JBNB  Vol.2 No.5 , December 2011
Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs
ABSTRACT
Nanocluster polyoxometalates with a structure of buckyball (fullerene) are a promising means of targeted delivery of drugs in the body. In this paper, based on an analysis of histological sections of liver and kidney and peripheral blood, showed a significant reduction of toxicity of buckyballs, containing ions of molybdenum (VI), the substitution of Mo (V) ions to Fe (III), in contrast to buckyballs based on Mo (V). The absence of accumulation of molybdenum in rats with a daily intramuscular injection of aqueous solutions of both drugs within a month was confirmed.

Cite this paper
nullOstroushko, A. , Danilova, I. , Gette, I. , Medvedeva, S. , Tonkushina, M. , Prokofieva, A. and Morozova, M. (2011) Study of Safety of Molybdenum and Iron-Molybdenum Nanoclaster Polyoxometalates Intended for Targeted Delivery of Drugs. Journal of Biomaterials and Nanobiotechnology, 2, 557-560. doi: 10.4236/jbnb.2011.225066.
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