IJMPCERO  Vol.8 No.3 , August 2019
Comparative Study of Dose Distribution Homogeneity between 3D-Brachytherapy and Intensity Modulated Radiation Therapy Techniques in Cervix Cancer Tumors
Aim: The purpose of this study was to compare the dosimetric results of the techniques (3D-Brachytherapy and intensity-modulated radiotherapy IMRT) in patients with locally advanced cervical carcinoma (LACC). Method: There are 15 patients with locally advanced cervical carcinoma (LACC), after the completion of external beam radiotherapy (EBRT) for the whole pelvic irradiation 45 Gy/25 fractions, followed by 3D-Brachytherapy 24 Gy per weekly fractions and 36 Gy of IMRT per 18 fractions. Coverage of targets volume and doses received by normal tissue were compared in two techniques. Method: 15 patients of LACC treated with 3D-Brachytherapy were selected for this study. IMRT plans were also created for all the patients. 3D-Brachytherapy and IMRT plans were compared on the basis of target volume coverage, dose to Organs at risk (OAR’s), homogeneity index (HI) and conformity index (CI). Results: The results showed that D90% of HRCTV in the 3D-Brachytherapy was covered more than D90% of PTV in the IMRT of prescribed dose, the D2CC and the V60Gy values of Bladder and rectum were significantly lower than in 3D-Brachytherapy. The HI and CI in 3D-Brachytherapy were found better than IMRT. Conclusion: 3D-Brachytherapy significantly reduced the irradiated volume of OAR’s and improved dose coverage in tumor volume compared to that by IMRT.
Cite this paper: Elnagger, M. , Motaweh, H. and Zard, K. (2019) Comparative Study of Dose Distribution Homogeneity between 3D-Brachytherapy and Intensity Modulated Radiation Therapy Techniques in Cervix Cancer Tumors. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 8, 163-174. doi: 10.4236/ijmpcero.2019.83015.

[1]   World Health Organization (2018) Cancer, Cancer Prevention, Early Diagnosis and Screening.

[2]   De la Garza-Salazar, J.G., Morales-Vásquez, F. and Meneses-Garcia, A. (2017) Cervical Cancer. Springer, Berlin, Chapter 1.

[3]   Price, P. and Sikora, K. (2012) An Introduction to Different Types of Radiotherapy. Treatment of Cancer, 5th Edition. NCRI Clinical and Translational Radiotherapy Research Working Group (CTRad).

[4]   Montemaggi, P., Trombetta, M. and Brady, L.W. (2016) Brachytherapy: An International Perspective. Springer, Berlin, 1-29.

[5]   Kollmeier, M.A., McBride, S., Taggar, A., Anderson, E., Lin, M., Pei, X. and Zelefsky, M.J. (2017) Salvage Brachytherapy for Recurrent Prostate Cancer after Definitive Radiation Therapy: A Comparison of Low-Dose-Rate and High-Dose-Rate Brachytherapy and the Importance of Prostate-Specific Antigen Doubling Time. Brachytherapy, 16, 1091-1098.

[6]   Hoskin, P. (2012) External Beam Therapy. 2nd Edition, Oxford University Press, Oxford, 1, 3-25.

[7]   Khan, F.M. and Gibbons, J.P. (2014) Khan’s the Physics of Radiation Therapy. 5th Edition, Lippincott Williams and Wilkins, Philadelphia, Part 3, 19-430.

[8]   Petrova, D., Smickovska, S. and Lazarevska, E. (2017) Conformity Index and Homogeneity Index of the Postoperative Whole Breast Radiotherapy. Open Access Macedonian Journal of Medical Sciences, 5, 736-739.

[9]   Yin, G., Wang, P., Lang, J., Tian, Y., Luo, Y., Fan, Z. and Tam, K.Y. (2016) Dosimetric Study for Cervix Carcinoma Treatment Using Intensity Modulated Radiation Therapy (IMRT) Compensation Based on 3D Intracavitary Brachytherapy Technique. Journal of Contemporary Brachytherapy, 3, 221-232.

[10]   Voyant, C., Julian, D., Roustit, R., Biffi, K. and Lantieri, C. (2014) Biological Effects and Equivalent Doses in Radiotherapy: A Software Solution. Reports of Practical Oncology & Radiotherapy, 19, 47-55.

[11]   Naik, A., Gurjar, O., Bagdare, P., Gupta, K., Bhandari, V. and Kausar, M. (2016) Dosimetric Comparison between Intensity Modulated Radiotherapy and Three Dimensional Conformal Radiotherapy Planning in Patients with Locally Advanced Cervical Carcinoma. International Journal of Radiation Research, 14, 189-196.

[12]   Jeraj, M. and Robar, V. (2004) Multileaf Collimator in Radiotherapy. Radiology and Oncology, 38, 235-240.

[13]   Chadha, M., Guo, G., Kolev, V., Kalach, N., Bernstein, K., Cohen, S. and Koulos, J. (2016) Experience Using 3 Fractions of 8 Gy High-Dose-Rate Brachytherapy Once a Week Following Chemoradiation Therapy in Clinical Node-Negative Cervix Cancer. International Journal of Radiation Oncology Biology Physics, 96, E294-E295.

[14]   Shwetha, B., Ravikumar, M., Palled, S.R., Supe, S.S. and Sathiyan, S. (2011) Dosimetric Comparison of High Dose Rate Brachytherapy and Intensity-Modulated Radiation Therapy for Cervical Carcinoma. Journal of Medical Physics, 36, 111-116.

[15]   Hanania, A.N., Yoder, A., Myers, P., Yu, Z.H., Bulut, A., Eraj, S., Ludwig, M., et al. (2018) A Single Institution Experience of Image-Guided High-Dose Rate Interstitial Brachytherapy in the Definitive Setting for Locally Advanced Cervical Cancer. Brachytherapy, 17, S123-S124.