JBM  Vol.6 No.5 , May 2018
Atypical Polypoid Adenomyomas of Uterus: A Clinicopathologic Study of 2 Cases
Atypical polypoid Adenomyomas (APA) is a rare benign tumour in uterine. It is would distinguished from well-differentiated endometrial adenocarcinoma because of his histological features. We report 2 cases of 31-year-old and 33-year-old patient whose symptom were abnormal uterine bleeding. The mass was pedunculated with a narrow pedicle connecting to the pedunculated with a narrow pedicle connecting to the cervical; the other was in the uterine prolapse without pedicle. The surgical procedure was polypectomy only in all two patients with hysteroscopy. The histopathology showed the lesions were composed of a proliferation of irregular atypical endometrial glands separated by varying amounts of cellular smooth-muscle stroma. No mitotic activity was observed in the epithelial or mesenchymal elements in APA. The treatment of APA should depend on the age and reproductive desire of patient.
Cite this paper: Lin, X. and Li, Y. (2018) Atypical Polypoid Adenomyomas of Uterus: A Clinicopathologic Study of 2 Cases. Journal of Biosciences and Medicines, 6, 15-22. doi: 10.4236/jbm.2018.65003.

[1]   Mazur, M.T. (1981) Atypical Polypoid Adenomyomas of the Endometrium. Am J Surg Pathol, 5, 473-482.

[2]   Longacre, T.A., Chung, M.H., Rouse, R.V., et al. (1996) Atypical Polypoid Adenomyofibromas (Atypical Polypoid Adenomyomas) of the Uterus. A Clincopathologic Study of 55 Cases. Am J Surg Pathol, 20, 1-20.

[3]   Bisceglia, M. (2002) Atypical Polypoid Adenomyoma. Adv Anat Pathol, 9, 256-260.

[4]   Horn, L.C., Fischer, U. and Hockel, M. (2002) Polypoid Endometrial Adenomyoma in a Postmenopausal Woman, Mimicking Cervical Cancer, Associated with Ovarian the Coma. Areh Gynecol Obstet, 267, 101-103.

[5]   Zhou, Q., Ren, Y.Y. and Hou, W.L. (2013) Clinical Pathological Analysis of Endometrium Atypical Polyiform Adenomyoma. Medical Journal of Wuhan University, 34, 552-554.

[6]   Fukuda, M., Sakura, I.N., Yamamoto, Y., Taoka, H., Asakawa, Y., Kurasaki, A., et al. (2011) Case of Atypical Polypoid Adenomyma That Possibly Underwent a Serial Progression from Endometrial Hyperplasia to Carcinoma. J Obstet Gynaecol Res, 37, 468-471.

[7]   Di Palma, S., Santini, D. and Martinelli, G. (1989) Atypical Polypoid Adenomyoma of the Uterus. An Immunohistochemical Study of a Case. Tumori, 75, 295.

[8]   Ohishi, Y., Kaku, T., Kobayashi, H., et al. (2008) CD10 Immunostaining Distinguishes Atypical Poly-poid Adenomyofibroma (Atypical Polypoid Adenomyoma) from Endometrial Carcinoma Invading the Myometrium. Hum Pathol, 39, 1446-1453.

[9]   Horita, A., Kurata, A., Maeda, D., et al. (2011) Immunohistochemical Characteristics of Atypical Poly-poid Sdenoma with Special Reference to h-Caldesmon. Int J Gynecol Pathol, 30, 64-70.

[10]   Dobashi, Y., Fiedler, P.N. and Carcangiu, M.L. (1992) Polypoid Cystic Adenomyosis of the Uterus: Report of a Case. Int J Gynecol Pathol, 11, 240-243.

[11]   Payne, F., Rollason, T.P. and Sirridis, E. (1992) Adenomyolipoma of the Endometrium—A Hamartoma? Histopathology, 20, 357-359.

[12]   Sink Te, P., Miller, D.S., Milchgrub, S. and Hameed, A. (2000) Adenomyofibroma of the Endometrium with Skeletal Muscle Differentiation. Int J Gynecol Pathol, 19, 280-283.

[13]   Fedele, L., Bianchi, S., Zanotti, F., Marchini, M. and Candiani, G.B. (1993) Fertility after Conservative Surgery for Adenomyomas. Hum Reprod, 8, 1708-1710.

[14]   Heatley, M.K. (2006) Atypical Polypoid Sdenomyoma: A Systematic Review of the English Literature. Histopathology, 48, 609-610.

[15]   Maurizio, G., Greco, E., Di Spiezio Sardo, A., Di Carlo, C., Lavitola, G., Tarsitano, F., et al. (2008) Successful Pregnancy after Four-Step Hysteroscopic Technique for the Treatment of Atypical Polypoid Adenomyoma. Fertil Steril, 89, 1283-1284.