Clinicopathological and Immunohistochemical Features of Triple Negative Breast Cancer

Heng  Chen; Wei  Tan; Jinjun  Li

doi:10.4236/abcr.2017.64008

Heng Chen^1,2, Jinjun Li²^*, Wei Tan¹^*

Abstract: Objective: To investigate the clinicopathological and immunohistochemical features of triple-negative breast cancer. Methods: The clinicopathological and immunohistochemical data (Ki-67, CK5/6, EGFR, E-Ca, SAM, P53, P63, FAS) of 199 female patients who were treated for breast cancer in thyroid and breast surgery of Xiaogan Central Hospital from January 2015 to December 2016 was retrospectively analyzed by using spss22.0 statistical software and chi-square analysis. Results: Triple-negative breast cancer (replaced by TNBC below) and non-triple negative breast cancer (replaced by non TNBC below) in age, tumor size, lymph node metastasis, SAM, P53, P63 and FAS have no statistical difference (P > 0.05, see Table 1), while in WHO grade of invasive ductal carcinoma, KI-67, CK5/6, EGFR, E-Ca they have statistical differences (P < 0.05, see Table 1). The invasive ductal carcinoma WHO grade of TNBC is higher than that of non TNBC. It’s positive rate of Ki-67, CK5/6, EGFR (96.67%, 58.33%, 72.22%) and negative rate of E-Ca (68.18%) are higher than those of non TNBC (75.74%, 29.03%, 18.92%, 30.38%) (P < 0.05, see Table 1). Conclusions: The invasive ductal carcinoma WHO grade of TNBC is higher than that of non TNBC, while it’s Ki-67, CK5/6, EGFR positive rate and the negative rate of E-Ca are significantly higher than those of non TNBC. The immunohistochemical index above is expected to become potential targets for the treatment of TNBC.

Keywords: TNBC, Clinicopathological Features, Immunohistochemistry

Cite this paper: Chen, H. , Li, J. and Tan, W. (2017) Clinicopathological and Immunohistochemical Features of Triple Negative Breast Cancer. Advances in Breast Cancer Research, 6, 93-99. doi: 10.4236/abcr.2017.64008.

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