OJOG  Vol.1 No.4 , December 2011
Type I endometrial cancer after chemoradiation therapy for carcinoma of the cervix: a case report
Standard treatment for cervical cancer has been radiation and chemotherapy. Ionizing radiation has been associated with damage to normal tissues included in the radiation field. Post-radiation uterine cancers are characterized by high stage, high grade, and a preponderance of type II histologic subtypes. We report a case of type I endometrioid adenocarcinoma diagnosed 19 years after definitive chemoradiation for cervical cancer.

Cite this paper
nullGupta, V. and Hoekstra, A. (2011) Type I endometrial cancer after chemoradiation therapy for carcinoma of the cervix: a case report. Open Journal of Obstetrics and Gynecology, 1, 226-228. doi: 10.4236/ojog.2011.14044.
[1]   Chaturvedi, A., Engels, E., Gilbert, E., Chen, B., Storm, H., Lynch, C., et al. (2007) Second cancers among 104,760 survivors of cervical cancer: Evaluation of long-term risk. Journal of National Cancer Institute, 99, 1634-1643. doi:10.1093/jnci/djm201

[2]   Kumar, S., Shah, J., Bryant, C., Seward, S., Ali-Fehmi, R., Morris, R., et al. (2009) Radiation-associated endometrial cancer. Obstetrics and Gynecology, 113, 319-325.

[3]   Gallion, H., Van Nagell, J., Donaldson, E. and Powell, D. (1987) Endometrial cancer following radiation therapy for cervical cancer. Gynecologic Oncology, 27, 76-83. doi:10.1016/0090-8258(87)90232-0

[4]   Pothuri, B., Ramondetta, L., Martino, M., Alektiar, K., Eifel, P., Deavers, M., et al. (2003) Development of endometrial cancer after radiation treatment for cervical carcinoma. Obstetrics and Gynecology, 101, 941-945. doi:10.1016/S0029-7844(03)00234-5

[5]   Parkash, V. and Carcangiu, M.L. (1992) Uterine Papillary serous carcinoma after radiation therapy for carcinoma of the cervix. Cancer, 69, 496-501. doi:10.1002/1097-0142(19920115)69:2<496::AID-CNCR2820690237>3.0.CO;2-Q

[6]   Hagiwara, T., Mori, T. and Kaku, T. (2005) Development of endometrial cancer following radiation therapy for cervical carcinoma. European Journal of Gynaecologic Oncology, 26, 191-195.

[7]   Buchholz, T.A. (2003) Lung carcinoma development after radiotherapy for breast carcinoma. Cancer, 98, 1331-1333. doi:10.1002/cncr.11657

[8]   Travis, L.B., Hill, D.A., Dores, G.M., et al. (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. Journal of the American Medical Association, 290, 465-475. doi:10.1001/jama.290.4.465

[9]   Pride, G.L. and Buchler, D.A. (1997) Carcinoma of the vagina 10 or more years following pelvic irradiation therapy. American Journal of Obstetrics Gynecology, 127, 513-517.

[10]   Jereczek-Fossa, B.A., Alterio, D., Jassem, J., et al. (2004) Radiotherapy-induced thyroid disorders. Cancer Treatment Review, 30, 369-384. doi:10.1016/j.ctrv.2003.12.003

[11]   Rodriguez, J. and Hart, W. (1982) Endometrial cancers occurring 10 or more years after pelvic irradiation for carcinoma. International Journal of Gynecological Pathology, 1, 135-144. doi:10.1097/00004347-198202000-00002

[12]   Seidman, J.D., Kumar, D., Cosin, J.A., et al. (2006) Carcinomas of the female genital tract occurring after pelvic irradiation: A report of 15 cases. International Journal of Gynecologic Pathology, 25, 293-297. doi:10.1097/01.pgp.0000189240.03780.b1

[13]   De Hullu, J.A., Pras, E., Hollema, H., et al. (2005) Presentations of endometrial activity after curative radiotherapy for cervical cancer. Maturitas, 51, 172-176. doi:10.1016/j.maturitas.2004.07.005