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 Health  Vol.10 No.8 , August 2018
Marijuana Use and Depressive Symptoms among Young People: Examining Unidirectional and Bidirectional Effects
Abstract: Research suggests that the prevalence of marijuana use and depression are increasing in the United States. Although it is not entirely clear what accounts for these coincident trends, several studies have shown that these two health concerns are associated among young people. This study assessed four hypotheses regarding the association between marijuana use and depression: 1) whether marijuana use affects subsequent symptoms of depression; 2) whether depressive symptoms affect subsequent marijuana use; 3) whether they are associated in a bidirectional (reciprocal) manner; and 4) whether the association between the two is confounded by stressful life events. Using eight years of longitudinal data from the Family Wellness and Health Study, a fixed-effects regression model provided empirical support for the first hypothesis only, but not for the others. Future research should explore in greater detail why marijuana use may have a causal impact on experiences with depression among young people.
Cite this paper: Hoffmann, J. (2018) Marijuana Use and Depressive Symptoms among Young People: Examining Unidirectional and Bidirectional Effects. Health, 10, 1066-1078. doi: 10.4236/health.2018.108080.
References

[1]   Kerr, W.C., Lui, C. and Ye, Y. (2018) Trends and Age, Period and Cohort Effects for Marijuana Use Prevalence in the 1984-2015 US National Alcohol Surveys. Addiction, 113, 473-481.
https://doi.org/10.1111/add.14031

[2]   Miech, R., Johnston, L. and O’Malley, P.M. (2017) Prevalence and Attitudes Regarding Marijuana Use among Adolescents over the Past Decade. Pediatrics, 140, e20170982.
https://doi.org/10.1542/peds.2017-0982

[3]   Sherburne, M. (2017) National Study Shows Marijuana Use among U.S. College Students at Highest Level in Three Decades. Institute for Social Research, University of Michigan, Ann Arbor, MI.
http://home.isr.umich.edu/releases/mtf-marijuana-2017

[4]   Weinberger, A.H., Gbedemah, M., Martinez, A.M., Nash, D., Galea, S. and Goodwin, R.D. (2017) Trends in Depression Prevalence in the USA from 2005 to 2015: Widening Disparities in Vulnerable Groups. Psychological Medicine, 48, 1308-1315.
https://doi.org/10.1017/S0033291717002781

[5]   Hasin, D.S., Sarvet, A.L., Meyers, J.L., Saha, T.D., Ruan, W.J., Stohl, M. and Grant, B.F. (2018) Epidemiology of Adult DSM-5 Major Depressive Disorder and Its Specifiers in the United States. JAMA Psychiatry, 75, 336-346.
https://doi.org/10.1001/jamapsychiatry.2017.4602

[6]   Kessler, R.C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K.R., Rush, A.J., Walters, E.E. and Wang, P.S. (2003) The Epidemiology of Major Depressive Disorder: Results from the National Comorbidity Survey Replication (NCS-R). JAMA, 289, 3095-3105.
https://doi.org/10.1001/jama.289.23.3095

[7]   Mojtabai, R., Olfson, M. and Han, B. (2016) National Trends in the Prevalence and Treatment of Depression in Adolescents and Young Adults. Pediatrics, 138, e20161878.
https://doi.org/10.1542/peds.2016-1878

[8]   Keith, D.R., Hart, C.L., McNeil, M.P., Silver, R. and Goodwin, R.D. (2015) Frequent Marijuana Use, Binge Drinking and Mental Health Problems among Undergraduates. American Journal on Addictions, 24, 499-506.
https://doi.org/10.1111/ajad.12201

[9]   Low, N.C., Dugas, E., O’Loughlin, E., Rodriguez, D., Contreras, G., Chaiton, M. and O’Loughlin, J. (2012) Common Stressful Life Events and Difficulties are Associated with Mental Health Symptoms and Substance Use in Young Adolescents. BMC Psychiatry, 12, 116.
https://doi.org/10.1186/1471-244X-12-116

[10]   Lev-Ran, S., Roerecke, M., Le Foll, B., George, T.P., McKenzie, K. and Rehm, J. (2014) The Association between Cannabis Use and Depression: A Systematic Review and Meta-Analysis of Longitudinal Studies. Psychological Medicine, 44, 797-810.
https://doi.org/10.1017/S0033291713001438

[11]   Moore, T.H., Zammit, S., Lingford-Hughes, A., Barnes, T.R., Jones, P.B., Burke, M. and Lewis, G. (2007) Cannabis Use and Risk of Psychotic or Affective Mental Health Outcomes: A Systematic Review. The Lancet, 370, 319-328.
https://doi.org/10.1016/S0140-6736(07)61162-3

[12]   Pang, R.D., Farrahi, L., Glazier, S., Sussman, S. and Leventhal, A.M. (2014) Depressive Symptoms, Negative Urgency and Substance Use Initiation in Adolescents. Drug & Alcohol Dependence, 144, 225-230.
https://doi.org/10.1016/j.drugalcdep.2014.09.771

[13]   Hooshmand, S., Willoughby, T. and Good, M. (2012) Does the Direction of Effects in the Association between Depressive Symptoms and Health-Risk Behaviors Differ by Behavior? A Longitudinal Study across the High School Years. Journal of Adolescent Health, 50, 140-147.
https://doi.org/10.1016/j.jadohealth.2011.05.016

[14]   Boden, J.M. and Fergusson, D.M. (2011) Alcohol and Depression. Addiction, 106, 906-914.
https://doi.org/10.1111/j.1360-0443.2010.03351.x

[15]   Volkow, N.D., Wang, G.J., Telang, F., Fowler, J.S., Alexoff, D., Logan, J., Jayne, M., Wong, C. and Tomasi, D. (2014) Decreased Dopamine Brain Reactivity in Marijuana Abusers Is Associated with Negative Emotionality and Addiction Severity. Proceedings of the National Academy of Sciences, 111, E3149-E3156.
https://doi.org/10.1073/pnas.1411228111

[16]   Marmorstein, N.R. (2009) Longitudinal Associations between Alcohol Problems and Depressive Symptoms: Early Adolescence through Early Adulthood. Alcoholism: Clinical and Experimental Research, 33, 49-59.
https://doi.org/10.1111/j.1530-0277.2008.00810.x

[17]   Hoffmann, J.P., Baldwin, S.A. and Cerbone, F.G. (2003) Onset of Major Depressive Disorder among Adolescents. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 217-224.
https://doi.org/10.1097/00004583-200302000-00016

[18]   Hoffmann, J.P. (2010) A Life-Course Perspective on Stress, Delinquency, and Young Adult Crime. American Journal of Criminal Justice, 35, 105-120.
https://doi.org/10.1007/s12103-010-9072-4

[19]   Bachman, J.G., Johnston, L.D., O’Malley, P.M., Schulenberg, J.E. and Miech, R.A. (2015) The Monitoring the Future Project after Four Decades: Design and Procedures. Institute for Social Research, University of Michigan, Ann Arbor.
http://monitoringthefuture.org/pubs/occpapers/mtf-occ82.pdf

[20]   Swearingen, E.M. and Cohen, L.H. (1985) Measurement of Adolescents’ Life Events: The Junior High Life Experiences Survey. American Journal of Community Psychology, 13, 69-85.
https://doi.org/10.1007/BF00923260

[21]   Lavee, Y., McCubbin, H.I. and Olson, D.H. (1987) The Effect of Stressful Life Events and Transitions on Family Functioning and Well-Being. Journal of Marriage and the Family, 49, 857-873.
https://doi.org/10.2307/351979

[22]   Pearlin, L.I. and Schooler, C. (1978) The Structure of Coping. Journal of Health and Social Behavior, 19, 2-21.
https://doi.org/10.2307/2136319

[23]   Rosenberg, M. (1979) Conceiving the Self. Basic Books, New York.

[24]   Olson, D. (2011) FACES IV and the Circumplex Model: Validation Study. Journal of Marital and Family Therapy, 37, 64-80.
https://doi.org/10.1111/j.1752-0606.2009.00175.x

[25]   Van Dam, N.T. and Earleywine, M. (2011) Validation of the Center for Epidemiologic Studies Depression Scale-Revised (CESD-R): Pragmatic Depression Assessment in the General Population. Psychiatry Research, 186, 128-132.
https://doi.org/10.1016/j.psychres.2010.08.018

[26]   Galbraith, S., Bowden, J. and Mander, A. (2017) Accelerated Longitudinal Designs: An Overview of Modelling, Power, Costs and Handling Missing Data. Statistical Methods in Medical Research, 26, 374-398.
https://doi.org/10.1177/0962280214547150

[27]   Bachman, J.G., Wadsworth, K.N., O’Malley, P.M., Johnston, L.D. and Schulenberg, J.E. (2013) Smoking, Drinking, and Drug Use in Young Adulthood: The Impacts of New Freedoms and New Responsibilities. Psychology Press, New York.

[28]   Ryan, T.P. (2008) Modern Regression Methods. New York, Wiley.
https://doi.org/10.1002/9780470382806

[29]   Boardman, J.D., Alexander, K.B. and Stallings, M.C. (2011) Stressful Life Events and Depression among Adolescent Twin Pairs. Biodemography and Social Biology, 57, 53-66.
https://doi.org/10.1080/19485565.2011.574565

[30]   Hoffmann, J.P. (2016) Cumulative Stress and Substance Use from Early Adolescence to Emerging Adulthood. Journal of Drug Issues, 46, 267-288.
https://doi.org/10.1177/0022042616638492

[31]   Tate, S.R., Wu, J., McQuaid, J.R., Cummins, K., Shriver, C., Krenek, M. and Brown, S.A. (2008) Comorbidity of Substance Dependence and Depression: Role of Life Stress and Self-Efficacy in Sustaining Abstinence. Psychology of Addictive Behaviors, 22, 47-57.
https://doi.org/10.1037/0893-164X.22.1.47

[32]   Epstein, M., Hill, K.G., Roe, S.S., Bailey, J.A., Iacono, W.G., McGue, M., Kristman-Valente, A., Catalano, R.F. and Haggerty, K.P. (2017) Time-Varying Effects of Families and Peers on Adolescent Marijuana Use: Person-Environment Interactions across Development. Development and Psychopathology, 29, 887-900.
https://doi.org/10.1017/S0954579416000559

[33]   Musick, K. and Bumpass, L. (2012) Reexamining the Case for Marriage: Union Formation and Changes in Well-Being. Journal of Marriage and Family, 74, 1-18.
https://doi.org/10.1111/j.1741-3737.2011.00873.x

[34]   Brüderl, J. and Ludwig, V. (2015) Fixed-Effects Panel Regression. In: Best, H. and Wolf, C., Eds., The Sage Handbook of Regression Analysis and Causal Inference, Sage, Thousand Oaks, 327-357.

[35]   Hsiao, C. (2014) Analysis of Panel Data. 3rd Edition, Cambridge University Press, New York.
https://doi.org/10.1017/CBO9781139839327

[36]   Allison, P.D. (2009) Fixed Effects Regression Models. Sage, Thousand Oaks.
https://doi.org/10.4135/9781412993869

[37]   Hoffmann, J.P. (2016) Regression Models for Categorical, Count, and Related Variables. University of California Press, Oakland.

[38]   Hankin, B.L., Young, J.F., Abela, J.R., Smolen, A., Jenness, J.L., Gulley, L.D., Technow, J.R., Gottlieb, A.B., Cohen, J.R. and Oppenheimer, C.W. (2015) Depression from Childhood into Late Adolescence: Influence of Gender, Development, Genetic Susceptibility, and Peer Stress. Journal of Abnormal Psychology, 124, 803-816.
https://doi.org/10.1037/abn0000089

[39]   Schuster, R.M., Mermelstein, R. and Wakschlag, L. (2013) Gender-Specific Relationships between Depressive Symptoms, Marijuana Use, Parental Communication and Risky Sexual Behavior in Adolescence. Journal of Youth and Adolescence, 42, 1194-1209.
https://doi.org/10.1007/s10964-012-9809-0

[40]   Ammerman, S., Ryan, S., Adelman, W.P. and Committee on Substance Abuse (2015) The Impact of Marijuana Policies on Youth: Clinical, Research, and Legal Update. Pediatrics, 135, e769-e785.
https://doi.org/10.1542/peds.2014-4147

[41]   Joffe, A. (2017) Understanding the Full Effect of the Changing Legal Status of Marijuana on Youth: Getting It Right. JAMA Pediatrics, 171, 115-116.
https://doi.org/10.1001/jamapediatrics.2016.3920

 
 
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