AID  Vol.8 No.3 , September 2018
The Epidemiological, Clinical, Paraclinical and Prognostic Aspects of Severe Malaria at the Regional Hospital of Thies
Abstract: Introduction: Malaria, the first parasitical endemic disease in the world, is a serious disease with 407,000 deaths in Africa in 2016. It is the main cause of morbidity and mortality in Senegal [1] [2]. Methods: Our retrospective study carried out from 1st January 2010 to 31 December 2013, at the department of internal medicine in the regional hospital of Thies was aimed at studying the epidemiological, clinical, paraclinical and prognostic profile of severe malaria in the autochthonous adults with 15 years and more. Results: Over this 3-year period, 57 patients were hospitalized in 1275 patients due to severe malaria that is to say a hospital prevalence of 4.47%. The average age was 64.21. A clear male predominance has been observed, around 61% (34/57) against 39% (23/57) with a sex ratio of 1.6. The highest malarial infestation rate was found at the end of the rainy season and at the beginning of the dry season (September to November). The clinical picture which predominates is the neurological affection which represented 33.3% of the cases. The different aspects of this neurological affection were of coma type, convulsion and prostration in 87%; 21.7% and 8.6% respectively. The cerebral malaria was associated or not with other symptoms of severity that are anemia in 41.6%; icterus was represented in 21% of the cases, cardio-vascular collapse in 15.8% and hypoglycemia in 5.5% of the cases. The complications were observed during the hospitalization in 73.6% of the cases with the type of bacterial pneumonia (47.6%) and urinary infections (26.2%). The curative treatment was based on quinine salts through intravenous track in 100% of the case with a shift to the Artemisinin combination therapy (ACT) associated with intense care measures. In our study the whole lethality is 17%. Conclusion: The results of our study shows that the severe forms of malaria are still affecting our tropical endemic area, in spite of the prevention efforts made to fight against this plague. This research illustrates the difficulties to provide optimum medical care when combining antimalarial treatment and resuscitative measures in the decentralized reception facilities.
Cite this paper: Lawson, A. , Diop, M. , Cisse, V. , Akanni, S. , Berthe, A. , Toure, P. , Diop, B. and Ka, M. (2018) The Epidemiological, Clinical, Paraclinical and Prognostic Aspects of Severe Malaria at the Regional Hospital of Thies. Advances in Infectious Diseases, 8, 162-171. doi: 10.4236/aid.2018.83015.

[1]   Dièye, A. (2014) Paludisme grave et Infections bactériennes associées au Service des Maladies Infectieuses du CHUN de Fann: Aspects épidémiologiques, cliniques, paracliniques et évolutifs. Thèse Méd, Dakar, 201.

[2]   Ndiaye, F. (2016) Aspects épidémiologiques, cliniques, paracliniques et évolutifs du paludisme grave chez l’adulte au Centre de Santé Silence à Ziguinchor. Thèse Méd, Dakar, 50.

[3]   Diallo, A.H., Ki-Zerbo, G., Sawadogo, A.B., et al. (2014) Paludisme grave et infection à VIH chez l’adulte à Bobo-Dioulasso, Burkina Faso. Médecine Tropicale, 64, 345-350.

[4]   Diop, S.A, Ndour, C.T, Ba, N.M., et al. (2010) Aspects actuels du paludisme grave de l’adulte à la clinique des maladies infectieuses du CHNU de Fann de Dakar (Sénégal). Médecine Afrique Noire, 57, 193-197.

[5]   Gaye, O., Bengua, E., Diallo. S., et al. (1989) Morbidité palustre en milieu rural et urbain au Sénégal. Médecine Tropicale, 49, 59-62.

[6]   Rakotoarivelo, R.A., Raveloson, H.F.R., et al. (2009) Aspects cliniques et thérapeutiques du paludisme grave de l’adulte en milieu hospitalier à Antananarivo, Madagascar. Bulletin de la Société de Pathologie Exotique, 102, 215-216.

[7]   Charra, B., Sodqi, M., Sandali, O. et al. (2007) Paludisme grave d’importation chez l’adulte: étude rétrospective de dix cas admis en réanimation à Casablanca. Médecine et Maladies Infectieuses, 37, 162-165.

[8]   Gupta, B.K., Gupta, A., et al. (2015) Clinical Profile and Prognostic Indicators in Adults Hospitalized with Severe Malaria Caused by Different Plasmodium Species. Infectious Diseases (Auckl), 8, 45-50.

[9]   Sawadogo, M., Ouédraogo, A., Sondo, K.A., et al. (2014) Aspects épidémiologiques,cliniques et thérapeutiques du paludisme au CHU Yalgado Ouédraogo de Ouagadougou, Burkina Faso. Médecine Afrique Noire, 61, 374-378.

[10]   Kempf, J., Diatta, B., Vitris, M., et al. (1994) Severe Malaria in African Adults Living in a Seasonal Endemic Area. Intensive Care Medicine, 20, 437-441.

[11]   Eholié, S.P, Ehui, E., Adou-Bryn, K., et al. (2004) Paludisme grave de l’adulte autochtone à Abidjan (Cote d’Ivoire). Bulletin de la Société de Pathologie Exotique, 97, 340-344.

[12]   Belguiti Alaoui, H. (2011) Paludisme grave de l’adulte: Aspects épidémiologiques, cliniques, para cliniques et évolutifs à propos de 381 cas à la clinique des maladies infectieuses du CNHU de Fann. These Méd Dakar, 56.

[13]   Bruneel, F. (2011) Paludisme grave d’importation. Journal des Anti-infectieux, 13, 39-48.

[14]   English, M., Punt, J., Mwangi, I., et al. (1996) Clinical Overlap between Malaria and Severe Pneumonia in Africa Children in Hospital. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 658-662.

[15]   Imran, R., Devendra Kumar, T., Anjum Mirza, C., et al. (2013) Complications Associated with Plasmodium vivax Malaria: A Retrospective Study from a Tertiary Care Hospital Based in Western Uttar Pradesh. India Annals of African Medicine, 12, 155-159.

[16]   Imtiaz, S., Drohlio, M.F., Nassir, K., et al. (2015) Morbidity and Mortality Associated with Plasmodium vivax and Plasmodium falciparum Infection in a Tertiary Care Kidney. Saudi Journal of Kidney Disease and Transplantation, 26, 1169-1176.

[17]   Sawsan, B. (2013) Hematological Parameters in Severe Complicated Plasmodium falciparum Malaria among Adults in Aden. Turkish Journal of Hematology, 30, 394-399.