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 SS  Vol.2 No.10 , December 2011
Elevation of Serum CA-125 in Mucinous Cystadenoma of the Ovary with Torsion: A Rare Occurrence and Review of the Literature
Abstract: Aim: Benign neoplasms of the ovary originating from epithelial tissue are common tumors in adult women. They are, however, rarely seen in children or adolescent girls with elevation of serum carbohydrate antigen- 125 (CA-125). The present report describes a rare case of premenarchal women with a giant mucinous cystadenoma (MCA) of the ovary with torsion complicated with elevation of serum CA-125. Case: A 15-year-old, premenarchal, previously healthy girl was referred to our hospital with a 2-week history of left lower abdominal pain. Physical examinations showed a firm and mobile mass with tenderness in the left lower quadrant. Tumor markers showed CA-125 at 124.1 U/ml. An enhanced computed tomography scan showed a multiloculated tumor that was partly solid, compressing the small intestine, uterus, and urinary bladder, but no signs of organ invasion, lymph node swelling, or ascitis. Via a lower transverse incision, the right Fallopian tube was observed to have twisted 1620。 counterclockwise, and a tense cyst measuring 22.0 × 12.0 × 10.5 cm and weighing 1.78 kg was found in the right ovary. Release from torsion and unilateral salpingo-oophorectomy with tumor removal was performed because blood flow to the right Fallopian tube did not improve after torsion release. The histopathological findings showed an MCA of the ovary without cell dysplasia. The patient did not receive adjuvant chemotherapy following surgery. There was no evidence of recurrence at 2 years. Disucussion: We need to consider MCA of the ovary when there is elevation of the serum CA-125 and an ovarian mass.
Cite this paper: nullT. Okada, S. Honda, H. Miyagi, M. Minato, K. Kubota and A. Taketomi, "Elevation of Serum CA-125 in Mucinous Cystadenoma of the Ovary with Torsion: A Rare Occurrence and Review of the Literature," Surgical Science, Vol. 2 No. 10, 2011, pp. 499-501. doi: 10.4236/ss.2011.210110.
References

[1]   T. S. Paran, A. Mortell, D. Devaney, A. Pinter and P. Puri, “Mucinous Cystadenoma of the Ovary in Perimenarchal Girls,” Pediatric Surgery International, Vol. 22, No. 3, 2006, pp. 224-227. doi:10.1007/s00383-005-1624-1

[2]   W. R. Hart, “Mucinous Tumors of the Ovary: A Review,” International Journal of Gynecology and Pathology, Vol. 24, No. 1, 2005, pp. 24-25.

[3]   J. L. Breen and W. S. Maxson, “Ovarian Tumors in Children and Adolescents,” Clinical Obstetrics and Gynecology, Vol. 20, No. 3, 1977, pp. 607-623. doi:10.1097/00003081-197709000-00010

[4]   B. Baksu, A. Akyol, I. Davas, A. Yazqan, J. Ozqul and C. Tanik, “Recurrent Mucinous Cystadenoma in a 20-Year-old Woman was Hystectomy Inevitable?” Journal of Obstetrics and Gynaecology Research, Vol. 32, No. 6, 2006, pp. 615-618. doi:10.1111/j.1447-0756.2006.00453.x

[5]   C. Flotho, K. Rückauer, U. Duffner, E. Berqstasser, N. Bohm and C. M. Niemeyer, “ Mucinous Cystadenoma of the Ovary in a 15-Year-Old Girl,” Journal of Pediatric Surgery, Vol. 36, No. 6, 2001, p. E6. doi:10.1053/jpsu.2001.24019

[6]   J. Deprest, P. Moerman, P. Corneillie, P. Ide, “Ovarian Borderline Mucinous Tumor in a Premenarchal Girl: Review on Ovarian Epithelia Cancer in Young Gilrs, Gynecologic Oncolology, Vol. 45, No. 2, 1992, pp. 219-224.

[7]   E. E. Lack, R. H. Young, R. E. Scully, “Pathology of Ovarian Neoplasms in Childhood and Adolescence,” Pathology Annual, Vol. 27, 1992, pp. 281-356.

[8]   M. Mandai, I. Konishi, H. Kuroda, T. Komatsu, S. Yamamoto, K. Nanbu, K. Matsushita, M. Fukumoto, H. Yamabe and T. Mori, “Heterogenous Distribution of K-rasmutated Epithelia in Mucinous Ovarian Tumors with Special Reference to Histopathology,” Humman Pathology, Vol. 28, No. 1, 1998, pp. 34-40. doi:10.1016/S0046-8177(98)90387-2

[9]   C. J. Link Jr., E. Reed, G. Sarosy and E. C. Kohn, “Borderline Ovarian Tumors,” American Journal of Medicine, Vol. 101, No. 2, 1996, 217-225. doi:10.1016/S0002-9343(96)80079-9

[10]   P. W. Cronen and H. S. Nagaraj, “Ovarian Tumors in Children,” Southern Medical Journal, Vol. 81, No. 4, 1988, 464-468. doi:10.1097/00007611-198804000-00014

 
 
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