ABSTRACT In the last two decades, 5-fluorouracil (5-FU) is widely used in clinical practice to inhibit the fibroblasts to proliferate and improve the success rate of glaucoma-filtering surgery, but 5-FU has many toxic effects to normal ocular tissues. The self-assembled peptide hydrogels may serve as a new class of biomaterials for applications including tissue engineering and drug delivery. How to deliver 5-FU quickly and precisely to the target sites of ocular tissue by a self-assembled peptide hydrogel remains unexplored. RGD (arginine-glycine-aspartic acid) sequence is cell attachment site in extracellular matrix (ECM). Thus, If the self-assembled peptide hydrogel containing the RGD sequence that act as a specific attachment site for the proliferated fibroblasts adhesion could be designed, after integrated 5-FU, a novel targeting drug delivery system will be put into practice in the future.
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nullLiang, L. , Yang, J. , Li, Q. , Huo, M. , Jiang, F. , Xu, X. and Zhang, X. (2011) A Novel Targeting Drug Delivery System Based on Self-Assembled Peptide Hydrogel. Journal of Biomaterials and Nanobiotechnology, 2, 622-625. doi: 10.4236/jbnb.2011.225074.
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