Acute upper digestive bleeding (AUDB)) is a medico-surgical emergency that deserves a careful management regardless of its abundance and mode of revelation.
It remains, despite all the technical progress, a real vital threat because the global mortality still remains from 5% to 30% according to the series   .
According to French studies, its annual incidence is roughly estimated about 100 to 150 episodes per 100,000 inhabitants   .
In another French study conducted, the main causes were gastroduodenal ulcers (30.27%), portal hypertension (26.8%) and oesophagitis (21.57%)  .
In Africa hospital frequencies reported from different countries are almost comparable with those 5.3% in Tunisia, 3.6% in Morocco, 1.2% in Burkina-Faso, 3.1% in Madagascar and 7.3% in Togo, 2% in Benin  -  .
In Mali, this subject has been reported by none recent several studies     . Since AUDB is still a common finding in our context, we conducted this study to update data on their epidemiological, clinical, etiological and prognostic aspects.
2. Patients and Methods
The study was prospective in the hepato-gastroenterology teaching department of Gabriel Touré hospital in Bamako, from March 2013 to January 2014.
We included all patients having Acute Upper Digestive bleeding externalized by hematemesis, rectorragie or melena or the association of the three signs in the period of the study without any other criteria.
Patients were interviewed for a history of blood transfusion, jaundice, toxic use (tobacco, alcohol, gastrotoxic drugs).
The examination appreciated the signs of portal hypertension and hepatocellular deficiency and haemodynamic repercussion of the haemorrhage.
Upper digestive endoscopy after hemodynamic stabilistion allowed searched the cause of the bleeding and the stigmata of recent bleeding.
Hemoglobin and hematocrit levels were assessed for blood spoliation in order to decide blood transfusion.
The early evolution was appreciated by hemorrhage stopping or its recurrence of or the death of the patient.
All data were collected on a survey form and analyzed on epi-info (version 6.0). The Chi-square test was used to compare our results which were significant for a probability p < 0.05.
During our study, 63 patients presented AUDB among 954 hospitalized patients that is to say a frequency of 6.7%.
The male sex was predominant with 49 patients (77.8%) against 14 women (22.2%), a sex ratio of 3.5.
The average age was 45 ± 16.57 years with extremes of 15 and 84 years.
The age group from 46 to 55 was more represented with 15 cases (23.9%) (Table 1).
Shopsellors, farmors and housewives accounted for 63.5% of the sample.
Table 1. Age group.
Tobacco use, epigastralgia and gastrotoxic drug use were more reported in the history with respectively 14 (22.3%), 10 (15.9%) and 4 (6.3%) patients. However, hematemesis occurred in 24 (38.1%) patients without any historic antecedent (Table 2). No known cases of hepatopathy or peptic ulcer (PU) have been reported.
At the admission, dizziness, asthenia, decreased blood pressure, and acelerated pulse were the most common signs of intolerance (Table 3). The physical examination reported pallor (48 patients), ascites (19 patients), jaundice (15 patients), hepatic encephalopathy (11 patients), splenomegaly (10 patients), hepatomegaly (06 patients) and collateral venous circulation (CVC) (06 patients).
The upper digestive endoscopy preferred in the first 6 hours or even 24 hours was the most often performed beyond 24 hours.
Esophageal varices (EV) and peptic ulcer (PU) were the most common endoscopic lesions, respectively 34 cases (57.6%) and 18 cases (30.5%) (Table 4). Cirrhosis has been exclusively the cause of portal hypertension (PHT). Four patients died before upper gastrointestinal endoscopy, were retained in the study for epidemiological and clinical data.
A blood transfusion was performed in 39 patients with an average of 2.4 blood bags of 250 ml (range 1 - 4 pouches) but it did not influence the prognosis (p = 0.8308). Any endoscopic haemostasic treatment was performed because it is not available in the context of the study.
The spontaneous bleeding stopping was observed in 46 patients (73%) and early recurrence occurred in 7 patients (11.1%) including 4 EV breaks, 2 PU and traumatic lesion of the esophagus. Global mortality was 9/63 patients (14.3%) including 4 patients who could not be explored (cited above) and 5 cases of early haemorrhagic recurrence (2 cases of rupture of EV, 2 cases PU, one traumatic lesion case of the esophagus).
The limitation of the study was the number of the sample and some patients had low financial possibility to assess the liver disease. Four patients died before
Table 2. Patient history.
AHT: arterial hypertension; NSAIDs: none steroïd anti-inflammatory drugs.
Table 3. Signs of intolerance at admission.
Table 4. Lesions found at endoscopy.
*Both lesions were associated with some patients; *1 gastric seat: 12 cases; Duodenal seat: 6 fish case.
digestive endoscopy and the causes of the bleeding did not reported in theses cases. We collected 63 cases of upper gastrointestinal bleeding, which accounted for 6.7% of hospitalizations over an 11-month period. This frequency is considerable in a context where the means of haemostasis (pharmacological and endoscopic) are not available. However, the data collected made it possible to evaluate the epidemiology, the clinical picture, the etiologies and the prognosis of these haemorrhages. This frequency is similar to those found by Diarra et al.  and Bagny et al.  which were respectively 5.55% and 7.32%, but higher than those found in some African studies between 2% and 3%, 6%     .
These differences in frequency can be explained by a recruitment bias because of the durations of the studies are not identical.
The male predominance of gastrointestinal bleeding is reported in several African series        probably related to the easy access of men to the toxic (tobacco, NSAID). In addition, the high incidence of PHT-producing liver disease is reported in humans  .
The average age of occurrence of gastrointestinal bleeding in our study (45 years) is similar to that of some African studies that were 48 years  and 47.45 years  but lower than that found by Zohra 51 years  .
The high prevalence among farmers and housewives could be explained by the promiscuity that favors the human-to-human transmission of the hepatitis B virus. This fact is justified by the frequency of EV rupture caused by PHT in relation to cirrhosis. B. Horizontal transmission, horizontal transmission, inter-individual of this virus is known. Tobacco was the most recovered toxicant with 22.3% of cases and could intervene in the determinism of PU frequently found in this study and explained the male predominance. The gastro-toxic drugs were found in our study in 6.3% of cases comparable to the frequency of Razafimahefa et al. which was 7.6%  but lower than that of Bagny et al. which was 17%  . The signs of intolerance of anemia were found in most of our patients and this finding was reported by N’Tagirabiri et al.  and Razafimahefa et al.
Rupture of oesophageal varices was the leading cause of upper digestive haemorrhage found in 57.6% of cases followed by peptic ulcer with 30.5% of cases, most likely because of the frequency of infection with the gastrointestinal ulcer HBV and Helicobacter pylori infection in the general population. This finding confirms the study by Diarra et al.  who found respectively 55.2% and 12.8%. These results are different from those of N’Tagirabiri et al. (28.2% and 46.1%)  and Razafimahefa et al.  who found 40.32% PU and 38.76 indeterminate causes. In our study, no lesion in digestive endoscopy was found in 3.4% of cases, probably due to fugitive lesions by NSAIDs justifying the early inputs of endoscopy.
Rupture of oesophageal varices was the leading cause of upper digestive haemorrhage found in 57.6% of cases followed by peptic ulcer with 30.5% of cases, most likely because of the frequency of infection with the gastrointestinal ulcer. HBV and Helicobacter pylori infection in the general population. This finding confirms the study by Diarra et al.  who found respectively 55.2% and 12.8%. These results are different from those of N’Tagirabiri et al. (28.2% and 46.1%)  and Razafimahefa et al.  who found 40.32% PU and 38.76 indeterminate causes. In our study, no lesion in digestive endoscopy was found in 3.4% of cases, probably due to fugitive lesions by NSAIDs justifying the early inputs of endoscopy.
In 39 patients, a transfusion was indicated but it did not influence the prognosis (p = 0, 8308). The same observation was made by Maiga et al.  . The immediate course was favorable in 73% of the cases after a resuscitation associating with a vascular filling, an administration of PPI, an antibiotherapy, the hemostatic treatment not being available. This rate is not identical with those of Diarra et al.  and N'Tagirabiri et al.  which were respectively 77.6% and 77.1%.
The mortality of digestive haemorrhages in our series was 14.3%. Higher mortality was reported by Diarra et al. (22.4%)  and N’Tagirabiri et al. (22.9%)  .
This mortality is linked in our series to the early recurrence of hemorrhage and also to the most often cirrhotic terrain whereas for Diarra et al.  and Razafimahefa et al.  it seems to be linked to certain lesions, in particular gastric tumors and rupture of oesophageal varices.
Acute high digestive hemorrhages remain frequent and serious in our context. The availability of specific hemostatic treatment could have reduced overall mortality. In addition, the prevention of infection with hepatitis viruses and the fight against self-medication could reduce the frequency and therefore the mortality of these accidents.
 Pateron, D. and Belhadj, K. (2001) Management of Acute Upper Digestive Bleedings: Hemostatic Medecine Use Prise en charge des hémorragies digestives aiguës hautes. Reanimation, 10, 666-672.
 Hagège, H., Latrive, J.P., Nalet, B., et al. (2012) Communautary Uger Digestive Bleedings: Preliminary Results of the ANGH Study among under 1000 Patients. JFHOD, Paris, France.
 Razafimahefa, S.H., Rabenjanahary, T.H., Rakotozafindraibe, R., et al. (2011) Upper Digestive Bleedings: Clinical, Endoscopic et évolutive Aspect. About 62 Malgache Patients. La Revue Médicale de Madagascar, 1, 6-10.
 Bagny, A., Bouglouga, O., Djibril, M.A., et al. (2012) Etiological Profile of Upper Dgestive Bleeding at CHU-Campus of Lomé (Togo). Journal Africain d'Hépato-Gastroentérologie, 6, 38-42.
 N’ Tagirabiri, R., Mumana, A., Dunduri, D., et al. (2012) Upper Digestive Bleedinds in Adult in Burundi: Epidemiological, Etiological, Therapeutic and Evolutive Aspects. Journal Africain d'Hépato-Gastroentérologie, 6, 272-275.