Coffee is the most consumed beverage in the world. Caffeine has been used as a drug for thousands of years. There are several plants that contain the substance that was grown or harvested, but today caffeine is added to many foods. Despite the increased use of caffeine in recent times, many people have little knowledge of the general effects it has on their bodies.
Caffeine, a xanthine alkaloid, was first identified in coffee. Therefore, it is the active ingredient in coffee, but it can be present in many foods and beverages. This substance belongs to the group of compounds of methylxanthines, which also includes tea. Xanthines are substances capable of stimulating the nervous system, producing a certain alertness of short duration.
In addition to coffee, caffeine is also found in other drinks, in smaller proportions, such as those containing cocoa, cola and chocolate; in addition to tea and some analgesic or cold remedies. Due to the diversity of products containing caffeine, it is, without a doubt, the most popular psychoactive drug in the world.
Considering that caffeine is present in coffee, tea, chocolates, caffeine-based soft drinks or medicines, it can be said that in general the population makes use of this substance daily, although it is very difficult to quantify its consumption.
2. Materials and Methods
This is a systematic review of the literature, in order to search for articles in the literature, to analyze and identify the main effects of caffeine on the body.
Galvão and Pereira (2014)  understand that systematic reviews differ from narrative or traditional revisions. These are broad and provide general information on the subject in question. They are also distinguished from integrative reviews, in which different designs are used in the same research, in addition to expressing the author’s own opinion. Systematic reviews are considered secondary studies, which have in their primary studies their data source.
According to Muñoz (2002)  , the systematic review is a method that has been increasingly used in scientific research for the evaluation of a data set simultaneously, given the ability to integrate the findings of existing individual research, allowing, in an objective way, the synthesis of scientific information.
In order to select the studies, an online survey of articles published in the Scientific Electronic Library Online (SciELO), Medical Literature Analysis and Retrieval System Online (MEDLINE) and Latin American and Caribbean Literature in Health Sciences (LILACS), using the descriptors “caffeine”, “effects of caffeine” and “methylxanthine”. We included the studies published between the years 2000 to 2018, which explicitly contemplate the evaluated aspects.
The descriptors used allowed the collection of scientific articles used in the review. After the search with the descriptors in the databases, a total of 28 articles were found in the Portuguese language. However, from this total, animal studies and studies that did not refer to the central nervous system, effects on the organism, performance, memory, blood pressure and ergogenic potential were excluded. Through this process, the final sample consisted of eight articles, as shown in Table 1.
Table 1. Identification of articles.
3. Results and Discussion
The evaluation of the articles consisted in reading the study in its entirety through the technique of content analysis and the following important points were defined: 1) caffeine; 2) Caffeine actions on the body and 3) side effects with excess caffeine intake.
Caffeine is the drug of greatest employment, the highest social acceptance and most widely used in the world. In its natural sources, caffeine has been consumed by man throughout the world for centuries. It is consumed regularly by billions of people, configuring diverse and varied cultural practices, and is even vital for some economies.
Caffeine, chemically known as 1,3,7-trimethylxanthine, is the active ingredient in coffee, but it can be present in many foods and beverages. This substance belongs to the group of compounds of methylxanthines, which also includes tea. Xanthines are substances capable of stimulating the nervous system, producing a certain alertness of short duration. Today caffeine is regularly consumed by billions of people around the world, configuring diverse and varied cultural practices, and is even vital for some economies  .
According to Roberts HR, Barone JJ (1983, apud Carvalho et al., 2006)  , since its chemical isolation in 1820, caffeine has been found to be a stimulant in a variety of medicines used as analgesics, diuretics, weight allergy-relieving preparations.
3.2. Caffeine Actions on the Body
Caffeine has a significant participation in the mechanism involving the actions of the central and peripheral system, resulting in changes in the metabolic and physiological processes.
According to Revista TodaBiologia.com. (2018)  , in the article entitled “Caffeine and its effects on health”, stresses that:
Researchers at the Harvard School of Public Health have released studies in July 2013 that show that caffeine not only stimulates the central nervous system but can also act as a mild antidepressant, boosting the production of certain neurotransmitters (serotonin, noradrenaline) in the brain. The researchers also concluded that the suicide risk for adults who ate 2 to 4 cups of coffee per day was 50 percent lower than those who drank decaffeinated coffee or too little or no coffee (source: Harvard Gazette, July 2013).
In view of this, we can affirm that caffeine affects normal cellular function and has several physiological effects. It is a Central Nervous System (CNS) stimulant and, depending in part on the amount consumed, can produce a variety of effects on other organs.
According to Carvalho et al. (2006)  , in his researches, emphasizes that:
in the central nervous system, more precisely in the autonomic nervous system, the neurotransmitter system based on the neurotransmitter adenosine acts as a reducer of heart rate, blood pressure and body temperature. Caffeine exerts an inhibitory action on neurotransmitter adenosine receptors, located in nerve cells. Many of the physiological responses to caffeine administration are opposite to those of adenosine, so there is a feeling of re-energizing, decreased sleep, and fatigue. Caffeine has an effect on the release of nerve cells and the release of some other neurotransmitters and hormones, such as adrenaline.
The effects of caffeine on the body are numerous, so it is a stimulation of the central nervous system that increases organic activity and streamlines mental and bodily and mental functions.
In relation to intellectual performance, coffee consumption increases short-term memory, facilitates the memorization process because it improves concentration, helps maintain mental acuity and reduces cognitive deterioration in the elderly  .
According to Cavalcante (2000)  , studies have shown that methylxanthines, such as caffeine, are competitive antagonists of A1 and A2 adenosine receptors found in the brain, heart, lungs, peripheral vessels and platelets. The effects of caffeine on blood pressure are controversial. Some research suggests that its action on peripheral vascular resistance is less intense than its effect on the central nervous system, the latter being primarily responsible for the increase in peripheral vascular resistance.
On the other hand, caffeine is a substance that has been used by sportspeople for the purpose of improving physical performance. Its ergogenic potential has been tested in physical exercises of different natures. It is believed that caffeine has central and peripheral mechanisms of action that can excite or restore cerebral and bulbar functions, as well as trigger important metabolic and physiological changes that would improve athletic performance. Despite the lack of consensus among researchers on the effectiveness of caffeine use for optimizing physical performance, numerous athletes have used this substance, however, without the necessary care, which can contribute to the appearance of undesirable side effects, putting in risk, mainly, the physical integrity of these individuals  .
According to the authors cited, caffeine can provide an increase in muscle strength accompanied by a greater resistance to the installation of the process of muscle fatigue. It is still not fully understood which mechanism of action responsible for the increase in muscle strength, however, it is believed that this occurs more strongly by the direct action of caffeine in the Central Nervous System than by its action at the peripheral level.
The possibility of improving physical performance has led to this alkaloid being placed on the list of substances banned by the International Olympic Committee (IOC), which set the limit of 12 μg/mL caffeine in urine as a parameter for doping detection. Some studies have shown that these levels can be achieved with the intake of approximately 9 mg of caffeine per kilogram of body weight. However, recent statistics have shown improvement in athletic performance with intake of only 3 to 6 mg of caffeine per kilogram of body weight  .
3.3. Side Effects of Caffeine Intake
According to Altimari et al. (2005)  , the effect of caffeine varies from person to person, taking into account its weight and its regularity in intake. It is believed that the habituation of this substance is possible from the chronic intake of 100 mg/day of caffeine which is equivalent to approximately one and a half cups of 150 ml instant coffee, three and a half cups of 150 ml instant tea, three bars of 160 g of milk chocolate, two cans of 350 ml of glue-based soft drink or one can and half of Red BullÒ energy drink. With this dosage, the expected effects are neutralized, but if habitual users, stay four days without ingesting the caffeine, they lose that adaptation.
According to Almeida, Pereira and Moreira (2013)  , several studies have shown that it is a fact that caffeine alters some of the factors that influence cardiovascular health, such as plasma homocysteine levels, serum cholesterol levels, heart rate in addition to blood pressure. However, the magnitude of these changes, against a risk of cardiovascular death, still proves to be minimal, preventing us from gauging any judgment that caffeine may be a beneficial substance or not.
The authors mentioned above emphasize that in relation to the changes in cardiac electrical conduction, the researches developed so far and several reports of cases present in the literature show varying results, sometimes even contradictory results. With this, the medical class still does not have sufficient evidence to indicate a change in the habits of use of the caffeine.
The objective of this study was to identify the main effects of caffeine on the body, a substance found in various food products like coffee and chocolate, consumed worldwide and used by athletes as food supplement as well.
According to the literature, it can be confirmed that caffeine directly interferes with the central nervous system.
It can be affirmed that the moderate consumption of coffee does not represent a risk to health, presenting a protective effect in several pathologies. The proven benefits of coffee justify its inclusion in the functional foods group, not only for caffeine but also for other compounds present in coffee.
Current evidence has shown moderate consumption of caffeine is a therapeutic resource as it promotes physical and mental performance. However, further studies, with an emphasis on neurobiology, will be needed to elucidate the potential abusive effect on caffeine use, its risks and benefits.
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