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 MSA  Vol.10 No.5 , May 2019
How Polydopamine Modulates Biological Responses to PTFE Prostheses
Abstract: Diaphragm repair after congenital diaphragmatic hernia is associated with hernia recurrence due to prosthesis failure. Expanded polytetrafluoroethylene (e-PTFE), a synthetic non-degradable biomaterial, is currently used for those diaphragmatic defect repairs. The drawback of e-PTFE is its poor wettability that leads to coating difficulties, bonding that could favor implant integration. However, polydopamine (PDA) can be deposited as well on organic as on inorganic substrates. Therefore, we assessed the biological responses of a clinically used e-PTFE biomaterial treated with PDA in two different manners: one impregnated with PDA and the other coated with a one side PDA film. Mechanical properties of the raw e-PTFE, the PDA soaked biomaterial and the PDA coated surface were characterized by colloidal probe atomic force microscopy. Behaviors of primary human fibroblasts and Wharton’s jelly stem cells were investigated by electron microscopy. Findings reveal that the mechanical properties at the microscopic scale are not modified by the PDA treatments. Cells spread onto both PDA functionalized substrates. In addition, microscopic observations disclose numerous focal cell contacts, evidencing cell attachment, and cytoplasmic projections particularly with the nanoscale PDA coating. Results clearly suggest that PDA in general but above all the PDA coating enhance cellular colonization of the implant material.
Cite this paper: Talon, I. , Schneider, A. , Mathieu, E. , Senger, B. , Frisch, B. , Seguin, C. , Ball, V. and Hemmerlé, J. (2019) How Polydopamine Modulates Biological Responses to PTFE Prostheses. Materials Sciences and Applications, 10, 377-392. doi: 10.4236/msa.2019.105028.
References

[1]   Congenital Diaphragmatic Hernia Study Group (2007) Defect Size Determines Survival in Infants with Congenital Diaphragmatic Hernia. Pediatrics, 120, e651-e657.
https://doi.org/10.1542/peds.2006-3040

[2]   Discher, D.E., Janmey, P. and Wang, Y.L. (2005) Tissue Cells Feel and Respond to the Stiffness of Their Substrate. Science, 310, 1139-1143.
https://doi.org/10.1126/science.1116995

[3]   Orr, A.W., Helmke, B.P., Blackmann, B.R. and Schwartz, M.A. (2006) Mechanisms of Mechanotransduction. Developmental Cell, 10, 11-20.
https://doi.org/10.1016/j.devcel.2005.12.006

[4]   Kalaba, S., Gerhard, E., Winder, J.S., Pauli, E.M., Haluck, R.S. and Yang, J. (2016) Design Strategies and Applications of Biomaterials and Devices for Hernia Repair. Bioactive Materials, 1, 2-17.
https://doi.org/10.1016/j.bioactmat.2016.05.002

[5]   Ratner, B.D. (2004) Surface Properties and Surface Characterization of Materials. In: Ratner, B.D., Hoffman, A.S. and Schoen, F.J., Eds., Biomaterials Science: An Introduction to Materials in Medicine, 2nd Edition, Elsevier Academic Press, London, 40-59.

[6]   Matthews, B.D., Pratt, B.L., Pollinger, H.S., Backus, C.L., Kercher, K.W., Sing, R.F. and Heniford, B.T. (2003) Assessment of Adhesion Formation to Intra-Abdominal Polypropylene Mesh and Polytetrafluoroethylene Mesh. Journal of Surgical Research, 114, 126-132.
https://doi.org/10.1016/S0022-4804(03)00158-6

[7]   Liu, Y., Ai, K. and Lu, L. (2014) Polydopamine and Its Derivative Materials: Synthesis and Promising Applications in Energy, Environmental, and Biomedical Fields. Chemical Reviews, 114, 5057-5115.
https://doi.org/10.1021/cr400407a

[8]   Ponzio, F., Payamyar, P., Schneider, A., Winterhalter, M., Bour, J., Addiego, F., Krafft, M.P., Hemmerle, J. and Ball, V. (2014) Polydopamine Films from the Forgotten Air/Water Interface. The Journal of Physical Chemistry Letters, 5, 3436-3440.
https://doi.org/10.1021/jz501842r

[9]   Butt, H.J. and Jaschke, M. (1995) Calculation of Thermal Noise in Atomic Force Microscopy. Nanotechnology, 6, 1-7.
https://doi.org/10.1088/0957-4484/6/1/001

[10]   Hertz, H. (1881) über die Berührung fester elastischer Korper. Journal für die reine und angewandte Mathematik, 92, 156-171.

[11]   Kharraz, Y., Guerra, J., Mann, C.J., Serrano, A.L. and Munoz-Cánoves, P. (2013) Macrophage Plasticity and the Role of Inflammation in Skeletal Muscle Repair. Mediators of Inflammation, 2013, Article ID: 491497.
https://doi.org/10.1155/2013/491497

[12]   Fisher, J.C., Haley, M.J., Ruiz-Elizalde, A., Stolar, C.J. and Arkovitz, M.S. (2009) Multivariate Model for Predicting Recurrence in Congenital Diaphragmatic Hernia. Journal of Pediatric Surgery, 44, 1173-1179.
https://doi.org/10.1016/j.jpedsurg.2009.02.043

[13]   Fauza, D.O. (2014) Tissue Engineering in Congenital Diaphragmatic Hernia. Seminars in Pediatric Surgery, 23, 135-140.
https://doi.org/10.1053/j.sempedsurg.2014.04.004

[14]   Clowes, A.W., Kirkman, T.R. and Reidy, M.A. (1986) Mechanisms of Arterial Graft Healing: Rapid Transmural Capillary Ingrowth Provides a Source of Intimal Endothelium and Smooth Muscle in Porous PTFE Prostheses. The American Journal of Pathology, 123, 220-230.

[15]   Gabriel, M., Niederer, K., Becker, M., Raynaud, C.M., Vahl, C.F. and Frey, H. (2016) Tailoring Novel PTFE Surface Properties: Promoting Cell Adhesion and Antifouling Properties via a Wet Chemical Approach. Bioconjugate Chemistry, 27, 1216-1221.
https://doi.org/10.1021/acs.bioconjchem.6b00047

[16]   Yang, H.C., Waldman, R.Z., Wu, M.B., Hou, J., Chen, L., Darling, S.B. and Xu Z.K. (2018) Dopamine: Just the Right Medicine for Membranes. Advanced Functional Materials, 28, Article ID: 1705327.
https://doi.org/10.1002/adfm.201705327

[17]   Yang, H.C., Luo, J.Q., Lv, Y., Shen, P. and Xu, Z.K. (2015) Surface Engineering of Polymer Membranes via Mussel-Inspired Chemistry. Journal of Membrane Science, 483, 42-59.
https://doi.org/10.1016/j.memsci.2015.02.027

[18]   Jiang, Z., Jiang, L., Jia, H., Zhou, Y., Ma, J. and Chen, S. (2018) Modification of Polytetrafluoroethylene-Fiberglass Composite Film Using Polydopamine Deposition with Improved Hydrophilicity. Fibers and Polymers, 19, 1760-1766.
https://doi.org/10.1007/s12221-018-8114-2

[19]   Engler, A.J., Sen, S., Sweeney, H.L. and Discher, D.E. (2006) Matrix Elasticity Directs Stem Cell Lineage Specification. Cell, 126, 677-689.
https://doi.org/10.1016/j.cell.2006.06.044

[20]   Breuls, R.G., Jiya, T.U. and Smit, T.H. (2008) Scaffold Stiffness Influences Cell Behavior: Opportunities for Skeletal Tissue Engineering. The Open Orthopaedics Journal, 2, 103-109.
https://doi.org/10.2174/1874325000802010103

[21]   Schneider, A., Talon, I., Mathieu, E., Schaaf, P., Becmeur, F. and Hemmerlé, J. (2017) New Insight in the Biological Integration of Polytetrafluoroethylene from an Explant Used for Diaphragm Repair. Journal of Biomaterials Applications, 31, 844-850.
https://doi.org/10.1177/0885328216676757

[22]   Mellander, S., Fogelstrand, P., Enocson, K., Johansson, B.R. and Mattsson, E. (2005) Healing of PTFE Grafts in a Pig Model Recruit Neointimal Cells from Different Sources and Do Not Endothelialize. European Journal of Vascular and Endovascular Surgery, 30, 63-70.
https://doi.org/10.1016/j.ejvs.2005.02.051

[23]   Bax, D.V., Wang, Y., Li, Z., Maitz, P.K., McKenzie, D.R., Bilek, M.M. and Weiss, A.S. (2011) Binding of the Cell Adhesive Protein Tropoelastin to the PTFE through Plasma Immersion Ion Implantation Treatment. Biomaterials, 32, 5100-5111.
https://doi.org/10.1016/j.biomaterials.2011.03.079

 
 
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