T. Tanouchi, M. Kawamura, I. Ohyama, I. Kajiwara, Y. Iguchi, T. Okada, T. Miyamoto, K. Taniguchi, M. Hayashi, K. lizuka and M. Nakazawa, “Highly selective inhibitors of thromboxane synthetase. 2 Pyridine derivatives,” J Med Chem, Vol. 24, No. 10, 1981, pp. 1149- 1155.
 S. Moncada, R. Gryglewski, S. Bunting and J.R. Vane, “An enzyme isolated from arteries transforms prostaglandin endoperoxides to a stable substance that inhibits platelet aggregation,” Nature, Vol. 263, No. 5579, 1976, pp. 663-665.
 S. Mncada, E.A. Higgs and J.R. Vane, “Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation,” Lancet, Vol. 1, No. 8001, 1977, pp. 18-20.
 V. Seifert, D. Stolke, V. Kaever and H. Dietz. “Arachidonic acid metabolism following aneurysm rupture. Evaluation of cerebrospinal fluid and serum concentration of 6-keto-prostaglandin F1 alpha and thromboxane B2 in patients with subarachnoid hemorrhage,” Surg Neurol, Vol. 27, No.3, 1987, pp. 243-252.
 D.J. Boullin, S. Bunting, W.P. Blaso, T.M. Hunt and S. Moncada, “Responses of human and baboon arteries to prostaglandin endoperoxides and biologically generated and synthetic prostacyclin: their relevance to cerebral arterial spasm in man,” Br J Clin Pharmacol, Vol. 7, No. 2, 1979, pp. 139-147.
 L. Brandt, B. Ljunggren, K.E. Anderson, B. Hindfelt and T. Uski, “Effects of indomethacin and prostacyclin on isolated human pial arteries contracted by CSF from patients with aneurysmal SAH,” J Neurosurg, Vol. 55, No. 6, 1981, pp. 877-883.
 P.O. Grande, A.D. M?ller, C.H. Nordestr?n and U. Ungerstedt, “Low-dose prostacyclin in treatment of severe brain trauma evaluated with microdialysis and jugular bulb oxygen measurements,” Acta Anaesthesiol Scand, Vol. 44, No. 7, 2000, pp. 886-894.
 S. Naredi, M. Olivecrona, C. Lindgren, A.L. Ostlund, P.O. Grande and L.O. Koskinen, “An outcome study of severe traumatic head injury using the ‘Lund therapy’ with low-dose prostacyclin,” Acta Anaethesiol Scand, Vol. 45, No. 4, 2001, pp. 402-426.
 N. Hotta, N. Koh, F. Sakakibara, J. Nakamura, Y. Hamada, T. Hara, K. Mori, E. Nakashima, K. Naruse, H. Fukasawa, H. Kakuta and N. Sakamoto, “Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes,” Diabetes, Vol. 45, No. 3, 1996, pp. 361-366.
 M. Hazekawa, Y. Sakai, M. Yoshida, T. Haraguchi, T. Morisaki and T. Uchida. “Preparation of ONO-1301- loaded PLGA microspheres and their effect on nerve conduction velocity,” J Pharm Pharmacol, Vol. 63, 2011, pp. 362-368.
 M. Kataoka, N. Nagaya, T. Satoh, T. Itoh, S. Murakami, T. Iwase, Y. Miyahara, S. Kyotani, Y. Sakai, K. Kangawa and S. Ogawa, “A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension,” Am J Respir Crit Care Med, Vol. 172, No. 12, 2005, pp. 1575-1580.
 H. Obata, Y. Sakai, S. Ohnishi, S. Takeshita, H. Mori, M. Kodama, K. Kangawa, Y. Aizawa and N. Nagaya, “Single injection of a sustained-release prostacyclin analog improves pulmonary hypertension in rats,” Am J Respir Crit Care Med, Vol. 177, No. 2, 2008, pp. 195-201.
 S. Murakami, N. Nagaya, T. Itoh, M. Kataoka, T. Iwase, T. Horio, Y. Miyahara, Y. Sakai, K. Kangawa and H. Kikuma, “Prostacyclin agonist with thromboxane synthase inhibitory activity (ONO-1301) attenuates bleomycin-induced pulmonary fibrosis in mice,” Am J Physiol Lung Cell Mol Physiol, Vol. 290, No. 1, 2006, pp. 59-65.
 F. Pu, K. Mishima, K. Irie, K. Motohashi, Y. Tanaka, K. Orito, T. Egawa, Y. Kitamura, N. Egashira, K. Iwasaki and M. Fujiwara, “Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats.” J Pharmacol Sci, Vol. 104, No. 4, 2007, pp. 329-334.
 R.P. Ostrowski, A.R. Colohan and J. H. Zhang, “Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage,” J Cerebr Blood Flow Metab, Vol. 25, No. 5, 2005, pp. 554-571.
 R. Jin, B.H. Bay, V.T. Chow, P.H. Tan, V.C. Lin, “Metallothionein 1E mRNA is highly expressed in oestrogen receptor-negative human invasive ductal breast cancer,” Br J Cancer, Vol. 83, No. 3, 2000, pp. 319-323.
 T.F. Freund, A. Ylienen, R. Miettinen, A. Pitkanen, H. Lahtinen, K.G. Baimbridge and P.J. Riekkinen, “Pattern of neuronal death in the rat hippocampus after status epilepticus. Relationship to calcium binding protein content and ischemic vulnerability,” Brain Res Bull, Vol. 28, No. 1, 1992, pp. 27-38.
 H. Takamatsu, M. Tatsumi, S. Nitta, R. Ichise, K. Murakami, M. Iida, S. Nishikawa, K. Umemura, “Time course of progress to the chronic stage of middle cerebral artery occlusion models in rats,” Exp Brain Res, Vol. 146, No. 1, 2002, pp. 95-102.
 J.W. Ni, H. Ohta, K. Matsumoto and H. Watanabe, “Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats,” Brain Res, Vol. 635, No. 1-2, 1994, pp. 231-236.
 H. Nakatomi, T. Kuriu, S. Okabe, S. Yamamoto, O. Hatano, N. Kawahara, A. Tamura, T. Kirino and M. Nakafuku, “Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neuronal progenitors,” Cell, Vol. 110, No. 4, 2002, pp. 429-441.
 K. Hayakawa, K. Irie, K. Sano, T. Watanabe, S. Higuchi, M. Enoki, T. Nakano, K. Harada, S. Ishikane, T. Ikeda, M. Fujioka, K. Orito, K. Iwasaki, K. Mishima and M. Fujiwara, “Therapeutic time window of Cannabidiol treatment on delayed ischemic damage via high-mobility group box1-inhibition mechanism,” Biol Pharm Bull, Vol. 32, No. 9, 2009, pp. 1538-1544.
 C.P. Tiefenbacher, M. Ebert, F. Niroomand, S. Batkai, H. Tillmanns, R. Zimmermann and W. Kübler, “Inhibition of elastase improves myocardial function after repetitive ischemia and myocardial infarction in the rat heart,” Pflugers Arch, Vol. 433, No. 5, 1997, pp. 563-570.
 M. Kawai, N. Harada, H. Takeyama and K. Okajima, “Neutrophil elastase contributes to the development of ischemia/reperfusion-induced liver injury by decreasing the production of insulin-like growth factor-I in rats,” Transl Res, Vol. 155, No. 6, 2010, pp. 294-304.