JBM  Vol.6 No.11 , November 2018
Effect of the Routine Varicella Immunization on Herpes Zoster in Japan in the First Half of the Year
Abstract: In Japan, herpes zoster is not monitored officially or nationwide. Recently, the databases of all electronic medical claims nationwide (NDBEMC) have been available for research. We use NDBEMC from April 2011 to March 2015. To evaluate the effects of initiation of routine immunization for varicella in children, we regressed the number of herpes zoster patients on the dummy variable for the routine immunization for varicella in children with and without a linear time trend. The estimated coefficient for the routine immunization for varicella was 0.5157 and its p-value was 0.001. However, if the time trend was added as an explanatory variable, the estimated coefficient for the routine immunization for varicella changed to be -0.039 and its p-value was 0.384. It means that the routine immunization for varicella was 7.8% higher after introduction than before. However, it was presumed to reflect such an upward trend.
Cite this paper: Sugawara, T. , Ohkusa, Y. and Kamei, M. (2018) Effect of the Routine Varicella Immunization on Herpes Zoster in Japan in the First Half of the Year. Journal of Biosciences and Medicines, 6, 30-36. doi: 10.4236/jbm.2018.611004.

[1]   Brisson, M. and Edmunds, W.J. (2003) Epidemiology of Varicella-Zoster Virus in England and Wales. Journal of Medical Virology, 70, S9-S14.

[2]   Garnett, G.P. and Grenfell, B.T. (1992) The Epidemiology of Varicella-Zoste Virus Infections: The Influence of Varicella on the Prevalence of Herpes Zoster. Epidemiology & Infection, 108, 513-528.

[3]   Thomas, S.L., Wheeler, J.G. and Hall, A.J. (2002) Contacts with Varicella or with Children and Protection against Herpes Zoster in Adults: A Case-Control Study. Lancet, 360, 678-682.

[4]   Yih, W.K., Brooks, D.R., Lett, S.M., Jumaan, A.O., Zhang, Z., Clements, K.M., et al. (2005) The Incidence of Varicella and Herpes Zoster in Massachusetts as Measured by the Behavioral Risk Factor Surveillance System (BRFSS) during a Period of Increasing Varicella Vaccine Coverage, 1998-2003. BMC Public Health, 5, 68.

[5]   Brisson, M., Edmunds, W.J., Law, B., Gay, N.J., Walld, R., Brownell, M., et al. (2001) Epidemiology of Varicella Zoster Virus Infection in Canada and the United Kingdom. Epidemiology & Infection, 127, 305-314.

[6]   Brisson, M., Gay, N.J., Edmunds, W.J. and Andrews, N.J. (2002) Exposure to Varicella Boosts Immunity to Herpes-Zoster: Implications for Mass Vaccination against Chickenpox. Vaccine, 20, 2500-2507.

[7]   Goldman, G.S. (2005) Cost-Benefit Analysis of Universal Varicella Vaccination in the U.S. Taking into Account the Closely Related Herpes-ZOSTER epidemiology. Vaccine, 23, 3349-3355.

[8]   Arruti, M., Pineiro, L.D., Salicio, Y., Cilla, G., Goenaga, M.A. and López de Munain, A. (2017) Incidence of Varicella Zoster Virus Infections of the Central Nervous System in the Elderly: A Large Tertiary Hospital-Based Series (2007-2014). Journal of Neurovirology, 23, 451-459.

[9]   Varghese, L., Standaert, B., Olivieri, A. and Curran, D. (2017) The Temporal Impact of Aging on the Burden of Herpes Zoster. BMC Geriatrics, 17, 30.

[10]   Toyama, N. and Shiraki, K. (2009) Epidemiology of Herpes Zoster and Its Relationship to Varicella in Japan: A 10-Year Survey of 48,388 Herpes Zoster Cases in Miyazaki Prefecture. Journal of Medical Virology, 81, 2053-2058.

[11]   Akabane, N. (2018) Utilization of Big Data in Medicine, Especially Using National Database of Electronic Medical Claims and Health Check-Up for Metabolic Syndrome. (In Japanese)

[12]   Gershon, A.A., LaRussa, P., Steinberg, S., et al. (1996) The Protective Effect of Immunologic Boosting against Zoster: An Analysis in Leukemic Children Who Were Vaccinated against Chickenpox. The Journal of Infectious Diseases, 173, 450-453.

[13]   Hales, C.M., Harpaz, R., Joesoef, M.R., et al. (2013) Examination of Links between Herpes Zoster Incidence and Childhood Varicella Vaccination. Annals of Internal Medicine, 159, 739-745.

[14]   Donahue, J.G., Kieke, B.A., Gargiullo, P.M., et al. (2010) Herpes Zoster and Exposure to the Varicella Zoster Virus in an Era of Varicella Vaccination. American Journal of Public Health, 100, 1116-1122.

[15]   Chaves, S.S., Santibanez, T.A., Gargiullo, et al. (2007)Chickenpox Exposure and Herpes Zoster Disease Incidence in Older Adults in the U.S. Public Health Reports, 122, 155-159.

[16]   Poletti, P., Melegaro, A., Ajelli, M., et al. (2013) Perspectives on the Impact of Varicella Immunization on Herpes Zoster. A Model-Based Evaluation from Three European Countries. PLoS ONE, 8, e60732.

[17]   Oxman, M.N., Levin, M.J., Johnson, G.R., et al. (2005) A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults. New England Journal of Medicine, 352, 2271-2284.

[18]   Tseng, H.F., Smith, N., Harpaz, R., et al. (2011) Herpes Zoster Vaccine in Older Adults and the Risk of Subsequent Herpes Zoster Disease. JAMA, 305, 160-166.

[19]   Langan, S.M., Smeeth, L., Margolis, D.J. and Thomas, S.L. (2013) Herpes Zoster Vaccine Effectiveness against Incident Herpes Zoster and Post-Herpetic Neuralgia in an Older US Population: A Cohort Study. PLoS Medicine, 10, e1001420.