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 OJBIPHY  Vol.8 No.2 , April 2018
Role of Electrical Forces in Angiogenesis
Abstract: The role of electrical forces in angiogenesis is widely studied. The electric field (EF) induces polarization of the endothelial cells, and in this way, it is a morphogen in angiogenesis. Additional to the polarization, it may build up by newborn cells in the process of cellular fission. Due to the weak direct experimental results on the transitions of endothelial cells, we used an analogy to these epithelial transitions. This involved using the injury current, which induces oriented cell migration and morphological arrangement in wound healing. The injury-current considerations are applied for malignant proliferation as well.
Cite this paper: Szasz, O. , Szigeti, G. , Szasz, A. and Benyo, Z. (2018) Role of Electrical Forces in Angiogenesis. Open Journal of Biophysics, 8, 49-67. doi: 10.4236/ojbiphy.2018.82005.
References

[1]   Patan, S. (2004) Vasculogenesis and Angiogenesis. Cancer Treatment and Research, 117, 3-32.
https://doi.org/10.1007/978-1-4419-8871-3_1

[2]   Greaves, N.S., Ashcroft, K.J., Baguneid, M., et al. (2013) Current Understanding of Molecular and Cellular Mechanisms in Fibroplasia and Angiogenesis during Acute Wound Healing. Journal of Dermatological Science, 72, 206-217.
https://doi.org/10.1016/j.jdermsci.2013.07.008

[3]   Prior, B.M., Yang, H.T. and Terjung, R.L. (2004) What Makes Vessels Grow with Exercise Training? Journal of Applied Physiology, 97, 1119-1128.
https://doi.org/10.1152/japplphysiol.00035.2004

[4]   Adams, R.H. and Alitalo, K. (2007) Molecular Regulation of Angiogenesis and Lymphangiogenesis. Nature Reviews Molecular Cell Biology, 8, 464-478.
https://doi.org/10.1038/nrm2183

[5]   Algire, G.H. (1945) Vascular Reactions of Normal and Malignant Tissues in Vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants. Journal of the National Cancer Institute, 6, 73-85.
https://doi.org/10.1093/jnci/6.1.73

[6]   Hanahan, D. and Weinberg, R.A. (2000) The Hallmarks of Cancer. Cell, 100, 57-70.
https://doi.org/10.1016/S0092-8674(00)81683-9

[7]   Folkman, J. (1971) Tumor Angiogenesis: Therapeutic Implications. The New England Journal of Medicine, 285, 1182-1186.
https://doi.org/10.1056/NEJM197111182852108

[8]   Folkman, J. (1984) Angiogenesis. In: Jaffe, E.A., Ed., Biology of Endothelial Cells, Nijhoff, Boston, 412-428.
https://doi.org/10.1007/978-1-4613-2825-4_42

[9]   Markwald, R.R., Fitzharris, T.P. and Smith, W.N. (1975) Structural Analysis of Endocardial Cytodifferentiation. Developmental Biology, 42, 160-180.
https://doi.org/10.1016/0012-1606(75)90321-8

[10]   Markwald, R.R., Fitzharris, T.P. and Manasek, F.J. (1977) Structural Development of Endocardial Cushions. The American Journal of Anatomy, 148, 85-119.
https://doi.org/10.1002/aja.1001480108

[11]   Zeisberg, E.M., Potenta, S., Xie, L., et al. (2007) Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma—Associated Fibroblasts. Cancer Research, 67, 10123-10128.
https://doi.org/10.1158/0008-5472.CAN-07-3127

[12]   Zeisberg, E.M., Tarnavski, O., Zeisberg, M., et al. (2007) Endothelial-to-Mesenchymal Transition Contributes to Cardiac Fibrosis. Nature Medicine, 13, 952-961.
https://doi.org/10.1038/nm1613

[13]   Kalluri, R. and Zeisberg, M. (2006) Fibroblasts in Cancer. Nature Reviews Cancer, 6, 392-401.
https://doi.org/10.1038/nrc1877

[14]   Gerhardt, H., Golding, M., Fruttiger, M., et al. (2003) VEGF Guides Angiogenic Sprouting Utilizing Endothelial Tip Cell Filopodia. The Journal of Cell Biology, 161, 1163-1177.
https://doi.org/10.1083/jcb.200302047

[15]   Armulik, A., Abramsson, A. and Betsholtz, C. (2005) Endothelial/Pericyte Interactions. Circulation Research, 97, 512-523.
https://doi.org/10.1161/01.RES.0000182903.16652.d7

[16]   Mancardi, D., Varetto, G., Bucci, E., et al. (2008) Fractal Parameters and Vascular Networks: Facts & Artifacts. Theoretical Biology and Medical Modelling, 5, 1-8.

[17]   Xu, J., Vilanova, G. and Gomez, H. (2016) A Mathematical Model Coupling Tumor Growth and Angiogenesis. PLoS ONE, 11, e0149422.
https://doi.org/10.1371/journal.pone.0149422

[18]   Potenta, S., Zeisberg, E. and Kalluri, R. (2008) The Role of Endothelial-to-Mesenchymal Transition in Cancer Progression. British Journal of Cancer, 99, 1375-1379.
https://doi.org/10.1038/sj.bjc.6604662

[19]   Batlle, E., Sancho, E., Franci, C., et al. (2000) The Transcription Factor Snail Is a Repressor of E-Cadherin Gene Expression in Epithelial Tumour Cells. Nature Cell Biology, 2, 84-89.
https://doi.org/10.1038/35000034

[20]   Cano, A., Perez-Moreno, M.A., Rodrigo, I., et al. (2000) The Transcription Factor Snail Controls Epithelial-Mesenchymal Transitions by Repressing E-Cadherin Expression. Nature Cell Biology, 2, 76-83.
https://doi.org/10.1038/35000025

[21]   Zavadil, J. and Bottinger, E.P. (2005) TGF-Beta and Epithelial-to-Mesenchymal Transitions. Oncogene, 24, 5764-5774.
https://doi.org/10.1038/sj.onc.1208927

[22]   Tse, J. and Kalluri, R. (2007) Mechanisms of Metastasis: Epithelial-to-Mesenchymal Transition and Contribution of Tumor Microenvironment. Journal of Cellular Biochemistry, 101, 816-829. https://doi.org/10.1002/jcb.21215

[23]   Kovacic, J.C., Mercader, N., Torres, M., et al. (2012) Epithelial-to-Mesenchymal and Endothelial-to-Mesenchymal Transition from Cardiovascular Development to Disease. Circulation, 125, 1795-1808.
https://doi.org/10.1161/CIRCULATIONAHA.111.040352

[24]   Gurzu, S., Turdean, S., Kovecsi, A., Contac, A.O., et al. (2015) Epithelial-Mesenchymal, Mesenchymal-Epithelial, and Endothelial-Mesenchymal Transitions in Malignant Tumors: An Update. World Journal of Clinical Cases, 3, 393-404.
https://doi.org/10.12998/wjcc.v3.i5.393

[25]   Piera-Velazquez, S., Zhaodong, L. and Jimenez, S.A. (2011) Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders. The American Journal of Pathology, 179, 1074-1081.
https://doi.org/10.1016/j.ajpath.2011.06.001

[26]   Bryant, D.M. and Mostov, K.E. (2008) From Cells to Organs: Building Polarized Tissue. Nature Reviews Molecular Cell Biology, 9, 887-901.
https://doi.org/10.1038/nrm2523

[27]   Cope, F.W. (1969) Nuclear Magnetic Resonance Evidence using D2O for Structured Water in Muscle and Brain. Biophysical Journal, 9, 303-319.
https://doi.org/10.1016/S0006-3495(69)86388-5

[28]   Hazlewood, C.F., Chang, D.C., Medina, D., et al. (1972) Distinction between the Preneoplastic and Neoplastic State of Murine Mammary Glands. Proceedings of the National Academy of Sciences, 69, 1478-1480.
https://doi.org/10.1073/pnas.69.6.1478

[29]   Damadian, R. (1971) Tumor Detection by Nuclear Magnetic Resonance. Science, 171, 1151-1153.
https://doi.org/10.1126/science.171.3976.1151

[30]   Thiery, J.P. and Sleeman, J.P. (2006) Complex Networks Orchestrate Epithelialmesenchymal Transitions. Nature Reviews Molecular Cell Biology, 7, 131-142.
https://doi.org/10.1038/nrm1835

[31]   Liang, X., Gomez, G.A. and Yap, A.S. (2015) Current Perspectives on Cadherin-Cytoskeleton Interactions and Dynamics. Dove Medical Press, 7, 11-24.

[32]   Tsai, J.H. and Yang, J. (2013) Epithelial-Mesenchymal Plasticity in Carcinoma Metastasis. Genes & Development, 27, 2192-2206.
https://doi.org/10.1101/gad.225334.113

[33]   Wai, L.T. and Weinber, R.A. (2013) The Epigenetics of Epithelial-Mesenchymal Plasticity in Cancer. Nature Medicine, 19, 1438-1449.
https://doi.org/10.1038/nm.3336

[34]   Wong, I.Y., Javaid, S., Wong, E.A., et al. (2014) Collective and Individual Migration Following the Epithelial-Mesenchymal Transition. Nature Materials, 13, 1063-1071.
https://doi.org/10.1038/nmat4062

[35]   Hegyi, G., Vincze, Gy. and Szasz, A. (2012) On the Dynamic Equilibrium in Homeostasis. Open Journal of Biophysics, 2, 64-71.
https://doi.org/10.4236/ojbiphy.2012.23009

[36]   Tyler (2015) Understanding Mesenchymal to Epithelial Cell Transition May Be Key for Neo-Growth Plates. Natural Height Growth.
http://www.naturalheightgrowth.com/2015/11/11/understanding
mesenchymalendothelialcelltransitionmaykeyneogrowthplates/


[37]   Thiery, J.P., Acloque, H., Huang, R.Y., et al. (2009) Epithelial-Mesenchymal Transitions in Development and Disease. Cell, 139, 871-890.
https://doi.org/10.1016/j.cell.2009.11.007

[38]   Hugo, H., Ackland, M.L., Blick, T., et al. (2007) Epithelial-Mesenchymal and Mesenchymal-Epithelial Transitions in Carcinoma Progression. Journal of Cellular Physiology, 213, 374-383.
https://doi.org/10.1002/jcp.21223

[39]   Szentgyorgyi, A. (1998) Electronic Biology and Cancer. Marcel Dekker, New York.

[40]   Szentgyorgyi, A. (1957) Bioenergetica. Academic Press, New York.

[41]   Buchner, R., Barthel, J. and Stauber, J. (1999) The Dielectric Relaxation of Water between 0 °C and 35 °C. Chemical Physics Letters, 306, 57-63.
https://doi.org/10.1016/S0009-2614(99)00455-8

[42]   Gascoyne, P.R., Pethig, R. and Szentgyorgyi, A. (1981) Water Structure-Dependent Charge Transport in Proteins (Protons/Electrons/Charge Transfer/Dielectric Dispersion). Proceedings of the National Academy of Sciences, 78, 261-265.

[43]   Szentgyorgyi, A. (1978) The Living State and Cancer. Marcel Dekker Inc., New York.

[44]   Szentgyorgyi, A. (1968) Bioelectronics: A Study on Cellular Regulations, Defense and Cancer. Acad. Press, New York, London.

[45]   Shiraishi, T., Verdone, J.E., Huang, J., et al. (2014) Glycolysis Is the Primary Bioenergetic Pathway for Cell Motility and Cytoskeletal Remodeling in Human Prostate and Breast Cancer Cells. Oncotarget, 6, 130-143.

[46]   Kurakin, A. (2009) Scale-Free Flow of Life: On the Biology, Economics, and Physics of the Cell. Theoretical Biology and Medical Modelling, 6, 6.

[47]   Hochachka, P.W. (1999) The Metabolic Implications of Intracellular Circulation. Proceedings of the National Academy of Sciences, 96, 12233-12239.
https://doi.org/10.1073/pnas.96.22.12233

[48]   Coulson, R.A. (1986) Metabolic Rate and the Flow Theory: A Study in Chemical Engineering. Comparative Biochemistry and Physiology Part A, 84, 217-229.
https://doi.org/10.1016/0300-9629(86)90607-9

[49]   Brown, M.F., Gratton, T.P. and Stuart, J.A. (2007) Metabolic Rate Does Not Scale with Body Mass in Cultured Mammalian Cells. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 292, 2115-2121.
https://doi.org/10.1152/ajpregu.00568.2006

[50]   Kleiber, M. (1947) Body Size and Metabolic Rate. Physiological Reviews, 27, 511-541.
https://doi.org/10.1152/physrev.1947.27.4.511

[51]   West, G.B., Brown, J.H. and Enquist, B.J. (1999) The Fourth Dimension of Life: Fractal Geometry and Allometric Scaling of Organisms. Science, 284, 1677-1679.
https://doi.org/10.1126/science.284.5420.1677

[52]   Bonner, J.T. (1967) The Cellular Slime Moulds. 2nd Edition, Princeton University Press, Princeton.

[53]   Martin-Belmonte, F. and Mostov, K. (2008) Regulation of Cell Polarity during Epithelial Morphogenesis. Current Opinion in Cell Biology, 20, 227-234.
https://doi.org/10.1016/j.ceb.2008.01.001

[54]   Yang, K.L., Huang, C.C., Chi, M.S., et al. (2016) In Vitro Comparison of Conventional Hyperthermia and Modulated Electro-Hyperthermia. Oncotarget, 7, 84082-84092.

[55]   Kim, E.H., Song, H.S., Seung S.H., et al. (2016) Tumor Treating Fields Inhibit Glioblastoma Cell Migration, Invasion and Angiogenesis. Oncotarget, 7, 65125-65136.

[56]   Becker, R.O. and Selden, G. (1985) The Body Electric. Morrow, New York.

[57]   Becker, R.O. (1990) Cross Currents. Jeremy P Tarcher Inc., Los Angeles.

[58]   McCaig, C.D., Rajnicek, A.M., Song, B., et al. (2005) Controlling Cell Behaviour Electrically: Current Views and Future Potential. Physiological Reviews, 85, 943-978.
https://doi.org/10.1152/physrev.00020.2004

[59]   Rosch, P.J. and Markov, M.S. (2004) Bioelectromagnetic Medicine. Marcell Decker Inc., New York.

[60]   Reid, B., McCaig, C.D., Zhao, M., et al. (2005) Wound Healing in Rat Cornea: The Role of Electric Currents. FASEB J, 19, 379-386.
https://doi.org/10.1096/fj.04-2325com

[61]   Barker, A.T., Jaffe, L.F. and Vanable, J.W. (1982) The Glabrous Epidermis of Cavies Contains a Powerful Battery. American Journal of Physiology, 242, 358-366.

[62]   Song, B., Zhao, M., Forrester, J., et al. (2004) Nerve Regeneration and Wound Healing Are Stimulated and Directed by an Endogenous Electrical Field in Vivo. Journal of Cell Science, 117, 4681-4690.
https://doi.org/10.1242/jcs.01341

[63]   Carbon, M., Wübbeler, G., Mackert, B.M., et al. (2004) Non-Invasive Magnetic Detection of Human Injury Currents. Clinical Neurophysiology, 115, 1027-1032.
https://doi.org/10.1016/j.clinph.2003.12.035

[64]   Reid, B., Nuccitelli, R. and Zhao, M. (2007) Non-Invasive Measurement of Bioelectric Currents with a Vibrating Probe. Nature Protocols, 2, 661-669.
https://doi.org/10.1038/nprot.2007.91

[65]   Mackert, B.M., Mackert, J., Wübbeler, G., et al. (1999) Magnetometry of Injury Currents from Human Nerve and Muscle Specimens using Superconducting Quantum Interferences Devices. Neuroscience Letters, 262, 163-166.
https://doi.org/10.1016/S0304-3940(99)00067-1

[66]   Song, B., Zhao, M., Forrester, J.V., et al. (2002) Electrical Cues Regulate the Orientation and Frequency of Cell Division and the Rate of Wound Healing in Vivo. PNAS, 99, 13577-13582.
https://doi.org/10.1073/pnas.202235299

[67]   Zhao, M. (2009) Electrical Fields in Wound Healing—An Overriding Signal That Directs Cell Migration. Seminars in Cell and Developmental Biology, 20, 674-682.
https://doi.org/10.1016/j.semcdb.2008.12.009

[68]   Buck, R.C. (1985) Measurement of Centripetal Migration of Normal Corneal Epithelial Cells in the Mouse. Investigative Ophthalmology & Visual Science, 26, 1296-1299.

[69]   Adler, P.M. (1992) Porous Media Geometry and Transport. Butterworth-Heinemann, Boston, London, Oxford.

[70]   Zhao, M., Forrester, J.V. and McCaig, C.D. (1999) A Small, Physiological Electric Field Orients Cell Division. Proceedings of the National Academy of Sciences, 96, 4942-4946.

[71]   Mycielska, M.E. and Djamgoz, M.B.A. (2004) Cellular Mechanisms of Direct-Current Electric Field Effects: Galvanotaxis and Metastatic Disease. Journal of Cell Science, 117, 1631-1639.
https://doi.org/10.1242/jcs.01125

[72]   Pu, J., McCaig, C.D., Cao, L., et al. (2007) EGF Receptor Signalling Is Essential for Electric-Field-Directed Migration of Breast Cancer Cells. Journal of Cell Science, 120, 3395-3403.
https://doi.org/10.1242/jcs.002774

[73]   Meng, X. and Riordan, N.H. (2006) Cancer Is a Functional Repair Tissue. Medical Hypotheses, 66, 486-490.
https://doi.org/10.1016/j.mehy.2005.09.041

[74]   Nordenström, B.E.W. (1978) Preliminary Clinical Trials of Electrophoretic Ionization in the Treatment of Malignant Tumors. IRCS Medical Science, 6, 537-540.

[75]   Nordenström, B.E.W. (1985) Electrochemical Treatment of Cancer. Annales De Radiologie, 28, 128 129.

[76]   Nordenstrom, B.W.E. (1983) Biologically Closed Electric Circuits: Clinical Experimental and Theoretical Evidence for an Additional Circulatory System. Nordic Medical Publications, Stockholm.

[77]   Nordenstrom, B.W.E. (1998) Exploring BCEC-Systems, (Biologically Closed Electric Circuits). Nordic Medical Publications, Stockholm.

[78]   Watson, B.W. (1991) Reappraisal: The Treatment of Tumors with Direct Electric Current. Medical Science Research, 19, 103-105.

[79]   Samuelsson, L., Jonsson, L. and Stahl, E. (1983) Percutaneous Treatment of Pulmonary Tumors by Electrolysis. Radiologie, 23, 284-287.

[80]   Miklavcic, D., Sersa, G., Kryzanowski, M., et al. (1993) Tumor Treatment by Direct Electric Current, Tumor Temperature and pH, Electrode Materials and Configuration. Bioelectrochemistry and Bioenergetics, 30, 209-220.
https://doi.org/10.1016/0302-4598(93)80080-E

[81]   Ud-Din, S., Sebastian, A., Giddings, P., et al. (2015) Angiogenesis Is Induced and Wound Size Is Reduced by Electrical Stimulation in an Acute Wound Healing Model in Human Skin. PLoS ONE, 10, e0124502.
https://doi.org/10.1371/journal.pone.0124502

[82]   Loewenstein, W.R. and Kanno, Y. (1967) Intercellular Communication and Tissue Growth. The Journal of Cell Biology, 33, 225-234.
https://doi.org/10.1083/jcb.33.2.225

[83]   Loewenstein, W.R. (1999) The Touchstone of Life, Molecular Information, Cell Communication and the Foundations of the Life. Oxford University Press, Oxford, New York, 298-304.

[84]   James, A.M., Ambrose, E.J. and Lowick, J.H.B. (1956) Differences between the Electrical Charge Carried by Normal and Homologous Tumor Cells. Nature, 177, 576-577.
https://doi.org/10.1038/177576a0

[85]   Binggeli, R. and Weinstein, R.C. (1986) Membrane Potentials and Sodium Channels: Hypotheses for Growth Regulation and Cancer Formation Based on Changes in Sodium Channels and Gap Junctions. Journal of Theoretical Biology, 123, 377-401.
https://doi.org/10.1016/S0022-5193(86)80209-0

 
 
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