Back
 OJBIPHY  Vol.8 No.2 , April 2018
Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin)
Abstract: Pickering emulsions are systems without surfactants, stabilized by solid particles. These emulsions are experiencing a renewed interest, on the one hand, because it is preferable to limit the use of synthetic surfactants for toxicological and environmental reasons and, on the other hand, the need to make new formulations in order to control the drug release patterns by encapsulation or controlled release. Thus, we were interested in the formulation and evaluation of W/O Pickering emulsions stabilized by particles of magnesium oxide with paracetamol in the internal phase and griseofulvin in the external phase. The Bancroft rule served as a model for the formulation. The emulsification was carried out by progressively adding an aqueous phase dispersed in an oil-dispersing phase using a turbo rotor stator mixer. The stability of these emulsions was studied using several parameters (droplet size, pH, viscosity, conductivity ...) and the qualitative and quantitative analysis of the active ingredients by UV-visible spectrophotometry. The results obtained showed that the dye test and the conductivity measurement confirmed the W/O nature of these emulsions. Some parameters such as droplet size, pH and viscosity were strongly influenced by the amounts of magnesium oxide particles and the two active ingredients used. The qualitative and quantitative analysis of the active ingredients confirmed the presence of griseofulvin in the oil phase and paracetamol in the aqueous phase. Thus, we have succeeded in developing a stable W/O Pickering emulsion with magnesium oxide particles. In addition, we were able to incorporate paracetamol into the dispersed phase and griseofulvin into the dispersing phase of the emulsion.
Cite this paper: Sy, P. , Djiboune, A. , Diouf, L. , Soumboundou, M. , Ndong, B. , Ndiaye, A. , Dieng, S. , Diop, O. , Bathily, E. , Mbaye, G. , Faye, M. , Mbodj, M. and Diarra, M. (2018) Water/Oil Pickering Emulsion Stabilized by Magnesium Oxide Particles: A Potential System with Two Active Substances (Paracetamol and Griseofulvin). Open Journal of Biophysics, 8, 68-84. doi: 10.4236/ojbiphy.2018.82006.
References

[1]   Ramsden, W. (1903) The Separation of Solid Materials on the Surface of Solutions and Suspensions. Observation Concerning Surface Diagrams, Foam Blisters, Emulsions and Mechanical Coagulation. Proceedings of the Royal Society, 72, 156-164.
https://doi.org/10.1098/rspl.1903.0034

[2]   Pickering, S. (1907) Emulsions. Journal of Chemical Society, 91, 2001-2021.
https://doi.org/10.1039/CT9079102001
Frelichowska, J. (2009) Emulsions stabilisées par des particules solides: Etudes physico-chimiques et évaluation pour l’application cutanée. Lyon University, Lyon.

[3]   Chevalier Y.B.M. (2013) Emulsions Stabilized with Solid Nanoparticles: Pickering Emulsions. Colloids and Surface A: Physicochemical and Engineering Aspects, 439, 23-34.
https://doi.org/10.1016/j.colsurfa.2013.02.054

[4]   Frélichowska, J. (2009) émulsions stabilisées par des particules solides: Etudes physico-chimiques et évaluation pour l’application cutanée. Thèse de doctorat Université Claude Bernard Lyon 1, n°009, 211 p.

[5]   Arditty, S. (2004) Materials Based on Solid-Stabilized Emulsion. Journal of Colloid Interface Science, 275, 659-664.
https://doi.org/10.1016/j.jcis.2004.03.001

[6]   Fouilloux, S. (2011) Nanoparticules et microfluides pour un système modèle d’émulsions de Pickering. Etude des mécanismes de stabilisation et destabilisation. Pierre et Marie Curie University, Paris.

[7]   Aveyard, R.B.B. (2003) Emulsions Stabilized Solely by Colloidal Particles. Advances in Colloid and Interface Science, 100, 503-546.
https://doi.org/10.1016/S0001-8686(02)00069-6

[8]   Levine, S.S.E. (1985) Stabilisation of Emulsion Droplets by Fine Powders. Canadian Journal of Chemical Engineering, 62, 258-268.
https://doi.org/10.1002/cjce.5450630211

[9]   Abend, S.L.G. (2001) Bentonites and Double Hydroxides as Emulsifying Agents. Clay Minerals, 36, 557-570.
https://doi.org/10.1180/0009855013640009

[10]   Ashby, N.P.B.B. (2000) Pickering Emulsions Stabilised by Laponite Clay Particles. Physical Chemistry, 2, 5640-5646.
https://doi.org/10.1039/b007098j

[11]   Sharma, G.R.S. (2017) Phytoassisted Synthesis of Magnesium Oxide Nanoparticles by Swerta chirayaita. Journal of Taibah University for Sciences, 11, 471-477.
https://doi.org/10.1016/j.jtusci.2016.09.004

[12]   Frelichowska, J.B.M. (2010) Effect of Solid Particles Content on Properties of O/W Pickering Emulsions. Journal of Colloid and Interface Science, 351, 348-356.
https://doi.org/10.1016/j.jcis.2010.08.019

[13]   Yan, N.X.C.M. (2001) On Water-in-Oil Emulsions Stabilized by Solids. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 193, 97-107.
https://doi.org/10.1016/S0927-7757(01)00748-8

[14]   Yang, F.N.Q. (2007) Effect of Dispersion pH on the Formation and Stability of Pickering Emulsions Stabilized by Layered Double Hydroxides Particles. Journal of Colloid and Interface Science, 306, 285-295.
https://doi.org/10.1016/j.jcis.2006.10.062

[15]   Kim, J.H., K.S. (2004) Effect of Aqueous Phase Composition on the Stability of a Silica-Stabilized Water-in-Oil Emulsion. Ph.D. Cosmetic R and D Center, LG Household and Healthcare Research Park, 343-350.

[16]   Dorobantu, L.S., Y.A. (2004) Stabilization of Oil-Water Emulsions by Hydrophobic Bacteria. Applied and Environmental Microbiology, 70, 6333-6336.
https://doi.org/10.1128/AEM.70.10.6333-6336.2004

[17]   Tarimala, S., D.L. (2004) Structure of Microparticles in Solid Stabilized Emulsions. Langmuir, 20, 3492-3494.
https://doi.org/10.1021/la036129e

[18]   Leunissen, M.E., V.B. (2007) Electrostatics at the Oil Water Interface, Stability and Order in Emulsions and Colloids. Proceedings of the National Academy of Sciences, 104, 2585-2590.
https://doi.org/10.1073/pnas.0610589104

[19]   Torres, L., I.R. (2008) Pickering Emulsion Formation Aid the Removal of Creosote DNAPL from Porous Media? Chemosphere, 71, 123-132.
https://doi.org/10.1016/j.chemosphere.2007.09.053

[20]   Schaffazick, S., G.S. (2003) Physicochemical Characterization and Stability of the Polymeric Nanoparticle Systems for Drug Administration. Quimina Nova, 26, 726-737.
https://doi.org/10.1590/S0100-40422003000500017

 
 
Top