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 JBM  Vol.5 No.12 , December 2017
Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China
Abstract:
Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P < 0.01). The allelic frequencies and CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with T2DM group (P < 0.05). The GC + GG genotype in T2DM complicated with macroangiopathy group was significantly higher than that in T2DM group (P < 0.05). Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.
Cite this paper: Qi, B. , Yan, M. and Sun, Y. (2017) Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China. Journal of Biosciences and Medicines, 5, 17-23. doi: 10.4236/jbm.2017.512003.
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