OJCD  Vol.8 No.3 , September 2018
Increased Risk of Bartonella Infections in Humans
Abstract: Bartonellosis has emerging zoonoses of the Vector Borne Diseases (VBD) complex. Progress in evolution and changes of causer, enabled the expansion, and increased number of clinically manifest forms of disease appearance of severe disseminated forms of infections and co-infections in humans, difficult for diagnosis, therapy and prognosis. The Bartonellosis may have a benign and self-limiting evolution in a host, or potentially fatal infections. Etiological agents can provoke a granulomatous or an angioproliferative histology damages. In severely immunodeficient cases (pulmonary tuberculosis, carcinomatosis, HIV infection, patients who underwent organ transplantation etc.), Bartonella infections can be difficult and often with unpredictable course of the fatal prognosis. Present the large specter of clinical manifestations: prolonged fever, erythema nodosum like syndrome, and the other skin manifestations, sub-acute bacterial endocarditis, difficult pulmonary disturbances, bacillary angiomatosis (BA) and hepatic peliosis (HP), bacteriemia or a combination of these. In period 2007-2015 on Clinic for Infectious Diseases in Podgorica, 25 cases with Bartonella infection were diagnosed. In total sample, the most frequent were diagnosed CSD in 19 cases. During 2015 in two cases with HIV/AIDS infection, BA was diagnosed, and in four cases PH was diagnosed.
Cite this paper: Andric, B. , Velkovski, A. , Jovanovic, M. , Markovic, M. and Golubovic, M. (2018) Increased Risk of Bartonella Infections in Humans. Open Journal of Clinical Diagnostics, 8, 25-45. doi: 10.4236/ojcd.2018.83004.

[1]   Dehio, C. and Sander, A. (1999) Bartonella as Emerging Pathogens. Trends in Microbiology, 7, 226-228.

[2]   Chomel, B.B. and Kasten, R.W. (2010) Bartonellosis, an Increasingly Recognized Zoonosis. Journal of Applied Microbiology, 109, 743-750.

[3]   Breitschwerdt, E.B., Maggi, R.G., Chromel, B.B., et al. (2010) Bartonellosis: An Emerging Infectious Disease of Zoonotic Importance to Animals and Human Beings. Journal of Veterinary Emergency and Critical Care, 20, 8-30.

[4]   Boulouis, H.J., Chang, C.C., Henn, J.B., Kasten, R.W. and Crommel, B.B. (2005) Factors Associated with the Rapid Emergence of Zoonotic Bartonella Infections. Veterinary Research, 36, 383-410.

[5]   Maguina, C. and Gotuzzo, E. (2000) Bartonellosis New and Old Infectious Diseases. Medical Clinics of North America, 14, 1-22.

[6]   Breitschwerdt, E.B. (2014) Bartonellosis: One Health Perspectives for an Emerging Infectious Desseases. ILAR Journal, 55, 46-48.

[7]   Drancourt, M., Birtles, R., Chaumentin, G., Vandenesch, F., Etienne, J. and Raoult, D. (1996) New Serotype of Bartonella Henselae in Endocarditis and Cat-Scratch Disease in Endocarditis and Cat-Scratch Disease. The Lancet, 347, 441-443.

[8]   Chomel, B.B., Boulouis, H.J., Breitschwerdt, EB., et al. (2009) Ecological Fitness and Strategies of Adaptation of Bartonella Species to Their Hosts and Vectors. Veterinary Research, 40, 29.

[9]   Kosoy, M., Bai, Y., Lyndi, T., Kuymin, I., Niezgoda, M., Franka, R., Aqwanda, B., Breiman, R. and Rupeerecht, R. (2010) Bartonella spp. in Bats, Kenya. Emerging Infectious Diseases, 16, 1875-1881.

[10]   Diaz, M.H., Baty, Y., Malania, L., Winchell, J.M. and Kosay, M.Y. (2012) Development of a Novel Genus Species and Genotypes. Journal of Clinical Microbiology, 50, 1186.

[11]   Maggi, R.G., Kosoy, M., Mintzer, M. and Breischwerdt, E.B. (2009) Isolation of Candidatus Bartonella melophagi from Human Blood. Emerging Infectious Diseases, 15, 66-68.

[12]   Lin, E.Y., Tsigrelis, C., Baddour, L.M., Lepidi, H., Rolain, J.M., Patel, R., et al. (2010) Candidatus Bartonella mayotimonensis and Endocarditis. Emerging Infectious Diseases, 16, 500-503.

[13]   Mulinsk, K.E., Hang, J., Jiang, J., et al. (2013) Molecular Typing of “Candidates Bartonella ancashi”, a New Human Pathogen Causing Verruga Peruana. Journal of Clinical Microbiology, 51, 3865-3881.

[14]   Bass, J.W., Vincent, J.M. and Person, D.A. (1997) The Expanding Spectrum of Bartonella Infections: II. Cat Scrach Disease. The Pediatric Infectious Disease Journal, 16, 157-163.

[15]   Vander Heyden, T.R., Young, S.L., Breitschwerdt, E.B., et al. (2012) Granulomatous Hepatitis Due to Bartonella hensellae Infection in an Immune-Competent Patient. BMC Infectious Diseases, 12, 17.

[16]   Leong, S.S., Cazen, R.A., Yu, G.S., et al. (1992) Bartonella henselae Species nov a Cause of Septicemia, Bacillary Angiomatosis and Parenchymal Bacillary Peliosis. Journal of Clinical Microbiology, 30, 275-280.

[17]   Marie, J.L., Fournie, P.E., Rolain, J.M., Briolant, S., Daoust, B. and Raoult, D. (2006) Molecular Detection of B. quintana, B. elisabete, B. koehleae, B. doshine, B. taylorii and R. felis in Rodents, Fleas Collected in Kabul, Afganistan. The American Journal of Tropical Medicine and Hygiene, 74, 436-439.

[18]   Inone, K., Kabeya, H., Hiratory, H., Ueda, K., Kosay, M., Chromel, B., Boulouis, H. and Maruyama, S. (2010) Bartonella japonica sp. Now and Bartonella silvatica sp. Now Isolated from Apodemus Mice. International Journal of Systematic and Evolutionary Microbiology, 60, 759-763.

[19]   Gundi, V., Taylor, C., Raoult, D. and La Scola, B. (2009) Bartonella rattaustralieni sp. Now, Bartonella queendensis spp. Now and Bartonella coopersplainsensis spp. Now, Identifier in Australian Rats. 59, 2956-2961.

[20]   Podsiadly, E., Chmielewski, T. and Tylewska-Weirzbanowska, S. (2003) Bartonella hensellae and Borrelia burgdorferi Infections of the Central Nervous System. Annals of the New York Academy of Sciences, 990, 404-406.

[21]   Maggi, R.G., Mozayeni, B.R., Pultorak, E.L., et al. (2012) Bartonella Species Bacteriemia and Rheumatic Symptoms in Patients from Lyme Disease Endemic Region. Emerging Infectious Diseases, 18, 783-791.

[22]   Siciliano, R.F., Strabelli, T.M., Zeigler, R., et al. (2006) Infective Endocarditis Due to Bartonella Species and Coxiella burnetii: Experience at a Cardiology Hospital in Sao Paulo, Brasil. Annals of the New York Academy of Sciences, 1078, 215-222.

[23]   Shahss, S.S. and Mc Gowan, J.P. (2003) Rickettsial, Ehrlichial and Bartonella Infections of the Myocardium and Pericardium. Frontiers in Bioscience, 8, 291-297.

[24]   Berghoff, W. (2012) Chronic Lyme Disease and Co-Infections: Differential Diagnosis. The Open Neurology Journal, 6, 158-178.

[25]   Carithers, H.A. (1970) Cat-Scratch Disease: Notes on Its History. American Journal of Diseases of Children, 119, 200-203.

[26]   Lamps, L.W. and Scott, M.A. (2004) Cat-Scratch Disease: Historic, Clinical, and Pathologic Perspectives. American Journal of Clinical Pathology, 121, 571-581.

[27]   Chain, K.S. and Kosoy, M. (2010) Analysis of Multi-Stain Bartonella Pathogens in Natural Host Population—Do They Behave as Species or Minor Genetic Variants? Epidemics, 2, 165-172.

[28]   Adamska, M. (2010) Bartonella Species as a Zoonotic Pathogens Transmiting by Blood-Feeding. Wiadomosci Parazytologiczne, 56, 1-9.

[29]   Izri, A., Depaquit, J. and Parola, P. (2006) Phlebotominae sandfly and Transmission of Disease Agents Arund the Mediteranean Basin. Médecine Tropicale: Revue du Corps de santé colonial, 66, 249-435.

[30]   Mosbacher, M.E., Klotz, S. and Pinnas, J.Z. (2011) Bartonella henselae and the Potential for Arthropod Vector Borne Transmission. Vector-Borne and Zoonotic Diseases, 11, 471-477.

[31]   Kim, C.M., Kim, J.Y., Yi, Y.H., Lee, M.R., Cho, M.R., Shah, D.H., et al. (2005) Detection of Bartonella Species from Tick, Mites and Small Mammals in Korea. Journal of Veterinary Science, 6, 327-334.

[32]   Swanson, S.J., Neitzel, D., Reed, K.D. and Belongia, E.A. (2006) Coinfections Acquired from Ixodes Ticks. Clinical Microbiology Reviews, 19, 708-727.

[33]   Alsmark, C.M., Frank, A.C., Karlberg, E.O., Legault, B.A., Ardell, D.H., Canback, B., Erikson, A.S., Naslund, A.K., Handley, S.A., Huvet, M., La Scola, B., Holmberg, M. and Anderson, S.G. (2004) The Louse-Borne Human Pathogen Bartonella quintana Is a Genomic Derivative of the Zoonotic Agent Bartonella henselae. Proceedings of the National Academy of Sciences of the United States, 101, 9716-9721.

[34]   Hercik, K., Hasova, V., Janecek, J. and Branny, P. (2007) Molecular Evidence of Bartonella DNA in Ixodes Ticks in Czechia. Folia Microbiologica, 52, 503-509.

[35]   Cotté, V., Bonnet, S., Le Rhun, D., Le Naour, E., Chauvin, A., Boulouis, H.J., et al. (2008) Transmission of Bartonella henselae by Ixodes ricinus. Emerging Infectious Diseases, 14, 1074-1080.

[36]   La Scola, B., Holmberg, M. and Raoult, D. (2004) Lack of Bartonella Species in 167 Ixodes ricinus Ticks Collected in Central Sweden. Scandinavian Journal of Infectious Diseases, 36, 305-306.

[37]   Schouls, L.M., Van De Pol, I., Rijpkema, S.G. and Schot, C.S. (1999) Detection and Identification of Ehrlichia, Borrelia burgdorferi sensu lato, and Bartonella Species in Dutch Ixodes ricinus Ticks. Journal of Clinical Microbiology, 37, 2215-2222.

[38]   Liston, T.E. and Koechler, J.E. (1996) Granulomatous Hepatitis and Necrotizing Splenitis Due to Diagnosed with Chronic Lyme Disease: A Systematic Literature Review of Hepatosplenic Manifestations of Bartonella Infection. Clinical Infectious Diseases, 22, 951-957.

[39]   Paul, M., Lantos, M.D., Gary, P. and Wormser, M.D. (2014) Chronic Coinfections in Patients Diagnosed with Chronic Lyme Disease: A Systematic Literature Review. American Journal of Medicine, 127, 1105-1110.

[40]   Welc-Faleciak, R., Hildevbrandt, A. and Sinski, E. (2010) Co-Infection with Borrelias Species and Other Tick-Borne Pathogens in Humans, Two Cases from Poland. Annals of Agricultural and Environmental Medicine, 17, 303-313.

[41]   Hornef, M.W., Wick, M.J., Rhen, M. and Normaek, S. (2002) Bacterial Strategies for Overcoming Host Innate and Adaptive Immune Responss. Nature Immunology, 3, 1033-1040.

[42]   Eskswo, E., Rao, R.V. and Mordechia, E. (2001) Concurrent Infection of the Central Nervous System by Borrelia burgdorferi and Bartonella henselae: Evidence for a Novel Tick-Borne Disease Complex. Archives of Neurology, 58, 1357-1363.

[43]   Pons, I., Sanfeliu, I., Cardenosa, N., Nogueras, M.M., Font, B. and Segura, F. (2008) Serological Evidence of Bartonella henselae Infection in Healthy People in Catalonia, Spain. Epidemiology & Infection, 136, 1712-1716.

[44]   Maurin, M. and Raoult, D. (1998) Bartonella Infections: Diagnostics and Management Issues. Current Opinion in Infectious Diseases, 11, 189-193.

[45]   Iannaccone, R., Federle, M.P., Brancatelli, G., et al. (2006) Peliosis Hepatis: Spectrum of Imaging Findings. American Journal of Roentgenology, 187, W43-W52.

[46]   Koehler, J.E., Sanchez, M.A., Garrido, C.S., Whitfeld, M.J., Chen, F.M., Berger, T.G., Rodriguez-Barradas, M.C., Le Boit, P.E. and Tappero, J.W. (1997) Molecular Epidemiology of Bartonella Infections in Patients with Bacillary Angiomatosis-Peliosis. The New England Journal of Medicine, 337, 1876-1883.

[47]   Ahsan, N., Holman, M.J., Riley, T.R., et al. (1998) Peloisis Hepatis Due to Bartonella henselae in Transplantation: A Hemato-Hepato-Renal Syndrome. Transplantation, 65, 1000.

[48]   Plettenberg, A., Lorenzen, T., Burtsche, B.T., et al. (2000) Bacillary Angiomatosis in HIV-Infected Patients—An Epidemiological and Clinical Study. Dermatology, 201, 326.