OJEpi  Vol.7 No.4 , November 2017
Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice
Abstract: In the current study, hydatid cysts from livers and lungs of camels were obtained from Tambool slaughter house and protoscoleces were separated aseptically. 36-weeks-old Swiss mice (25 - 30 gram body weight males and females) were divided into two groups of 6 each: a prophylactic group dosed with 150 ml/kg of albendazole and mebendazole was given directly after injection with 2000 protoscoleces intraperitoneally for 10 consecutive days. The treated group was given a dose of 300 ml/kg of albendazole and mebendazole for 24 days with 4 days interval separated by 2 days and after 6 months of inoculation with protoscoleces, the two groups in addition to the control group were sacrificed and necropsied. The results revealed a significant difference in the development of hydatid cyst (p < 0.01). Inside the mice, small number of cysts was noticed in the group treated with albendazole and mebendazole compared to the control group, however, albendazole was highly efficacious than the mebendazole where the efficiency of albendazole reached 97% while the mebendazole efficiency rate was almost 50% which indicates that albendazole could be considered the drug of choice in the treatment of hydatid cyst.
Cite this paper: Ismail, E. , Saad, M. and Elsadig, A. (2017) Effect of Albendazole and Mebendazole on Hydatid Cyst of Mice. Open Journal of Epidemiology, 7, 307-316. doi: 10.4236/ojepi.2017.74025.

[1]   Torgerson, P.R. and Budke, C.M. (2003) Echinococcosis—An International Public Health Challenge. Research in Veterinary Science, 74, 191-202.

[2]   Teggi, A., Lastilla, G.M. and De Rosa, F. (1993) Therapy of Human Hydatid Disease with Mebendazole and Albendazole. Antimicrobial Agents and Chemotherapy, 37, 1679-1684.

[3]   Kern, P. (2003) Echinococcus Granulosus Infection: Clinical Presentation, Medical Treatment and Outcome. Langenbecks Archives in Surgery, 388, 13-20.

[4]   El-On, J. (2003) Benzimidazole Treatment of Cystic Echinococcosis. Acta Tropical, 85, 243-252.

[5]   Bekhti, A., Schaaps, J.P., Capron, M., Dessaint, J.P., Santoro, F. and Capron, A. (1977) Treatment of Hepatic Hydatid Disease with Mebendazole: Preliminary Results in Four Cases. British Medical Journal, 2, 1047-1051.

[6]   Horton, J. (2003) Albendazole for the Treatment of Echinococcosis. Fundamental and Clinical Pharmacology, 17, 205-212.

[7]   Pérez-Serrano, J., Casado, N., Denegri, G. and Rodríguez-Caabeiro, F. (1994) The Effects of Albendazole and Albendazole Sulphoxide Combination Therapy on Echinococcus Granulosus In Vitro. International Journal of Parasitology, 24, 219-224.

[8]   Pérez-Serrano, J., Martínez, J., Denegri, G., Casado, N., Bodega, G. and Rodríguez-Caabeiro, F. (2001) In Vitro Effect of Albendazole and Albendazole Sulphoxide on 70 and 60 kDa Heat Shock Proteins in Echinococcus Granulosus Protoscolices. Research and Reviews in Parasitology, 61, 67-71.

[9]   Rodríguez-Caabeiro, F., Casado, N. and Juárez-Peláez, E. (1989) Effect In Vitro of Praziquantel, Mebendazole Oxfendazole on Protoescolices of Echinococcus Granulosus. Review of Parasitology, 49, 77-83.

[10]   Stettler, M., Rossignol, J.F., Fink, R., Walker, M., Gottstein, B., Merli, M., Theurillat, R., Thormann, W., Dricot, E., Segers, R. and Hemphill, A. (2004) Secondary and Primary Murine Alveolar Echinococcosis: Combined Albendazole/Nitazoxanide Chemotherapy Exhibits Profound Anti-Parasitic Activity. International Journal Parasitology, 34, 615-24.

[11]   Polat, E., Aslan, M., Cakan, H., Saribas, S., Ipek, T. and Kocazeybek, B. (2009) The Effects of Albendazole and Povidone Iodine for Hydatid Cysts Protoscoleces, in Vitro and in Vivo. African Journal of Microbiology Research, 3, 743-746.

[12]   WHO/OIE (2011) Manual on Echinococcosis in Humans and Animals, a Public Health Problem of Global Concern. Acta Trop.

[13]   Gibson, T.E. (1969) Biology of Hydatidosis. Veterinary Record, 85, 320-322.

[14]   Anadol, D., Ozcelik, U., Kiper, N. and Gocmen, A. (2001) Treatment of Hydatid Disease. Pediatric Drugs, 3, 123-135.

[15]   Schipper, H.G. and Kager, P.A. (2004) Diagnosis and Treatment of Hepatic Echinococcosis: An Overview. Scandinavian Journal of Gastroenterology, No. 241, 50-55.

[16]   Shaw, J.M., Bornman, P.C. and Krige, J.E. (2006) Hydatid Disease of the Liver. South African Journal of Surgery, 44, 70-72, 74-77.

[17]   Keshmiri, M., Baharvahdat, H., Fattahi, S.H., Davachi, B., Dabiri, R.H., Baradaran, H. and Rajabzadeh, F. (2001) Albendazole versus Placebo in Treatment of Echinococcosis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 95, 190-194.

[18]   Daniel-Mwuambete, K., Ponce-Gordo, F., Torrado, J., Torrado, S. and Cuesta-Bandera, C. (2003) Effect of Two Formulations of Benzimidazole Carbamates on the Viability of Cysts of Echinococcus granulosus In Vivo. Parasitology, 10, 371-373.

[19]   Nakaya, K., Oomori, Y., Kutsumi, H. and Nakao, M. (1998) Morphological Changes of Larval Echinococcus multilocularis in Mice Treated with Albendazole or Mebendazole. Journal of Helminthology, 72, 349-354.

[20]   Ammari, F.F. and Omari, A.K. (2002) Surgery and Postoperative Mebendazole in the Treatment of Hydatid Disease. Saudi Medical Journal, 23, 568-571.