JBM  Vol.7 No.5 , May 2019
MOFzyme: Enzyme Mimics of Fe/Fe-MIL-101
In this work, metal-organic frameworks (MOFs) Fe-MIL-101 was synthesized by hydrothermal method, and Fe/Fe-MIL-101 with different loadings was prepared. The crystal structure of the Fe/Fe-MIL-101 sample was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and specific surface area measurement (BET). Fe/Fe-MIL-101 was found to posses an intrinsic enzyme mimicking activity similar to that found in natural horse-radish peroxidase (HRP). The Michaelis constant (Km) of 5% Fe/Fe-MIL-101 with ABTS as the substrate is about 10-fold smaller than Fe-MIL-101 and about 3-fold smaller than HRP, and about 108 times less than that of CuO NPs (Km = 10.28 mM), indicating a much higher affinity for ABTS than HRP and most of the peroxidase mimetics.
Cite this paper: Li, L. , Chen, D. , Li, B. , Yang, D. , Zhao, J. , Ma, D. , Jiang, L. , Yang, Y. , Li, Y. , Wang, J. (2019) MOFzyme: Enzyme Mimics of Fe/Fe-MIL-101. Journal of Biosciences and Medicines, 7, 213-221. doi: 10.4236/jbm.2019.75023.

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