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 JBM  Vol.5 No.11 , November 2017
Cardiovascular Risk Factors and Epicardial Adipose Tissue Measured by Chest Computed Tomography in Healthy Adults
Abstract: Background: Epicardial adipose tissue (EAT) may produce several cytokines contributed to coronary atherosclerosis. EAT was measured by transthoracic echocardiography or 3 dimensional cardiac computed tomography (CT) on previous studies. We aimed to evaluate the correlation between EAT thickness and cardiovascular risk factors in healthy adults. Method: We collected clinical, biochemical information from 469 subjects (371 men and 98 women) who visited our health promotion center. EAT thickness was measured by chest CT on the free wall of the right ventricle. Result: The mean EAT thickness was 2.47 ± 1.64 mm in total of 469 subjects. EAT thickness was significantly correlated to age, weight, body mass index (BMI), total body fat, systolic and diastolic blood pressure, total cholesterol, low density lipoprotein (LDL)-cholesterol, and fasting glucose in men and to age, height, weight, BMI, total body fat, systolic and diastolic blood pressure, triglycerides, C-reactive protein (CRP), and fasting glucose in women. Multivariate analysis showed that age, BMI, systolic blood pressure, fasting glucose were the variables that independently correlated to EAT thickness in men. But there was no significant independent variable in women. Conclusion: In our study, EAT thickness measured with chest CT in healthy individuals correlates with cardiovascular risk factors in men.
Cite this paper: Kim, J. and Lee, S. (2017) Cardiovascular Risk Factors and Epicardial Adipose Tissue Measured by Chest Computed Tomography in Healthy Adults. Journal of Biosciences and Medicines, 5, 41-50. doi: 10.4236/jbm.2017.511006.
References

[1]   Wilson, P.W., D’Agostino, R.B., Sullivan, L., Parise, H., Kannel Wilson, P.W., D'Agostino, R.B., Sullivan, L., Parise, H. and Kannel, W.B. (2002) Overweight and Obesity as Determinants of Cardiovascular Risk: The Framingham Experience. Archives of Internal Medicine, 162, 1867-1872.
https://doi.org/10.1001/archinte.162.16.1867

[2]   Albu, J.B., Kovera, A.J. and Johnson, J.A. (2000) Fat Distribution and Health in Obesity. Annals of the New York Academy of Sciences, 904, 491-501.
https://doi.org/10.1111/j.1749-6632.2000.tb06505.x

[3]   Molenaar, E.A., Hwang, S.J., Vasan, R.S., Grobbee, D.E., Meigs, J.B., D’Agostino, R.B., et al. (2008) Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity: The Framingham Heart Study. Diabetes Care, 31, 1367-1372.
https://doi.org/10.2337/dc07-2413

[4]   Shimabukuro, M. (2009) Cardiac Adiposity and Global Cardiometabolic Risk: New Concept and Clinical Implication. Circulation Journal, 73, 27-34.
https://doi.org/10.1253/circj.CJ-08-1012

[5]   Bjorntorp, P. (1990) “Portal” Adipose Tissue as a Generator of Risk Factors for Cardiovascular Disease and Diabetes. Arteriosclerosis, 10, 493-496.
https://doi.org/10.1161/01.ATV.10.4.493

[6]   Iacobellis, G., Assael, F., Ribaudo, M.C., Zappaterreno, A., Alessi, G., Di Mario, U., et al. (2003) Epicardial Fat from Echocardiography: A New Method for Visceral Adipose Tissue Prediction. Obesity, 11, 304-310.
https://doi.org/10.1038/oby.2003.45

[7]   Bertaso, A.G., Bertol, D., Duncan, B.B. and Foppa, M. (2013) Epicardial Fat: Definition, Measurements and Systematic Review of Main Outcomes. Arquivos Brasileiros De Cardiologia, 101, e18-e28.

[8]   Sarin, S., Wenger, C., Marwaha, A., Qureshi, A., Go, B.D., Woomert, C.A., et al. (2008) Clinical Significance of Epicardial Fat Measured Using Cardiac Multislice Computed Tomography. American Journal of Cardiology, 102, 767-771.
https://doi.org/10.1016/j.amjcard.2008.04.058

[9]   Meenakshi, K., Rajendran, M., Srikumar, S. and Chidambaram, S. (2016) Epicardial Fat Thickness: A Surrogate Marker of Coronary Artery Disease—Assessment by Echocardiography. Indian Heart Journal, 68, 336-341.
https://doi.org/10.1016/j.ihj.2015.08.005

[10]   Després, J.P., Lemieux, I. and Prud’homme, D. (2001) Treatment of Obesity: Need to Focus on High Risk Abdominally Obese Patients. BMJ, 322, 716-720.
https://doi.org/10.1136/bmj.322.7288.716

[11]   Després, J.P. (2006) Is Visceral Obesity the Cause of the Metabolic Syndrome? Annals of Medicine, 38, 52-63.
https://doi.org/10.1080/07853890500383895

[12]   Carr, D.B., Utzschneider, K.M., Hull, R.L., Kodama, K., Retzlaff, B.M., Brunzell, J.D., et al. (2004) Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome. Diabetes, 53, 2087-2094. https://doi.org/10.2337/diabetes.53.8.2087

[13]   Mazurek, T., Zhang, L., Zalewski, A., Mannion, J.D., Diehl, J.T., Arafat, H., et al. (2003) Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators. Circulation, 108, 2460-2466.
https://doi.org/10.1161/01.CIR.0000099542.57313.C5

[14]   Baker, A.R., Silva, N.F., Quinn, D.W., Harte, A.L., Pagano, D., Bonser, R.S., et al. (2006) Human Epicardial Adipose Tissue Expresses a Pathogenic Profile of Adipocytokines in Patients with Cardiovascular Disease. Cardiovascular Diabetology, 5, 1-8.
https://doi.org/10.1186/1475-2840-5-1

[15]   Yong, H.S., Kim, E.J., Seo, H.S., Kang, E.Y., Kim, Y.K., Woo, O.H., et al. (2010) Pericardial Fat Is More Abundant in Patients with Coronary Atherosclerosis and Even in the Non-Obese Patients: Evaluation with Cardiac CT Angiography. The International Journal of Cardiovascular Imaging, 26, 53-62.
https://doi.org/10.1007/s10554-009-9542-2

[16]   Jeong, J.W., Jeong, M.H., Yun, K.H., Oh, S.K., Park, E.M., Kim, Y.K., et al. (2007) Echocardiographic Epicardial Fat Thickness and Coronary Artery Disease. Circulation Journal, 71, 536-539.
https://doi.org/10.1253/circj.71.536

[17]   Ahn, S.G., Lim, H.S., Joe, D.Y., Kang, S.J., Choi, B.J., Choi, S.Y., et al. (2008) Relationship of Epicardial Adipose Tissue by Echocardiography to Coronary Artery Disease. Heart, 94, e7.
https://doi.org/10.1136/hrt.2007.118471

[18]   Iacobellis, G., Ribaudo, M.C., Assael, F., Vecci, E., Tiberti, C., Zappaterreno, A., et al. (2003) Echocardiographic Epicardial Adipose Tissue Is Related to Anthropometric and Clinical Parameters of Metabolic Syndrome: A New Indicator of Cardiovascular Risk. The Journal of Clinical Endocrinology & Metabolism, 88, 5163-5168.
https://doi.org/10.1210/jc.2003-030698

[19]   Wheeler, G.L., Shi, R., Beck, S.R., Langefeld, C.D., Lenchik, L., Wagenknecht, L.E., et al. (2005) Pericardial and Visceral Adipose Tissues Measured Volumetrically with Computed Tomography Are Highly Associated in Type 2 Diabetic Families. Investigative Radiology, 40, 97-101.
https://doi.org/10.1097/00004424-200502000-00007

[20]   Silaghi, A., Piercecchi-Marti, M.D., Grino, M., Leonetti, G., Alessi, M.C., Clement, K., et al. (2008) Epicardial Adipose Tissue Extent: Relationship with Age, Body Fat Distribution, and Coro-naropathy. Obesity (Silver Spring), 16, 2424-2430.
https://doi.org/10.1038/oby.2008.379

[21]   Gorter, P.M., de Vos, A.M., van der Graaf, Y., Stella, P.R., Doevendans, P.A., Meijs, M.F., et al. (2008) Relation of Epicardial and Pericoronary Fat to Coronary Atherosclerosis and Coronary Artery Calcium in Patients Undergoing Coronary Angiography. American Journal of Cardiology, 102, 380-385.
https://doi.org/10.1016/j.amjcard.2008.04.002

[22]   deVos, A.M., Prokop, M., Roos, C.J., Meijs, M.F., van der Schouw, Y.T., Rutten, A., et al. (2008) Peri-Coronary Epicardial Adipose Tissue Is Related to Cardiovascular Risk Factors and Coronary Artery Calcification in Post-Menopausal Women. European Heart Journal, 29, 777-783.
https://doi.org/10.1093/eurheartj/ehm564

[23]   Wang, C.P., Hsu, H.L., Hung, W.C., Yu, T.H., Chen, Y.H., Chiu, C.A., et al. (2009) Increased Epicardial Adipose Tissue (EAT) Volume in Type 2 Diabetes Mellitus and Association with Metabolic Syndrome and Severity of Coronary Atherosclerosis. Clinical Endocrinology (Oxf), 70, 876-882.
https://doi.org/10.1111/j.1365-2265.2008.03411.x

[24]   Rabkin, S.W. (2007) Epicardial Fat: Properties, Function and Relationship to Obesity. Obesity Reviews, 8, 253-261.
https://doi.org/10.1111/j.1467-789X.2006.00293.x

[25]   Gorter, P.M., van Lindert, A.S., de Vos, A.M., Meijs, M.F., van der Graaf, Y., Doevendans, P.A., et al. (2008) Quantification of Epicardial and Peri-Coronary Fat Using Cardiac Computed Tomography; Reproducibility and Relation with Obesity and Metabolic Syndrome in Patients Suspected of Coronary Artery Disease. Atherosclerosis, 197, 896-903.
https://doi.org/10.1016/j.atherosclerosis.2007.08.016

 
 
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