IJMPCERO  Vol.7 No.2 , May 2018
Influence of Distinct Radiotherapy Techniques to Induce Second Cancer Risks in Left Breast Cancer
Abstract: Influence of distinct radiotherapy techniques to induce second cancer risks in left breast cancer. Material and methods: Ten female patients with intact left breast cancer. Two treatment plans for each patient: 1) two tangential beams 3D-Conformal radiotherapy, 2) intensity-modulated radiotherapy (IMRT) plan. Estimation of second cancer risk from Organ equivalent dose models (OEDs) in three dose-response model for organs at risk in left breast cases. Results: The P-value for OED models in 3D-IMRT for left lung, both lung, heart, right lung, right breast, thyroid, liver and spinal cord in linear dose model was 0.016, 0.005, 0.019, 3.95E-06, 5.79E-07, 0.003, 1.78E-10 and 0.000206475 respectively, for linear exponential dose model 0.0577, 0.024, 0.031, 3.40E-06, 3.28E-07, 0.003, 2.01E-10 and 0.000120072 respectively and in plateau dose model 0.088, 0.042, 0.039, 3.18E-06, 2.53E-07, 0.003, 2.27E-10 and 9.00535E-05 respectively. Conclusion: organ equivalent dose models for organs at risk increasing in IMRT than tangential beams.
Cite this paper: Elgendy, R. , Attia, W. , Attalla, E. and Elnaggar, M. (2018) Influence of Distinct Radiotherapy Techniques to Induce Second Cancer Risks in Left Breast Cancer. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 7, 193-202. doi: 10.4236/ijmpcero.2018.72017.

[1]   DeSantis, C., Ma, J., Bryan, L., et al. (2014) Breast Cancer Statistics. CA: A Cancer Journal for Clinicians, 64, 52-62.

[2]   Freedman, A.N., Yu, B., Gail, M.H., et al. (2011) Benefit/Risk Assessment for Breast Cancer Chemoprevention with Raloxifene or Tamoxifen for Women Age 50 Years or Older. Journal of Clinical Oncology, 29, 2327-2333.

[3]   Cordeiro, P.G. (2008) Breast Reconstruction after Surgery for Breast Cancer. The New England Journal of Medicine, 359, 1590-1601.

[4]   Zhang, P., Li, C.Z., Wu, C.T., Jiao, G.M., Yan, F., Zhu, H.C. and Zhang, X.-P. (2017) Comparison of Immediate Breast Reconstruction after Mastectomy and Mastectomy Alone for Breast Cancer: A Meta-Analysis. European Journal of Surgical Oncology, 43, 285-293.

[5]   Cahan, W.G., Woodard, H.Q., Higinbotham, L., Stewart, F.W. and Coley, B.L. (1948) Sarcoma Arising in Irradiated Bone: Report of Eleven Cases. Cancer, 1, 3-29.<3::AID-CNCR2820010103>3.0.CO;2-7

[6]   Suit, H., Goldberg, S., Niemierko, A., et al. (2007) Secondary Carcinogenesis in Patients Treated with Radiation: A Review on radiation-Induced Cancers in Human, Non-Human Primate, Canine and Rodent Subjects. Radiation Research, 167, 12-42.

[7]   Xu, X.G., Bernarz, B. and Paganetti, H. (2008) A Review of Dosimetry Studies on External-Beam Radiation Treatment with Respect to Second Cancer Induction. Physics in Medicine & Biology, 53, R193-R241.

[8]   Tubiana, M. (2009) Can We Reduce the Incidence of Second Primary Malignancies Occurring after Radiotherapy: A Critical Review. Radiotherapy & Oncology, 91, 4-15.

[9]   Shilkrut, M., Belkacemi, Y. and Kuten, A. (2012) Secondary Malignancies in Survivors of Breast Cancer: How to Overcome the Risk. Critical Reviews in Oncology/Hematology, 84, 86-89.

[10]   Woo, T.C., Pignol, J.P., Rakovitch, E., et al. (2006) Body Radiation Exposure in Breast Cancer Radiotherapy: Impact of Breast IMRT and Virtual Wedge Compensation Techniques. International Journal of Radiation Oncology, Biology, Physics, 65, 52-58.

[11]   Sachs, R.K., Brener, D.J., et al. (2005) Solid Tumor Risks after High Doses of Ionizing Radiation. Proceedings of the National Academy of Sciences of the United States of America, 102, 13040-13045.

[12]   Sakthivela, V., Mania, G., Mani, S. and Boopathy, R. (2017) Comparison of Treatment Planning Techniques in Treatment of Carcinoma of Left Breast: Second Cancer Perspective. Radiation Physics and Chemistry, 132, 41-45.

[13]   Schneider, U., Zwahlen, D., Ross, D., et al. (2005) Estimation of Radiation Induced Cancer from Three Dimensional Dose Distributions: Concept of Organ Equivalent Dose. International Journal of Radiation Oncology, Biology, Physics, 61, 1510-1515.

[14]   Rudat, V., Alaradi, A., Mohamed, A., AI-Yahya, K. and Altuwaijri, S. (2011) Tangential Beam IMRT versus Tangential Beam 3D-CRT of the Chest Wall in Post Mastectomy Breast Cancer Patients: A Dosimetric Comparison. Radiotherapy & Oncology, 6, 26.

[15]   Schneider, U., Walsh, L., et al. (2008) Cancer Risk Estimates from the Combined Japanese A-Bomb and Hodgkins Cohorts for Doses Relevant to Radiotherapy. Radiation and Environmental Biophysics, 47, 253-263.

[16]   Kim, D., Chung, W., Shin, D., Hong, Park, S.H., Park, S.Y., Chung, K., Lim, Y.K., Shin, D., Lee, S.B., Lee, H.H. and Yoon, M. (2013) Risk of Second Cancer from Scattered Radiation of Intensity-Modulated Radiotherapies with Lung Cancer. Radiation Oncology, 8, 47.

[17]   Zablotska, L.B. and Neugut, A.I. (2003) Lung Carcinoma after Radiation Therapy in Women Treated with Lumpectomy or Mastectomy for Primary Breast Carcinoma. Cancer, 97, 1404-1411.

[18]   Prochazka, M., Granath, F., Ekbom, A., Shields, P.G. and Hall, P. (2002) Lung Cancer risks in Women with Previous Breast Cancer. European Journal of Cancer, 38, 1520-1525.

[19]   Galper, S., Gelman, R., Recht, A., Silver, B., Kohli, A., Wong, J.S., Van Buren, T., Baldini, E.H. and Harris, J.R. (2002) Second Nonbreast Malignancies after Conservative Surgery and Radiation Therapy for Early-Stage Breast Cancer. International Journal of Radiation Oncology, Biology, Physics, 52, 406-414.

[20]   Fisher, B., Anderson, S., Bryant, J., Margolese, R.G., Deutsch, M., Fisher, E.R., Jeong, J.H. and Wolmark, N. (2002) Twenty-Year Follow-Up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer. The New England Journal of Medicine, 347, 1233-1241.

[21]   Roychoudhuri, R., Evans, H., Robinson, D. and Moller, H. (2004) Radiation-Induced Malignancies Following Radiotherapy for Breast Cancer. British Journal of Cancer, 91, 868-872.

[22]   van Dongen, J.A., Voogd, A.C., Fentiman, I.S., Legrand, C., Sylvester, R.J., Tong, D., van der Schueren, E., Helle, P.A., van Zijl, K. and Bartelink, H. (2000) Long-Term Results of a Randomized Trial Comparing Breast-Conserving Therapy with Mastectomy: European Organization for Research and Treatment of Cancer 10801 Trial. Journal of the National Cancer Institute, 92, 1143-1150.

[23]   Blichert-Toft, M., Nielsen, M., During, M., Moller, S., Rank, F., Overgaard, M. and Mouridsen, H.T. (2008) Long-Term Results of Breast Conserving Surgery vs. Mastectomy for Early Stage Invasive Breast Cancer: 20-Year Follow-Up of the Danish Randomized DBCG-82TM Protocol. Acta Oncologica, 47, 672-681.

[24]   Hall, E.J. and Wuu, C.S. (2003) Radiation-Induced Second Cancers: The Impact of 3D-CRT and IMRT. International Journal of Radiation Oncology, Biology, Physics, 56, 83-88.

[25]   Chaturvedi, A.K., Ahamad, A.A., Iyer, R.B., et al. (2007) Feasibility of Dose Escalation Using Intensity Modulated Radiotherapy in Posthysterectomy Cervical Carcinoma. Journal of the National Cancer Institute, 99, 1634-1643.

[26]   Boice, J.D., Day, N.E., Anderson, A., et al. (1985) Second Cancers Following Radiation Treatment for Cervical Cancer. Journal of the National Cancer Institute, 74, 955-959.