Back
 AJAC  Vol.2 No.8 , December 2011
Temperature and Pressure Behaviours of Methanol, Acetonitrile/Water Mixtures on Chromatographic Systems
Abstract: Temperature and pressure were shown to vary significantly with solvent mixing, showing maxima at differ-ent solvent ratios. Acetonitrile/water mixing resulted in temperature reduction of solutions whereas metha-nol/water mixing caused temperature increases. On the other hand, maximum recorded chromatographic pressure of acetonitrile:water mixtures occurred at a solvent ratio of 1:6 compared with methanol:water, which showed a maximum pressure at a solvent ratio of 1:1. These findings can be of use in stabilizing re-tention time shifts during HPLC-based studies associated with compound identification based on retention time such as analysis of complex mixtures.
Cite this paper: nullT. Aburjai, M. Alzweiri and Y. Al-Hiari, "Temperature and Pressure Behaviours of Methanol, Acetonitrile/Water Mixtures on Chromatographic Systems," American Journal of Analytical Chemistry, Vol. 2 No. 8, 2011, pp. 934-937. doi: 10.4236/ajac.2011.28108.
References

[1]   E. Bulemela, P. Tremaine and S.-I. Ikawa, “Volumetric Behavior of Water-Methanol Mixtures in the Vicinity of the Critical Region,” Fluid Phase Equilibria, Vol. 245, 2006, p. 125.

[2]   K. F. Ita McStravick, J. Lambert, N. Teahan and W. Earle Waghorne, “Enthalpy of Transfer of -CH2- between Water and Organic Solvents or Mixed Aqueous Organic Solvents or Mixed Aquoues Organic Solvent Systems,” Journal of Molecular Liquids, Vol. 94, 2001, pp. 145- 153.

[3]   G. R. Behbehani, S. Ghammamy and W. E. Waghorne, “Enthalpies of Transfer of Acetonitrile from Water to Aqueous Methanol, Ethanol and Dimethylsulphoxide Mixtures at 298.15 K,” Thermochimica Acta, Vol. 448, No. 1, 2006, pp. 37-40. doi:10.1016/j.tca.2006.06.021

[4]   M. Vosough and A. Salemi, “Second-Order Standard Addition for Deconvolution and Quantification of Fatty Acids of Fish Oil Using GC-MS,” Talanta, Vol. 73, No. 1, 2007, pp. 30-36. doi:10.1016/j.talanta.2007.02.025

[5]   M. Bechtold, A. Felinger, M. Held and S. Panke, “Adsorption Behavior of a Teicoplanin Aglycone Bonded Stationary Phase under Harsh Overload Conditions,” Journal of Chromatography A, Vol. 1154, No. 1-2, 2007, pp. 277-286. doi:10.1016/j.chroma.2007.03.103

[6]   D. Bylund, R. Danielsson, G. Malmquist and K. E. Markides, “Chromatographic Alignment by Warping and Dynamic Programming as a Pre-Processing Tool for PARAFAC Modelling of Liquid Chromatography-Mass Spectrometry Data,” Journal of Chromatography A, Vol. 961, No. 2, 2002, pp. 237-244. doi:10.1016/S0021-9673(02)00588-5

[7]   K. M. Pierce, B. W. Wright and R. E. Synovec, “Unsupervised Parameter Optimization for Automated Retention Time Alignment of Severely Shifted Gas Chromatographic Data Using the Piecewise Alignment Algorithm,” Journal of Chromatography A, Vol. 1141, No. 1, 2007, pp. 106-116. doi:10.1016/j.chroma.2006.11.101

[8]   F. Gong, Y.-Z. Liang, Y.-S. Fung and F.-T. Chau, “Correction of Retention Time Shifts for Chromatographic Fingerprints of Herbal Medicines,” Journal of Chromatography A, Vol. 1029, No. 1-2, 2004, pp. 173-183. doi:10.1016/j.chroma.2003.12.049

[9]   F. O. Andersson, R. Kaiser and S. P. Jacobsson, “Data Preprocessing by Wavelets and Genetic Algorithms for Enhanced Multivariate Analysis of LC Peptide Mapping,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 34, No. 3, 2004, pp. 531-541. doi:10.1016/S0731-7085(03)00583-1

[10]   K. J. Johnson, B. W. Wright, K. H. Jarman and R. E. Synovec, “High-Speed Peak Matching Algorithm for Retention Time Alignment of Gas Chromatographic Data for Chemometric Analysis,” Journal of Chromatography A, Vol. 996, No. 1-2, 2003, pp. 141-155. doi:10.1016/S0021-9673(03)00616-2

[11]   A. M. van Nederkassel, M. Daszykowski, P. H. C. Eilers and Y. V. Heyden, “A Comparison of Three Algorithms for Chromatograms Alignment,” Journal of Chromatography A, Vol. 1118, No. 2, 2006, pp. 199-210. doi:10.1016/j.chroma.2006.03.114

[12]   M. Makela and L. Pyy, “Effect of Temperature on Retention Time Reproducibility and on the Use of Programmable Fluorescence Detection of Fifteen Polycyclic Aromatic Hydrocarbons,” Journal of Chromatography A, Vol. 699, No. 1-2, 1995, pp. 49-57. doi:10.1016/0021-9673(95)00120-C

[13]   W. S. Gardner, H. A. Bootsma, C. Evans and P. A. S. John, “Improved Chromatographic Analysis of 15N:14N Ratios in Ammonium or Nitrate for Isotope Addition Experiments,” Marine Chemistry, Vol. 48, No. 3-4, 1995, pp. 271-282. doi:10.1016/0304-4203(94)00060-Q

[14]   M. Alzweiri, J. Parkinson, D. Watson and S. Steer, “Microscopic Trends in Methanol/Water and Acetonitrile/ Water Systems,” Jordan Journal of Pharmaceutical Sciences, Vol. 4, 2011, pp. 20-28.

[15]   Y. Satoh and K. Nakanishi, “Theoretical Studies of Acetonitrile-Water Mixtures/Monte Carlo Simulation,” Fluid Phase Equilibria, Vol. 104, 1995, pp. 41-55. doi:10.1016/0378-3812(94)02638-H

 
 
Top