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 IJCM  Vol.8 No.6 , June 2017
Effect of Conjugated Estrogen in Stress Urinary Incontinence in Women with Menopause
Abstract: Menopause is one of the natural stages of life of women that is associated with instability of vasomotor, flushing, sweating, anxiety and depression, urogenital atrophy and urinary problems. The age range of physiological event is between 48 - 55 years old. With regard to the role of genetics, nutrition and geographical conditions of the age of menopause in Iranian women is lower than and among 46 - 53 years. With the increase in life expectancy in recent decades, duration of menopause is increased and almost involved a third of the life of women so special issues of this era have had more attention. Since menopause is not the end of the life of a woman and keep her physical and mental health and problems resulting from the process of menopause such as urinary problems and incontinence will lead to improve the quality of life in this period. Many studies have tried to find a therapy for postmenopausal women with stress urinary incontinence using hormone. So this article seeks to examine the effect of conjugated estrogen in stress urinary incontinence of menopausal women with using the library method. The survey showed that by starting menopause, decreasing estrogen causes atrophy of mucosa of urogenital and the lining of the urethra and bladder, estrogen causes to maintain muscle tonicity. Also sacral nerves are also rich in estrogen receptors and by estrogen deficiency, elasticity of the urinary system decreases. Estrogen deficiency causes excitability of nerves and frequency of urine. So estrogen can increase the resistance of the urethra, bladder sensory threshold and sensitivity in Adorno in smooth muscles of the urethra and the rest of detrusor.
Cite this paper: Khanjani, S. and Khanjani, S. (2017) Effect of Conjugated Estrogen in Stress Urinary Incontinence in Women with Menopause. International Journal of Clinical Medicine, 8, 375-385. doi: 10.4236/ijcm.2017.86035.
References

[1]   Denfort, D. (2002) Obstetrics and Gynecology. Sarami, A., et al., Trans., Miri Press, Tehran.

[2]   Novak, E. (2003) Gynecological. Dastjerdi, V., et al., Trans., Nurdanesh Publications, Tehran.

[3]   Aghazadeh Naieni, A. (1995) What Women Need to Know. Ansariyan Press, Qom.

[4]   Ebrahim, K., Ramazanpour, M. and Rezaei Sahraie, A. (2010). The Effect of Eight Weeks of Aerobic and Increasing the Hormones Estrogen and Some Factors Affecting on Bone Mass in Postmenopausal Women Disabled. Iranian Journal of Endocrinology and Metabolism, 12, 401-408.

[5]   Jokhio, A.H., Rizvi, R.M., Rizvi, J. and Macarthur, C. (2013) Urinary Incontinence in Women in Rural Pakistan: Prevalence, Severity, Associated Factors and Impact on Life. BJOG: An International Journal of Obstetrics and Gynaecology, 120, 180-186.
https://doi.org/10.1111/1471-0528.12074

[6]   Kian, Z. (2009) Effect of Pelvic Floor Muscle Exercise on Quality of Life of Women with Stress Urinary Incontinence in the Postpartum Period. MSC Thesis, Tehran University of Medical Sciences, Tehran. (In Persian)

[7]   Lamiian, M., SHagerd Hadad, M., Goshtasebi, A. and Massoomi, R. (2010) Comparison of Surgical and Medical Therapy on Quality of Life in Women with Urinary Incontinence. Payesh, 10, 525-532.( In Persian)

[8]   Tashakori, M., Moghimi, A., Pilevariyan, A. and moghimiyan, M. (2006) Study of Severity and Prevalence of Stress Incontinent in Menopausal Working Women in Khorasan. Iranian Gynecol Midwifer Infertilit J, 9, 47-52. (In Persian)

[9]   Nojomi, M., Baharvand, P. and Kashanian, M. (2009) Validation of Incontinence Quality of Life Questionnaire (I-QOL) in Incontinent Women. RJMS, 16, 153-161. (In Persian)

[10]   Mladenovic Segedi, L., Segedi, D. and Parezanovic Ilic, K. (2011) Quality of Life in Woman with Urinary Incontinence. Medicinski Glasnik (Zenica), 8, 237-242.

[11]   Warren-Findlow, J. and Prohaska, T.R. (2008) Families, Social Support and Self Care among Older African-American Women with Chronic Illness. American Journal of Health Promotion, 22, 342-349.

[12]   Heidari, M., Alhani, F., Kazemnejad, A. and Moezzi, F. (2007) The Effect of Empowerment Model on Quality of Life of Diabetic Adolescents. Iranian Journal of Pediatrics, 17, 87-94. (In Persian)

[13]   Stanhop, M. and Lancaster, J. (2008) Community & Public Health Nursing. 7th Edition, Mosby, Maryland Heights.

[14]   Broome, B.A. (2003) The Impact of Urinary Incontinence on Self-Efficacy and Quality of Life. Health and Quality of Life Outcomes, 1, 35.
https://doi.org/10.1186/1477-7525-1-35

[15]   Suckling, J., Lethaby, A. and Kennedy, R. (2006) Local Oestrogen for Vaginal Atrophy in Postmenopausal Women. Cochrane Database of Systematic Reviews, 4, CD001500.

[16]   Schmidt, J.W., Wollner, D., Curcio, J., Riedlinger, J. and Kim, L.S. (2006) Hormone Replacement Therapy in Menopausal Women: Past Problems and Future Possibilities. Gynecological Endocrinology, 22, 564-577.
https://doi.org/10.1080/09513590600927017

[17]   Kim, D.K. and Chancellor, M.B. (2006) Is Estrogen for Urinary Incontinence Good or Bad? Reviews in Urology, 8, 91-92.

[18]   Edwall, L., Carlström, K. and Fianu, J.A. (2008) Markers of Collagen Synthesis and Degradation in Urogenital Tissue and Serum from Women with and without Uterovaginal Prolapse. Molecular Human Reproduction, 14, 193-197.
https://doi.org/10.1093/molehr/gan006

[19]   Mattox, J.H. (1998) Core Text Book of Obstetrics & Gynecology. 2nd Edition, Mosby, St. Louis.

[20]   Scott, J.R., Gibbs, R.S. and Karlan, B.Y. (2003) Danforth’s Obstetrics & Gynecology. 8th Edition, Lippincott Williams & Wilkins, Philadelphia.

[21]   Satherland, C. (2001) Women’s Health: A Handbook for Nurse. 2nd Edition, Churchill Living Stone, Edinburg.

[22]   Quinn, Y.E., Marcia, S. and Zamania, D. (2003) Women’s Health: A Primary Care Clinical Guide. 3rd Edition, Prentice Hall International, London.

[23]   Skaaby, T., Husemoen, L.L., Pisinger, C., Jorgensen, T., Thuesen, B.H., Fenger, M. and Linneberg, A. (2012) Vitamin D Status and Cause-Specific Mortality: A General Population Study. PLoS One, 7, 42-52.
https://doi.org/10.1371/journal.pone.0052423

[24]   Berek, J.S., Rinehart, R.D., Adams, H.P.J. and Adashi, E.Y. (2002) Novak’s Gynecology. 13th Edition, Lippincott Williams & Wilkins, Philadelphia.

[25]   Abu-Mouch, S., Fireman, Z., Jarchovsky, J., Zeina, A.R. and Assy, N. (2011) Vitamin D Supplementation Improves Sustained Virologic Response In Chronic Hepatitis C (Genotype 1)-Naive Patients. World Journal of Gastroenterology, 17, 5184-5190.
https://doi.org/10.3748/wjg.v17.i47.5184

[26]   Sakala, E.P. (2005) High-Yield Obstetrics and Gynecology. 2nd Edition, Lippincott Williams & Wilkins, New York.

[27]   Smeltzer, S.C. and Bare, B.G. (2000) Brunner & Suddarth’s Text Book of Medical-Surgical Nursing. 9th Edition, Lippincott, Philadelphia.

[28]   Rahman, A. and Branch, A.D. (2013) Vitamin D for Your Patients with Chronic Hepatitis C? Journal of Hepatology, 51, 184-189.
https://doi.org/10.1016/j.jhep.2012.07.026

[29]   Hacker, N.F., Moore, J.G. and Gambone, J.C. (2004) Essentials of Obstetrics and Gynecology. 4th Edition, Saunders, Philadelphia.

[30]   Stirrat, G.M. (2000) Aids to Obstetrics and Gynecology for Mrcog. 4th Edition, Churchill Living Stone, Edinburgh.

[31]   Sanfillippo, J.S. and Smith, R.P. (1998) Primary Care in Obstetric & Gyncecology: A Handbook for Clinicians. Springer, New York.

[32]   Sherburn, M., Guthrie, J.R., Dudley, E.C., O’connell, H.E. and Dennerstein, L. (2001) Is Incontinence Associated with Menopaus? Obstetrics & Gynecology, 98, 628-633.

[33]   Melmed, S., Polonsky, K., Larsen, P.R. and Kronenberg, H. (2011) Williams Textbook of Endocrinology. 13th Edition, Elsevier, Amsterdam.

[34]   Bai, S.W., Jung, Y.W., Kwon, H.S., et al. (2004) The Role of Estrogen Receptor, Progenterone Receptor and p53 in Development of Stress Urinary Incontinence. Yonsei Medical Journal, 45, 885-890. https://doi.org/10.3349/ymj.2004.45.5.885

[35]   Zhu, L., Lang, J., Feng, R., Chen, J. and Wong, F. (2004) Estrogen Receptor in Pelvic Floor Tissues in Patients with Stress Urinary Incontinence. International Urogynecology Journal and Pelvic Floor Dysfunction, 15, 340-343.

[36]   Skala, C.E., Petry, I.B., Albrich, S., Puhl, A., Naumann, G. and Koelbl, H. (2011) The Effect of Genital and Lower Urinary Tract Symptoms on Steroid Receptor Expression in Women with Genital Prolapsed. International Urogynecology Journal, 22, 705-712.
https://doi.org/10.1007/s00192-010-1327-6

[37]   Connel, K.A., Guess, M.K., Chen, H.W., Lynch, T., Bercik, R. and Taylor, H.S. (2009) HOXA11 Promotes Fibroblast Proliferation and Regulates p53 in Uterosacral Ligaments. Reproductive Sciences, 16, 697-700.
https://doi.org/10.1177/1933719109334260

[38]   Lang, J.H., Zhu, L., Sun, Z.J. and Chen, J. (2003) Estrogen Level and Estrogen Receptors in Patient with Stress Urinary Incontinence and Pelvic Organ Prolapsed. International Journal of Gynecology & Obstetrics, 80, 35-39.

[39]   Hish, Ch., Su, T. and Change, Sh. (2008) Prevalence of and Attitude toward Urinary Incontinence in Postmenopausal Women. International Journal of Gynecology & Obstetrics, 100, 171-174.

[40]   Gulseren, L., Kalafat, D., Mandaci, H., Gulseren, S. and Comli, L. (2005) Effect of Tibolone on the Quality of Life, Anxiety-Depression Levels and Cognitive Function in Natural Menopause: An Observational Follow-Up Study. Australian and New Zealand Journal of Obstetrics and Gynaecology, 45, 71-73.
https://doi.org/10.1111/j.1479-828X.2005.00345.x

[41]   Longo, D., Fauci, A., Kasper, D., Hauser, S., Jamson, J. and Loscalzo, J. (2012) Harrison’s Principles of Internal Medicine. Textbook Edition, McGraw-Hill Education, New York.

[42]   Ashrafi, M., Kazemi-Ashtiani, S. and Eshrati, B. (2007) Menopausal Age Mean and Influence Variables on It in Tehran Persian. Kosar Medical Journal, 12, 75-82.

[43]   Speroff, L. and Fritz, M.A. (2005) Clinical Gynecology Endocrinology and Infertility. 7th Edition, Walters Kluwer Company, New York, 275-662.

[44]   Green, S., Walter, P. and Kumar, V. (1986) Human Estrogen Receptor DNA Sequence, Expression and Homology. Nature, 320, 134-139.
https://doi.org/10.1038/320134a0

[45]   Kuiper, G.G., Enmark, E. and Pelto-Huikko, M. (1996) Cloning of a Noval Receptor Expressed in Rat Prostate and Ovary. Proceedings of the National Academy of Sciences, 93, 5925-5928.
https://doi.org/10.1073/pnas.93.12.5925

[46]   Keane, D. and Sullivan, S. (2000) Urinary Incontinence: Anatomy, Physiology and Pathophysiology. Obstetrics & Gynecology, 14, 207-226.
https://doi.org/10.1053/beog.1999.0072

[47]   Shelton Broom, B. (2003) The Impact of Urinary Incontinence on Self-Efficacy and Quality of Life. Internal Medicine, 1, 35.

 
 
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