OJI  Vol.1 No.2 , September 2011
Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin
Abstract: Mannose-binding lectin (MBL), a mammalian lectin, is a pattern recognition molecule of the innate immune system and recognizes carbo-hydrates that are exposed on pathogens. In this study, we observed that fructose down regu-lates MBL-mediated innate immune mechanisms against both influenza A virus (IAV) and Staphy-lococcus aureus. These mechanisms include the lectin complement pathway and coagulation enzyme-like activities on both pathogens. Fur-thermore, fructose also reduces MBL-mediated phagocytosis of S. aureus and IAV and MBL- mediated IAV infection to epithelial cells. In contrast, sucrose inhibits MBL-mediated im-mune mechanisms against S. aureus but not IAV. Together, our studies show that dietary sugars, in particular fructose, negatively regulate the innate immunity against viral and bacterial pathogens.
Cite this paper: nullTakahashi, K. , Chang, W. , Moyo, P. , White, M. , Meelu, P. , Verma, A. , Stahl, G. , Hartshorn, K. and Yajnik, V. (2011) Dietary sugars inhibit biologic functions of the pattern recognition molecule, mannose-binding lectin. Open Journal of Immunology, 1, 41-49. doi: 10.4236/oji.2011.12005.

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