OJGen  Vol.8 No.2 , June 2018
Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco
Abstract: Purpose: A proportion of cases with repeated abortion are caused by chromosomal abnormality in one of the parents. The purpose of this study was to assess the frequency and nature of chromosomal aberrations that contribute to the occurrence of recurrent miscarriages. Several studies have been done to determine the role of chromosomal abnormalities in couples with recurrent spontaneous abortion in various countries. None of these studies was done in Morocco. Material and Methods: Cytogenetic study was done for 238 Moroccan couples who presented with repeated abortion at the Institut Pasteur, Casablanca, Morocco. Results: We found that the frequency of chromosomal abnormalities was not significantly different from that reported worldwide. Chromosomal abnormalities were detected in 13 (6.1%) of 238 couples. twelve of chromosomal abnormalities were structural and one of them were numerical. Conclusion: This study highlights the importance of constitutional cytogenetic exploration of couples with a history of repeated spontaneous abortion. Cytogenetic findings could provide valuable information for genetic counseling and allow monitoring of future pregnancies by prenatal diagnosis in couples with a history of recurrent miscarriage.
Cite this paper: Houmaid, H. , El Bekkay, C. , Nassereddine, S. , Talbi, H. , Amehdare, L. and Hilali, A. (2018) Chromosomal Abnormalities in 238 Couples with Recurrent Miscarriages in Morocco. Open Journal of Genetics, 8, 15-22. doi: 10.4236/ojgen.2018.82002.

[1]   French, F.E. and Bierman, J.M. (1967) Probabilities of Fetal Mortality. Public Health Reports, 77, 835-847.

[2]   Dejmek, J., Vojtassak, J. and Malova, J. (1992) Cytogenetic Analysis of 1508 Spontaneous Abortions Originating from South Slovakia. European Journal of Obstetrics & Gynecology and Reproductive Biology, 46, 129-136.

[3]   Services 1982 Reproductive Impairment among Married Couples. In: US Vital and Health Statistics Series 23, 11, National Center of Health Statistics, Hyattsrille, 1982.

[4]   Franssen, M.T., Korevaar, J.C., Leschot, N.J., et al. (2005) Selective Chromosome Analysis in Couples with Two or More Miscarriages. British Medical Journal, 331, 137-141.

[5]   Coulam, C.B. (1991) Epidemiology of Recurrent Spontaneous Abortion. American Journal of Reproductive Immunology, 26, 23-27.

[6]   Stephenson, M.D. (1996) Frequency of Factors Associated with Habitual Abortion in 197 Couples. Fertility and Sterility, 66, 24-27.

[7]   Lee, R.M. and Silver, R.M. (2000) Recurrent Pregnancy Loss: Summary and Clinical Recommendations. Seminars in Reproductive Medicine, 18, 433-440.

[8]   Boue, A., Boue, J. and Gropp, A. (1985) Cytogenetics in Pregnancy Wastage. In: Harris, H. and Hirschhorn, K., Eds., Advances in Human Genetics, Vol. 14, Plenum Press, New York, 1-57.

[9]   Fryns, J.P. and Van Buggenhout, G. (1998) Structural Chromosome Rearrangements in Couples with Recurrent Fetal Wastage. European Journal of Obstetrics & Gynecology and Reproductive Biology, 81, 171-176.

[10]   Brackeeleer, M.D. and Dao, T.N. (1990) Cytogenetic Studies in Couples Experiencing Repeated Pregnancy Losses. Human Reproduction, 5, 518-528.

[11]   Clifford, K., Flanagan, A.M. and Regan, L. (1994) An Informative Protocol for the Investigation of Recurrent Miscarriage; Preliminary Experience of 500 Consecutive Cases. Human Reproduction, 9, 1328-1332.

[12]   Gardner, R.J.M. and Sutherland, G.R. (1996) Chromosome Abnormalities and Genetic Counselling. 2nd Edition, Oxford University Press, New York.

[13]   Lindenbaum, R.H. and Bobrow, M. (1975) Reciprocal Translocations in Man: 3:1 Meiotic Disjunction Resulting in 47-45 Chromosome Offspring. Journal of Medical Genetics, 12, 29-43.

[14]   Stene, J. and Stengel-Rutkowski, S. (1982) Genetic Risks for Familial Reciprocal Translocations with Special Emphasis on Those Leading to 9p, 10p, 12p, trisomies. Annals of Human Genetics, 46, 41-47.

[15]   Chandley, A.C., Edmond, P., Christie, S., Gowans, L., Fletcher, J., Frackievicz, A., et al. (1975) Cytogenetics and Infertility in Man. I: Karyotype and Seminal Analysis: Results of a Five-Year Survey of Men Attending a Subfertility Clinic. Annals of Human Genetics, 39, 231-254.

[16]   Neri, G., Serra, A., Campana, M. and Tedeschi, B. (1983) Reproductive Risks for Translocations: Cytogenetic Study and Analysis of Pregnancy Outcome in 58 Families. American Journal of Medical Genetics, 16, 535-561.

[17]   Campana, M., Serra, A. and Neri, G. (1986) Role of Chromosome Aberrations in Recurrent Abortion: A Study of 269 Balanced Translocations. American Journal of Medical Genetics, 24, 341-365.

[18]   Rai, R. and Regan, L. (2006) Recurrent Miscarriage. The Lancet, 368, 601-611.

[19]   Practice Committee of the American Society for Reproductive Medicine (2012) Evaluation and Treatment of Recurrent Pregnancy Loss: A Committee Opinion. Fertility and Sterility, 98, 1103-1111.

[20]   Rowley, P.T., Marshall, R. and Ellis, J.R.A. (1963) Genetic and Cytological Study of Repeated Spontaneous Abortion. Annals of Human Genetics, 27, 78-100.

[21]   Khudr, G. (1974) Cytogenetics of Habitual Abortion: A Review. Obstetrical & Gynecological Survey, 29, 299-310.

[22]   Tharapel, A.T., Tharapel, S.A. and Bannerman, R.M. (1985) Recurrent Pregnancy Losses and Parental Chromosome Abnormalities: A Review. British Journal of Obstetrics and Gynaecology, 92, 899-914.

[23]   Abdalla, E.M. and EL-Kharadly, R.N. (2012) Pericentric Inversion of Chromosome 9 in a Consanguineous Couple with Molar Pregnancies and Spontaneous Abortions. Laboratory Medicine, 43, 212-216.

[24]   Yamada, K. (1992) Population Studies of Inv(9) Chromosomes in 4,300 Japanese: Incidence, Sex Difference and Clinical Significance. The Japanese Journal of Human Genetics, 37, 293-301.

[25]   Sípek, A., Panczak, A., Mihalová, R., Hrcková, L., Suttrová, E., Sobotka, V., et al. (2015) Pericentric Inversion of Human Chromosome 9 Epidemiology Study in Czech Males and Females. Folia Biologica, 61, 140-146.

[26]   Goud, T.M., Mohammed Al Harassi, S., Khalfan Al Salmani, K., Mohammed Al Busaidy, S. and Rajab, A. (2009) Cytogenetic Studies in Couples with Recurrent Miscarriage in the Sultanate of Oman. Reproductive BioMedicine Online, 18, 424-429.

[27]   Gaboon, N.E., Mohamed, A.R., Elsayed, S.M., Zaki, O.K. and Elsayed, M.A. (2015) Structural Chromosomal Abnormalities in Couples with Recurrent Abortion in Egypt. Turkish Journal of Medical Sciences, 45, 208-213.