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 JBM  Vol.6 No.1 , January 2018
Clinical Characteristics of Vaginal Discharge Associated Streptococcus pyogenes at General Japanese Hospital
Abstract:
Streptococcus pyogenes (S. pyogenes) is popular pathogen caused various infectious disease. This study was conducted to find out the recent clinical characteristics of S. pyogenes isolates from vaginal discharge at Japanese hospital. S. pyogenes was identified by standard laboratory procedure. Antimicrobial susceptibility testing was performed by microdilution assay according to CLSI recommendation. Total 61 S. pyogenes were isolated from vaginal discharge. The major age incidence among 0 - 10 years age group was 14 (23%), among 21 - 30 years age group, 7 (11.5%), among 31 - 40 years age group, 13 (21.3%), among 51 - 60 years age group, 8 (13.1%), and among 61 - 70 years age group, 11 (18%). The numbers of ciprofloxacin and clarithromycin no-susceptible S. pyogenes from 0 - 10, 31 - 40, and 61-70 years age group were higher than those from other groups. The numbers of clindamycin and minocycline no susceptible S. pyogenes from 0 - 10, and 21 - 40 years age group were higher than those from other group. Furthermore, our study revealed that clarithromycin was completely ineffective in 21 - 30 years age group (p < 0.05). As the numbers of under and not less than 13 year age group were 15, and 46, respectively, the number of adult cases was higher than the number of child cases. Clarithromycin no-susceptible rate was highest and minocycline no-susceptible rate was lowest in both group. There was no significant difference of antimicrobial susceptible trends between under and not less than 13 year age groups. Our study suggests the need for continuous epidemiological surveillance of vaginal discharge associated S. pyogenes because the trend of infectious disease epidemiology is always changing drastically.
Cite this paper: Minami, M. , Sakakibara, R. , Watanabe, M. , Morita, H. , Kanemaki, N. and Ohta, M. (2018) Clinical Characteristics of Vaginal Discharge Associated Streptococcus pyogenes at General Japanese Hospital. Journal of Biosciences and Medicines, 6, 9-16. doi: 10.4236/jbm.2018.61002.
References

[1]   Eschenbach, D.A., Hillier, S., Critchlow, C., Stevens, C., DeRouen, T. and Holmes, K.K. (1988) Diagnosis and Clinical Manifestations of Bacterial Vaginosis. Am J Obstet Gynecol, 158, 819-828. https://doi.org/10.1016/0002-9378(88)90078-6

[2]   Koumans, E.H., Sternberg, M., Bruce, C., McQuillan, G., Kendrick, J., Sutton, M., et al. (2007) The Prevalence of Bacterial Vaginosis in the United States, 2001-2004; Associations with Symptoms, Sexual Behaviors, and Reproductive Health. Sex Transm Dis, 34, 864-869. https://doi.org/10.1097/OLQ.0b013e318074e565

[3]   Mitchell, C. and Marrazzo, J. (2014) Bacterial Vaginosis and the Cervicovagi-nal Immune Response. Am J Reprod Immunol, 71, 555-563. https://doi.org/10.1111/aji.12264

[4]   Muzny, C.A. and Schwebke, J.R. (2016) Pathogenesis of Bacterial Vaginosis: Discussion of Current Hypotheses. J Infect Dis, 214, S1-S5. https://doi.org/10.1093/infdis/jiw121

[5]   Eschenbach, D.A. (1993) Bacterial Vaginosis and Anaerobes in Obstetric-Gynecologic Infection. Clin Infect Dis, 16, S282-S287. https://doi.org/10.1093/clinids/16.Supplement_4.S282

[6]   Hillier, S.L., Nugent, R.P., Eschenbach, D.A., Krohn, M.A., Gibbs, R.S., Martin, D.H., et al. (1995) Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med, 333, 1737-1742. https://doi.org/10.1056/NEJM199512283332604

[7]   Cunningham, M.W. (2000) Pathogenesis of Group A Streptococcal Infections. Clin Microbiol Rev, 13, 470-511. https://doi.org/10.1128/CMR.13.3.470-511.2000

[8]   Hikone, M., Kobayashi, K., Washino, T., Ota, M., Sakamoto, N., Iwabuchi, S., et al. (2015) Streptococcal Toxic Shock Syndrome Secondary to Group A Streptococcus Vaginitis. J Infect Chemother, 12, 873-876. https://doi.org/10.1016/j.jiac.2015.07.011

[9]   Mead, P.B. and Winn, W.C. (2000) Vaginal-Rectal Colonization with Group A Streptococci in Late Pregnancy. Infect Dis Obstet Gynecol, 8, 217-219. https://doi.org/10.1155/S1064744900000302

[10]   Clinical and Laboratory Standards Institute (CLSI) (2014) Performance Standards for Antimicrobial Susceptibility Testing: 24th Informational Supplement, Clinical and Laboratory Standards Institute M100-S24, Wayne.

[11]   Goto, H., Shimada, K., Ikemoto, H., Oguri, T., Study Group on Antimicrobial Susceptibility of Pathogens Isolated from Respiratory Infections (2009) Antimicrobial Susceptibility of Pathogens Isolated from More than 10,000 Patients with Infectious Respiratory Diseases: A 25-Year Longitudinal Study. J Infect Chemother, 15, 347-360. https://doi.org/10.1007/s10156-009-0719-3

[12]   Cervin, A. and Wallwork, B. (2007) Macrolide Therapy of Chronic Rhinosinusitis. Rhinology, 45, 259-267.

[13]   Kudoh, S. and Keicho, N. (2012) Diffuse Panbronchiolitis. Clin Chest Med, 33, 297-305. https://doi.org/10.1016/j.ccm.2012.02.005

[14]   Stricker, T., Navratil, F. and Sennhauser, F.H. (2003) Vulvovaginitis in Prepubertal Girls. Arch Dis Child, 88, 324-326. https://doi.org/10.1136/adc.88.4.324

[15]   Randjelovic, G., Otasevic, S., Mladenovic-Antic, S., Mladenovic, V., Radovanovic-Velickovic, R., Randjelovic, M., et al. (2017) Streptococcus pyogenes as the Cause of Vulvovaginitis and Balanitis in Children. Pediatr Int, 59, 432-437. https://doi.org/10.1111/ped.13169

 
 
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