.1016/S1470-2045(07)70143-2

[3]   Peeters, S.T., Heemsbergen, W.D., Koper, P.C., et al. (2006) Dose-Response in Radiotherapy for Localized Prostate Cancer: Results of the Dutch Multicenter Randomized Phase III Trial Comparing 68 Gy of Radiotherapy with 78 Gy. Journal of Clinical Oncology, 24, 1990-1996.
https://doi.org/10.1200/JCO.2005.05.2530

[4]   Zelefsky, M.J., Chan, H., Hunt, M., et al. (2006) Long-Term Outcome of High Dose Intensity Modulated Radiation Therapy for Patient with Clinically Localized Prostate Cancer. Journal of Urology, 176, 1415-1419. https://doi.org/10.1016/j.juro.2006.06.002

[5]   Shu, H.K., Lee, T.T., Vigneauly, E., et al. (2001) Toxicity Following High-Dose Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy for Clinically Localized Prostate Cancer. Urology, 57, 102-107. https://doi.org/10.1016/S0090-4295(00)00890-6

[6]   Stein, J., Mohan, R., Wang, X.H., et al. (1997) Number and Orientations of Beams in Intensity-Modulated Radiation Treatments. Medical Physics, 24, 149-160.
https://doi.org/10.1118/1.597923

[7]   Schreibmann, E. and Xing, L. (2004) Feasibility Study of Beam Orientation Class-Solutions for Prostate IMRT. Medical Physics, 31, 2863-2870. https://doi.org/10.1118/1.1797571

[8]   Semerenko, V.A., Reitz, B., Day, E., Qi, X.S., Miften, M. and Li, X.A. (2008) Evaluation of a Commercial Biologically Based IMRT Treatment Planning System. Medical Physics, 35, 5851-5860. https://doi.org/10.1118/1.3013556

[9]   Shaw, E., Kline, R., Gillin, M., Souhami, L., Hirschfeld, A., Dinapoli, R., et al. (1993) Radiation Therapy Oncology Group: Radiosurgery Quality Assurance Guidelines. International Journal of Radiation Oncology, Biology, Physics, 27, 1231-1239.
https://doi.org/10.1016/0360-3016(93)90548-A

[10]   Bray, F., et al. (2018) Global Cancer Statistics 2018: GLOBOCON Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: A Cancer Journal for Clinicians, 68, 394-424. https://doi.org/10.3322/caac.21492

[11]   Al-Mamgani, A., van Putten, W.L., Heemsbergem, W.D., et al. (2008) Update of Dutch Multicentre Dose-Escalation Trial of Radiotherapy for Localized Prostate Cancer. International Journal of Radiation Oncology, Biology, Physics, 72, 980-988.
https://doi.org/10.1016/j.ijrobp.2008.02.073

[12]   Michalski, J.M., Yan, Y., Watkins-Bruner, D., et al. (2013) Preliminary Toxicity Analysis of 3DCRT versus IMRT on the High Dose Arm of the RTOG 0126 Prostate Cancer Trial. International Journal of Radiation Oncology, Biology, Physics, 87, 932-938.
https://doi.org/10.1016/j.ijrobp.2011.06.004

[13]   Zelefsy, M.J., Cowen, D., Fuks, Z., et al. (1999) Long Term Tolerance of High Dose Three-Dimensional Conformal Radiotherapy in Patients with Localized Prostate Cancer. Cancer, 85, 2460-2468.
https://doi.org/10.1002/(SICI)1097-0142(19990601)85:11<2460::AID-CNCR23>3.0.CO;2-N

[14]   Hall, E.J. and Wu, C.S. (2003) Radiation-Induced Second Cancers: The Impact of 3D-CRT and IMRT. International Journal of Radiation Oncology, Biology, Physics, 56, 83-88.
https://doi.org/10.1016/S0360-3016(03)00073-7

[15]   Potrebko, P.S., McCurdy, B.M., Butler, J.B., et al. (2007) Optimal Starting Gantry Angles Using Equiangular-Spaced Beams with Intensity Modulated Radiation Therapy for Prostate Cancer on RTOG 0126: A Clinical Study of 5 and 7 Fields. Radiotherapy and Oncology, 85, 299-305.
https://doi.org/10.1016/j.radonc.2007.06.019

[16]   Mahdavi, S., JazayeriGharehbagh, E., Nikoofar, A., et al. (2017) Radiation Treatment Planning for Prostate Cancer: A New Dosimetric Comparison of Five and Seven Fields IMRT Plans. International Journal of Radiation Research, 15, 177-183.
https://doi.org/10.18869/acadpub.ijrr.15.2.177

 
 
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