NS  Vol.3 No.11 , November 2011
Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery
ABSTRACT
The aim of this study was to evaluate the effect of coating of alginate-chitosan (AL:CS) beads on the colonic drug delivery. The AL:CS systems containing triamcinolone (TC) were coated with the HPMCP and Eudragit? L100 by immersion and by spraying methods. The drug release profile in simulated colonic medium was determined using 5% human fecal content suspension in 0.01 N buffer solution, pH 6.8. The systems coated with HPMCP showed a lower rate of drug delivery in simulated enteric medium. The delivery profile in simulated colonic medium followed zero-order kinetic. The coated systems provided a promising drug-delivery profile for application in colonic drug delivery.

Cite this paper
Vier, N. and Lucinda-Silva, R. (2011) Influence of coating on the triamcinolone release of alginate chitosan beads for colonic drug delivery. Natural Science, 3, 955-962. doi: 10.4236/ns.2011.311122.
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