JBM  Vol.5 No.12 , December 2017
Level of Macronutrients and Microelements of Blood Plasma in Different Forms of Pulmonary Tuberculosis
Abstract: By the method of atomic emission spectrometry with inductively coupled plasma, the content of macro and microelements in the blood plasma of 35 practically healthy people living in the Northern region of Azerbaijan and in the Nizhny Novgorod region of the Russian Federation was studied as well as of 23 patients with pulmonary tuberculosis with different phases of the disease. The elemental homeostasis of the blood plasma did not significantly differ depending on the region of residence, except for the potassium level (by 1.3 times greater for Russians) and strontium (by 10 times higher among the inhabitants of the Northern region of Azerbaijan). In patients with focal pulmonary tuberculosis, there were no significant differences in the content of elements in the blood plasma. With pulmonary tuberculosis, accompanied by decomposition processes, the content of calcium, copper, zinc and iron in blood plasma significantly increases in comparison with healthy people. Analysis of the level of these macro- and microelements can be used to determine the transition of the early form of pulmonary tuberculosis to infiltrative and/or cavernous forms, in which the patient becomes epidemiologically dangerous to others.
Cite this paper: Obukhova, L. , Erlykina, E. , Aliyev, A. , Chobanov, R. , Pimenov, V. , Evdokimov, I. and Sarvarov, A. (2017) Level of Macronutrients and Microelements of Blood Plasma in Different Forms of Pulmonary Tuberculosis. Journal of Biosciences and Medicines, 5, 81-87. doi: 10.4236/jbm.2017.512009.

[1]   Crofton, D., Khorn, N. and Miller, F. (2016) Clinic of Tuberculosis. Meditsina, Мoscow, 199. [in Russian]

[2]   Oberlis, D., Kharland, B. and Skalnyi, А. (2015) Biological Role of Macro- and Microelements in Humans and Animals. Nauka, Saint Petersburg, 544. [in Russian]

[3]   Mohan, G., Kulshreshtha, S. and Sharma, P. (2006) Zinc and Copper in Indian Patients of Tuberculosis: Impact on Antitubercular Therapy. Biological Trace Element Research, 111, 63-69.

[4]   Novitskii, V.V., Strelis, А.К., Urazova, О.I., Shil’ko, Т.А., Esimova, I.Е., Voronkova, О.V., Sinitsina, V.А., Filinyuk, О.V., Ivanova, Е.V., Baranova, О.V. and Tkachenko, S.B. (2016) Macro- and Microelements of Blood Mononuclear Cells in Patients with Pulmonary Tuberculosis. Mikroelementy v medicine, 7, 33-38. [in Russian]

[5]   Niizuma, H., Fujii, K., Sato, A., Fujiwara, I., Takeyama, J. and Imaizumi, M. (2007) PTHrP-Independent Hypercalcemia with Increased Proinflammatory Cytokines and Bone Resorption in Two Children with CD19-Negative Precursor B Acute Lymphoblastic Leukemia. Pediatric Blood & Cancer, 49, 990-993.

[6]   Gromova, О.А., Torshin, I.Y., Grishina, Т.R. and Lisitsa, А.V. (2013) Prospects for Using Preparations Based on Organic Calcium Salts. Molecular Mechanisms of Calcium. Lechashchii Vrach, 4, 42-44. [in Russian]

[7]   Zenkov, N.К., Lankin, V.Z. and Men’shchikova, Е.B. (2014) Oxidative Stress. Nauka, Мoscow, 343. [in Russian]

[8]   Publishing House М. (2015) All about Vitamins and Microelement. Praktika, Мoscow, 382. [in Russian]

[9]   Novikova, I.А. (2011) Iron and Immune Response. Problemy zdorov’ya i ekologii, 5, 42-48. [in Russian]

[10]   Skal’nyi, А.V. (2013) Zinc and Human Health. RIK GOUOGU, Orenburg, 80. [in Russian]

[11]   Kudrin, А.V. and Skal’nyi А.V. (2011) Microelements in Oncology. Part 2. Microelements and Antitumor Immunity. Mikroelementy v medicine, 2, 31-39. [in Russian]

[12]   Hosea, H.J., Rector, E.S. and Taylor, C.G. (2003) Zinc-Deficient Rats Have Fewer Recent Thymic Emigrant (CD90+) T Lymphocytes in Spleen and Blood. Journal of Nutrition, 133, 4239-4242.

[13]   Oppenheimer, S.J. (2001) Iron and Its Relation to Immunity and Infectious Disease. Journal of Nutrition, 131, 616-635.

[14]   Beard, J.L. (2001) Iron Biology in Immune Function, Muscle Metabolism and Neuronal Functioning. Journal of Nutrition, 131, 568-580.

[15]   Ahluwalia, N., Sun, J., Krause, D., Mastro, A. and Handte, G. (2004) Immune Function Is Impaired in Irondeficient, Homebound, Older Women. American Journal of Clinical Nutrition, 79, 516-521.

[16]   Bhaskaram, P. (2002) Micronutrient Malnutrition, Infection, and Immunity: Аn Overview. Nutrition Reviews, 60, 40-45.

[17]   Kumar, V. and Choudhry, V.P. (2010) Iron Deficiency and Infection. Indian Journal of Pediatrics, 77, 789-793.

[18]   Di Costanzo, L., Pique, M.E. and Christianson, D.W. (2007) Crystal Structure of Human Arginase I Complexed with Thiosemicarbazide Reveals an Unusual Thiocarbonly μ-Sulfide Ligand in the Binuclear Manganese Cluster. Journal of the American Chemical Society, 129, 6388-6389.

[19]   Locksley, R.M., Killeen, N. and Lenardo, M.J. (2001) The TNF and TNF Receptor Superfamilies: Integrating Mammalian Biology. Cell, 104, 487-501.

[20]   Irfan, A., Srivastava, V.K., Prasad, R., Mohd, Y., Safia, Saleem M. and Wahid, A. (2011) Deficiency of Micronutrient Status in Pulmonary Tuberculosis Patients in North India. Bio-medical Research, 22, 449-454.