Drug trafficking with intracorporal concealment of packets for transport, in this study referred to as body packing (BP), is known in the medical community since the 70s  . Today cases in all age groups, including children and pregnant women, have been reported      . Though many possibilities for its detection exist, ranging from X-ray    -  and CT       to MRI  , ultrasound   and less well known methods as low-dose linear slit digital radiography “LSDR and Lodox”  , the most established examination methods remain X-ray and CT.
Since imaging characteristics of BP vary it remains difficult to prove or exclude BP as it is not limited to a single substance (e.g. heroin, cocaine) or mode of packaging (e.g. condom, foil wrapping)  . A further complicating factor can be the localisation of the packets within the gastrointestinal tract and consequently accompanying superimposed structures such as gas, compacted stool or bony structures, each depending on the time and mode of application (oral, rectal, vaginal). As a consequence, imaging characteristics differ and diagnostic performance of both X-ray and CT ultimately vary, deeming a plain X-ray often insufficient.
Recently more studies have given way to the scout view as a diagnostic image in select clinical questions   ; one study demonstrated an especially high PPV in body packers with packets in the upper and mid GI  , while an animal study could even show better delineation of foreign objects with a CT scout view compared to X-ray, while applying equivalent or lower radiation doses when compared to X-ray  .
Even though a CT scout view differs drastically in radiation dose from a CT scan or even plain X-ray, its diagnostic performance remains to be evaluated in the clinical setting of body packing.
Though in most cases radiologists are not involved directly in the legal investigation, they determine which examination method to use and it remains their obligation to protect any individual undergoing such examinations from unnecessary risks  that any radiation based study may pose.
The purpose of this study, therefore, was to analyze the diagnostic performance of the CT scout view against that of the CT examination in cases of suspected BP performed at our department.
2. Material and Methods
The study has been conducted retrospectively and was approved by the local ethics committee in our tertiary care center.
We included at total of 43 consecutive CT examinations in cases of suspected body packing between July 2011 and June 2013. Two individuals have been detained on different occasions with the suspicion of body packing, each occasion had been consider as an independent case.
We examined 14 female (33%) and 29 male (67%) cases with a mean age of 38 ± 9 years.
Individuals with apparent signs of intoxication, bowel obstruction or perforation were managed medically or surgically and not considered in this study.
2.1. CT Imaging
Non contrast enhanced CT-imaging was acquired from the dome of the diaphragm to the pubic symphysis.
Images were acquired with a 40-row Multislice-CT-scanner (SOMATOM Definition AS, Siemens Healthcare, Erlangen, Germany) with the following parameters: tube voltage, 100 kV; tube current modulation (Care Dose); fixed reference current, 60 mAs; collimation, 0.6 × 40; rotation time, 500 milliseconds; pitch, 1.4. For scan volume planning a standard scout view at 120 kV with a tube current of 35 mA was acquired anteroposteriorly.
No IV or enteral contrast medium was used.
Images were isovolumetrically reconstructed using a filtered back projection soft tissue kernel (B20f) with a slice thickness of 1 mm (increment 0.7 mm) and 5 mm (increment 4 mm) in axial direction, respectively. Multislice reformations were performed sagittally and coronally.
2.2. Image Evaluation
Images were read on a routine digital reporting station with standard PACS viewer (iSite Radiology, Philips Healthcare, Amsterdam, Netherlands). CT images and CT scout views were evaluated independently from each in randomized order, beginning with the CT scout views.
The images were rated on the presence of foreign objects on a four point Likert scale (definite BP, likely BP, improbable BP, no BP) by three radiologists with 4, 5 and 7 years of clinical experience, respectively. For the scout view bowel gas was rated on a four point Likert scale (1 no gas, 4 meteorism). If a foreign body was identified on the CT scan, maximum and minimum diameters were recorded in the coronal reformation.
2.3. Standard of Reference
The standard of reference for this study is a consensus read of the CT images with knowledge of the legal body’s investigation results, in which the authorities have consistently recorded the type and weight of active illegal substance.
“R”  was used for the statistical analysis. The diagnostic performance of CT scout view on the basis of the median rating of three observers was compared to that of CT scan. We compared both sensitivity and specificity of CT scans and CT scout views. Values of definite and likely BP were summarized as positive result; values of improbable and definitely no BP were summarized as negative result. Furthermore, we evaluated the agreement of each CT scan and its corresponding CT scout view with the Cohen’s kappa coefficient. The agreement of the three observers with respect to CT scan and CT scout view was evaluated with Cohen’s kappa coefficient separately. In addition, we evaluated the influence of packet size and bowel gas on the detection rate of CT scout view.
A total of 11 positive cases of body packing were identified. In 10 (91%) of the cases packets were relatively large and spares in number (3 or less), in 7 (64%) a single packet has been identified. 6 (55%) of the packets were located rectally, 4 (36%) vaginally and in 1 (9%) case multiple small packets of approximately 1 cm in size were found to have been ingested orally. Maximum and minimum diameters were 5.9 ± 3 cm and 2.9 ± 1.4 cm, respectively. The mean weight of packets was 7.5 ± 4.2 g (range 2 - 54 g). In 73% (n = 8) of cases heroin had been detected, other drugs such as cocaine (n = 1) and cannabis (n = 1) were encountered once, respectively. One packet was identified retrospectively and its content could therefore not be identified. The average effective dose was 3.8 ± 2.1 mSv for CT, of that 0.12 ± 0.01 mSv was required for the CT scout view.
Interpretation of Results
The prevalence of body packing was 26% (11/43). CT scout view had a sensitivity of 72% (8/11) and a specificity of 84% (27/32). CT scan had a sensitivity of 100% and a specificity of 97% (31/32). CT scout view failed to detect 3 cases of true body packing, and falsely detected 5 cases of body packing. CT scan never failed to detect true body packing and detected body packing falsely only once.
Cohen’s kappa coefficient for the comparison of CT scout view and CT scan on patient level showed a substantial agreement (Cohen’s kappa of 0.61) between the two methods, indicating that CT scout view is a good index for CT scan.
For CT scout view the size of the packet (maximal diameter) may have an influence on the detection rate of body packing. The model including the size, fitted the data better than the model without that parameter (model comparison with analysis of variance yielded a p = 0.01076). However, size was not statistically significant in the logistic regression with the relatively small number of positive cases. As sensitivity was 100% for CT scan, the size of the packet did not have an influence on the detection rate.
If readers were viewed individually, and only considered the cases read positively with high confidence, PPV increased to 92% with a correspondingly high likelihood ratio. However, considering the relatively low number of positive cases (n = 11), statistical significance was not reached. No significant change for NPV could be observed, as a negative read with high confidence was only given 4 times in total.
X-ray and CT are the modalities of choice in clinical practice in the evaluation of BP today as they are both readily available and rapid, and only require limited cooperation of the individual    -     . Often enough an X-ray is read as equivocal in the evaluation of BP, whereas other times a diagnosis of BP can be can be made with confidence.
This study’s goal was to evaluate the diagnostic information contained in the CT scout view in suspects of BP.
The sensitivity of a typical X-ray in diagnosing BP has been reported to ranging from 47% - 95%   , the sensitivity of CT has been reported to be close to 100%   . The sensitivity of CT scout view in our human collective of mostly body stuffers was 73% with an especially high PPV, consistent with the higher sensitivity of CT scout view when compared to X-ray as reported in an animal model  or for body packing with packets in the upper and mid GI  .
Nevertheless, in many cases it remains difficult to prove or exclude body packing even with the many times good of foreign objects achieved with the CT scout view, as body packing is not limited to a single substance (heroin, cocaine e.g.) or mode of packaging (condom, foil wrapping e.g.)  or other complication factors as the localization of the packets within the gastrointestinal tract and consequently accompanying superimposed structures such as gas, compacted stool or bony structures, each depending on the time and mode of application (oral, rectal, vaginal); especially hardened stool in the rectum with surrounding gas was many times difficult to differentiate from a packet. As a consequence of differing imaging characteristics, CT scout view is exposed to the same challenges any projection radiography.
However, if a diagnosis of BP can be made with high confidence, an example of which is shown in Figure 1 and Figure 2, the examination can be concluded. In other cases as e.g. depicted in Figure 3 one can proceed to the CT scan without further delay, streamlining the workup of BP.
An additional benefit of the CT scout view is its extremely low dose (reduction of roughly 40 fold compared to the CT scan and up to 5 fold when compared to X-ray   ) and when followed up by the actual CT scan, being essentially dose neutral.
There were several limitations to our study. Drug packets found were mostly very spare or solitary in number, therefore many frequently encountered X-ray
Figure 1. (a) CT scout view of a body packing suspect with a single large well visible packet in projection of the rectum. (b) Low-dose CT in coronal plane of the same individual.
Figure 2. CT scout view of a body packing suspect clearly showing multiple smaller foreign bodies in the rectum.
Figure 3. Low-dose CT of a body packing suspect with multiple round objects in the transverse colon with a diameter of approximately 1 cm in (a) coronal and (b) axial plain. Notice the X-ray density is very similar to the surrounding stool. The CT scout view in this case was not suspicious.
signs such as parallelism or “tic-tac” sign  were not present. As this is owed to local habits generalization to other regions may be difficult. Similarly, heroin in powder form combined with cutting agents was by far the most frequently encountered drug; liquid packets as increasingly reported in other studies were not found, possibly complicating generalization further.
Packet characteristics, such as number of packets, packaging, total weight, or composition were not consistently recorded and could therefore not be evaluated, e.g. only in three cases the packaging material was recorded by the authorities.
Finally, the standard of reference is intrinsically flawed, being limited by diagnostic and legal limitations: The legal body’s investigation and the consensus reading of images could not in every positive case be verified; either the foreign object was overlooked when initially reported, which then let to the release of the suspect or, although a foreign object was reported, which also was clearly visible on the consensus read and the suspect was placed in confinement, in some cases no such object could be retrieved.
CT scout view demonstrated good delineation of packets in body pushers with an especially good PPV and slightly higher sensitivity and specificity, when compared to X-ray. Though slightly less severe, its limitations in the detection of body packing, namely the relatively low specificity and sensitivity, are identical to X-ray. Despite these major limitations, the information contained within the CT scout view should be utilized and advancement to CT scan should be reserved for equivocal or negative cases, when suspicion remains high.
If CT scout view were treated as a diagnostic image, some CT scans may be omitted, thereby maintaining streamlined operations and achieving further dose reduction jointly in the workup of body packing.
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