Giant cell tumor of the larynx (GCTL) is an uncommon entity with only 42 reported cases in the literature. GCTL is typically found in the epiphysis of the long bones of female patients in the third decade. In the head and neck area, it usually occurs in the sphenoid, temporal and ethmoid bones, and rarely presents larynx involvement  . The thyroid cartilage is the most frequently affected laryngeal structure (21.6%), followed by the cricoid cartilage (9.26%), the epiglottis (2.6%) and soft tissues of the larynx (2.6%)  .
2. Case Report
A 57-year-old man was referred to the hospital for evaluation of hoarseness and a growing anterior neck mass for the past 5 months. The patient had no smoking history and no prior occupational exposure. The physical examination showed a painless, indurated mass, adherent to deep planes in the left anterior portion of the neck. A nasopharyngolaryngoscopy was performed and revealed a submucosal swelling of the left supraglottic area.
A contrast-enhanced CT (Figure 1(A)) and a coronal FSE T2-weighted MRI (Figure 1(B)) showed a large, hyper-intense and expansive mass in the left thyroid cartilage lamina, with radiological signs of low aggressiveness. The mass surpassed laryngeal midline and presented no invasion of the strap muscles or surrounding soft tissue.
A fine needle aspiration cytology (FNAC) of the anterior neck mass was performed. Cytopathological analysis showed mesenchymal cells in contact with osteoclastic-type multinucleated giant cells. A giant cell tumor of the larynx was suspected.
The case was discussed in a Head and Neck Cancer interdisciplinary committee. Supracricoid subtotal laryngectomy was proposed and performed. The pathology analysis showed a giant cell tumor of the left thyroid cartilage. Macroscopy revealed a homogenous nodular mass with central hemorrhagic focus. Microscopy showed a cellular neoplasm with numerous uniformly distributed osteoclastic-type giant cells separated by mononuclear cells in a vascular stroma (Figure 2).
The patient started speech and swallowing rehabilitation a week after surgery
Figure 1. A contrast-enhanced CT (A) and a coronal FSE T2-weighted MRI (B) showed a large, hyper-intense and expansive mass in the left thyroid cartilage lamina.
Figure 2. Multinucleated giant cells (A), osteoclastic-type giant cells separated by mononuclear cells in a vascular stroma (B). Histological (C) and macroscopy (D) correlation of an expansive giant cell tumor in the left thyroid cartilage.
and achieved normal laryngeal function two months later, speaking and eating normally. No evidence of recurrence or metastasis was observed at a ten month follow-up.
Giant cell tumor of the larynx is an uncommon entity with 42 cases reported in the literature, of which 32 involved the thyroid cartilage  . This tumor is usually benign but can be locally aggressive, recur (25% of cases), and occasionally produce pulmonary metastasis   .
GCTL should be included in the differential diagnosis of a patient with hoarseness and anterior neck swelling. The differential diagnosis of a mass in the thyroid cartilage area includes diseases like chondroblastoma, chondrosarcoma, osteoblastoma, giant cell-rich osteosarcoma, foreign body reaction, brown tumor of hyperparathyroidism or GCTL   . Imaging studies are not usually sufficient to differentiate these entities, so it is imperative to perform histological examination in order to reach a diagnosis  .
A mixture of multinucleated giant cells and mononuclear cells in fibroblastic rich, loose, hemorrhagic, vascular stroma is typical of GCTL  . Giant cell nuclei are strikingly similar to mononuclear cells. In giant cell tumors the mononuclear component expresses alkaline phosphatase, receptor activator of nuclear factor kappa-B ligated (RANKL) and markers of osteoblast lineage  .
There is no consensus regarding the management, although surgical excision, ranging from local excision to total laryngectomy is the most frequently employed treatment with excellent outcomes. Other treatments employed were radiation with or without chemotherapy, and systemic denosumab (a monoclonal antibody against the RANK ligand)  .
Giant cell tumor of the larynx is an uncommon entity, with very few cases reported in the literature. There is no consensus regarding the management, although surgical excision is the most frequently employed treatment. These tumors should be included in the differential diagnosis of a patient with hoarseness and anterior neck swelling.
Conflict of Interest
No potential conflicts of interest have to be disclaimed. Informed consent was obtained from the patient for publication of this case report and any accompanying images.
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