SS  Vol.2 No.8 , October 2011
Leptomeningeal Carcinomatosis Presenting Early in Non-Small Cell Lung Cancer
Abstract
Purpose: We present the case of a patient presenting with altered mental status on post-operative day seven after a diagnostic lung biopsy. The diagnosis of carcinomatous letomeningeal metastasis was confirmed. Methods: We discuss meningeal carcinomatosis in lung cancer, and describe challenges to diagnosis, therapy, and prognosis. Results: A review of the literature describing the clinical and oncologic principles of letomeningeal carcinomatosis in lung cancer is performed. Discussion: Leptomeningeal carcinomatosis (LC) occurs in approximately 5% of patients with non-small cell lung cancer and incurs a bleak prognosis. Presenting neurologic symptoms can be varied and diagnosis is confirmed via lumbar puncture and cerebrospinal fluid cytology. Few data exist regarding optimal treatment, although intrathecal chemotherapy has been shown to provide a modest improvement in median survival.

Cite this paper
nullE. Teitelbaum, S. Hasselquist, I. Tabbara and G. Trachiotis, "Leptomeningeal Carcinomatosis Presenting Early in Non-Small Cell Lung Cancer," Surgical Science, Vol. 2 No. 8, 2011, pp. 427-429. doi: 10.4236/ss.2011.28093.
References

[1]   T. W. Shields, J. Locicero, C. E. Reed and R. H. Feins, “General Thoracic Surgery,” 7th Edition, Williams & Wilkins, Malvern, 2009.

[2]   M. C. Chamberlain and P. Kormanik, “Carcinoma Meningitis Secondary to Non-small Cell Lung Cancer: Combined Modality Therapy,” Archives of Neurology, Vol. 55, No. 4, 1998, pp. 506-512. doi:10.1001/archneur.55.4.506

[3]   N. Pavlidis, “The Diagnostic and Therapeutic Management of Leptomeningeal Carcinomatosis,” Annals of Oncology, Vol. 15, Supplement 4, 2004, pp. iv285-iv291. doi:10.1093/annonc/mdh941

[4]   M. B. Fukui, C. C. Meltzer, E. Kanal and J. G. Smirniotopoulos, “MR Imaging of the Meninges,” Radiology, Vol. 201, No. 3, 1996, pp. 605-612.

[5]   E. T. Wong and J. T. Joseph, “Meningeal Carcinomatosis in Lung Cancer,” Journal of Clinical Oncology, Vol. 18, No. 15, 2000, pp. 2926-2927.

[6]   W. Wasserstrom, J. Glass and J. Posner, “Diagnosis and Treatment of Leptomeningeal Metastases from Solid Tumors: Experience with 90 Patients,” Cancer, Vol. 49, No. 4, 1982, pp. 759-772. doi:10.1002/1097-0142(19820215)49:4<759::AID-CNCR2820490427>3.0.CO;2-7

[7]   M. Balm and J. Hammack, “Leptomeningeal Carcinomatosis,” Archives of Neurology, Vol. 53, No. 7, 1996, pp. 626-632.

[8]   M. Westphal, O. Heese and M. de Wit, “Intracranial Metastases: Therapeutic Options,” Annals of Oncology, Vol. 14, Supplement 3, 2003, pp. iii4-10. doi:10.1093/annonc/mdg741

 
 
Top