Back
 IJMPCERO  Vol.6 No.2 , May 2017
TrueBeam Low Dose Rate Investigation for Pulsed Reduced Dose Rate IMRT
Abstract: The capability of the TrueBeam treatment system to deliver step and shoot IMRT plans at low dose rates was evaluated. Beam characteristics during low dose rates (5 to 100 MU/min) were evaluated for consistency using a planar ion chamber array. MU constancy, linearity, and beam profile symmetry were all found to be equivalent within 0.5%. The response of the Scandi Dos Delta 4 system was also evaluated at low dose rates of using static open beams compared to ion chamber measurements, and step and shoot IMRT plans comparing 5 - 20 MU/min and 100 MU/min dose rates, with a maximum observed absolute dose difference of 0.8% and equivalence margin of 0.2%. The Gamma Index and measurement reproducibility were also found to be equivalent.
Cite this paper: Geurts, M. (2017) TrueBeam Low Dose Rate Investigation for Pulsed Reduced Dose Rate IMRT. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 6, 139-149. doi: 10.4236/ijmpcero.2017.62013.
References

[1]   Cannon, G.M., Tomé, W.A., Robins, H.I. and Howard, S.P. (2007) Pulsed Reduced Dose-Rate Radiotherapy: Case Report: A Novel Re-Treatment Strategy in the Management of Recurrent Glioblastoma Multiforme. Journal of Neuro-Oncology, 83, 307-311.
https://doi.org/10.1007/s11060-007-9329-z

[2]   Richards, G.M., Tomé, W.A., Robins, H.I., Stewart, J.A., Welsh, J.S., Mahler, P.A., et al. (2009) Pulsed Reduced Dose-Rate Radiotherapy: A Novel Locoregional Retreatment Strategy for Breast Cancer Recurrence in the Previously Irradiated Chest Wall, Axilla, or Supraclavicular Region. Breast Cancer Research and Treatment, 114, 307-313.
https://doi.org/10.1007/s10549-008-9995-3

[3]   Adkison, J.B., Tomé, W., Seo, S., Richards, G.M., Robins, H.I., Rassmussen, K., et al. (2011) Reirradiation of Large-Volume Recurrent Glioma with Pulsed Reduced Dose Rate Radiotherapy. International Journal of Radiation Oncology, Biology, Physicss, 79, 835-841.
https://doi.org/10.1016/j.ijrobp.2009.11.058

[4]   Fowler, J.F., Welsh, J.S. and Howard, S.P. (2004) Loss of Biological Effect in Prolonged Fraction Delivery. International Journal of Radiation Oncology, Biology, Physics, 59, 242-249.
https://doi.org/10.1016/j.ijrobp.2004.01.004

[5]   Tomé, W.A. and Howard, S.P. (2007) On the Possible Increase in Local Tumour Control Probability for Gliomas Exhibiting Low Dose Hyper-Radiosensitivity Using a Pulsed Schedule. The British Journal of Radiology, 80, 32-37.
https://doi.org/10.1259/bjr/15764945

[6]   Kang, S., Lang, J., Wang, P., Li, J., Lin, M., Chen, X., et al. (2014) Optimization Strategies for Pulsed Low-Dose-Rate IMRT of Recurrent Lung and Head and Neck Cancers. Journal of Applied Clinical Medical Physics, 15, 4661.
https://doi.org/10.1120/jacmp.v15i3.4661

[7]   Ma, C.M., Lin, M.H., Dai, X.F., Koren, S., Klayton, T., Wang, L., et al. (2012) Investigation of Pulsed Low Dose Rate Radiotherapy Using Dynamic Arc Delivery Techniques. Physics in Medicine and Biology, 57, 4613-4626.
https://doi.org/10.1088/0031-9155/57/14/4613

[8]   Tyagi, N., Yang, K., Sandhu, R., Yan, D., Park, S.S., Chen, P.Y. and Marples, B. (2013) External Beam Pulsed Low Dose Radiotherapy Using Volumetric Modulated Arc Therapy: Planning and Delivery. Medical Physics, 40, Article Number: 011704.
https://doi.org/10.1118/1.4769119

[9]   Rong, Y., Paliwal, B., Howard, S.P. and Welsh, J. (2011) Treatment Planning for Pulsed Reduced Dose-Rate Radiotherapy in Helical Tomotherapy. International Journal of Radiation Oncology, Biology, Physics, 79, 934-942.
https://doi.org/10.1016/j.ijrobp.2010.05.055

[10]   Geurts, M. (2016) TU-H-BRC-04: Feasibility of Using Tomo Direct for Pulsed Reduced Dose-Rate Radiotherapy. Medical Physics, 43, 3766.
https://doi.org/10.1118/1.4957611

[11]   Smilowitz, J.B., Das, I.J., Feygelman, V., Fraass, B.A., Geurts, M., Kry, S.F., et al. (2016) AAPM Medical Physics Practice Guideline 5.a.: Commissioning and QA of Treatment Planning Dose Calculations—Megavoltage Photon and Electron Beams. Journal of Applied Clinical Medical Physics, 17, 457.
https://doi.org/10.1120/jacmp.v17i1.6166

[12]   Jursinic, P.A. (2013) Dependence of Diode Sensitivity on the Pulse Rate of Delivered Radiation. Medical Physics, 40, 021720.
https://doi.org/10.1118/1.4788763

[13]   Ahmed, S., Nelms, B., Kozelka, J., Zhang, G., Moros, E. and Feygelman, V. (2016) Validation of an Improved Helical Diode Array and Dose Reconstruction Software Using TG-244 Datasets and Stringent Dose Comparison Criteria. Journal of Applied Clinical Medical Physics, 17, 6414.
https://doi.org/10.1120/jacmp.v17i6.6414

[14]   Gao, S., Balter, P.A., Rose, M. and Simon, W.E. (2016) A Comparison of Methods for Monitoring Photon Beam Energy Constancy. Journal of Applied Clinical Medical Physics, 17, 242-253.
https://doi.org/10.1120/jacmp.v17i6.6454

[15]   Sun Nuclear Corporation (2016) IC Profiler Reference Guide. Sun Nuclear Corporation, Melbourne

[16]   Schuirmann, D.L. (1981) On Hypothesis Testing to Determine If the Mean of a Normal Distribution Is Contained in a Known Interval. Biometrics, 37, 617.

[17]   Westlake, W.J. (1981) Response to T.B.L. Kirkwood: Bioequivalence Testing—A Need to Rethink. Biometrics, 37, 589-594.
https://doi.org/10.2307/2530573

[18]   Yuen, K.K. and Dixon, W.J. (1973) The Approximate Behavior and Performance of the Two-Sample Trimmed T. Biometrika, 60, 369-374.
https://doi.org/10.1093/biomet/60.2.369

[19]   Yuen, K.K. (1974) The Two-Sample Trimmed T for Unequal Population Variances. Biometrika, 61, 165-170.
https://doi.org/10.1093/biomet/61.1.165

[20]   Beaton, A.E. and Tukey, J.W. (1974) The Fitting of Power Series, Meaning Polynomials, Illustrated on Band-Spectroscopic Data. Technometrics, 16, 147-185.
https://doi.org/10.1080/00401706.1974.10489171

[21]   Yohai, V.J. (1987) High Breakdown-Point and High Efficiency Estimates for Regression. The Annals of Statistics, 15, 642-665.
https://doi.org/10.1214/aos/1176350366

[22]   Koller, M. and Stahel, W.A. (2011) Sharpening Wald-Type Inference in Robust Regression for Small Samples. Computational Statistics & Data Analysis, 55, 2504-2515.
https://doi.org/10.1016/j.csda.2011.02.014

[23]   Low, D.A., Harms, W.B., Mutic, S. and Purdy, J.A. (1998) A Technique for the Quantitative Evaluation of Dose Distributions. Medical Physics, 25, 656-661.
https://doi.org/10.1118/1.598248

[24]   Shende, R., Gupta, G., Patel, G. and Kumar, S. (2016) Commissioning of TrueBeam TM Medical Linear Accelerator: Quantitative and Qualitative Dosimetric Analysis and Comparison of Flattening Filter (FF) and Flattening Filter Free (FFF) Beam. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 5, 51-69.
https://doi.org/10.4236/ijmpcero.2016.51006

[25]   Klein, E.E., Hanley, J., Bayouth, J., Yin, F.F., Simon, W., Dresser, S., et al. (2009) Task Group 142 Report: Quality Assurance of Medical Accelerators. Medical Physics, 36, 4197-4212.
https://doi.org/10.1118/1.3190392

 
 
Top