IJMPCERO  Vol.6 No.2 , May 2017
The Quantification of Intra-Fractional Tumour Motion Errors in Lung Stereotactic Ablative Radiotherapy Patients
Abstract: This work aims at quantifying intra-fractional motion errors and evaluating the appropriateness of a Planning Target Volume (PTV) margin for Queen Elizabeth (QE) Hospital’s patients. Intra-fractional motion errors were quantified for 29 patients who underwent lung Stereotactic Ablative Radiotherapy (SABR) treatment at the cancer centre of QE Hospital. One hundred thirty post-Cone Beam Computed Tomography (CBCT) scans were collected to calculate these errors. In terms of the adequacy of a PTV margin, the intra-fractional motion errors that were calculated are combined with other geometric errors which were taken from historical audit studies. Then, the combined outcome was compared with the common PTV margin that is delineated by most United Kingdom (UK) oncology centres. The findings of this study showed that the systematic component of intra-fractional motion error is equal to 0.08, 0.08 and 0.08 cm in right/left, superior/anterior and anterior/posterior directions, respectively, While the random component of this error is equal to 0.11, 0.13 and 0.14 cm. In addition to that, a PTV margin of 0.5 cm is the appropriate margin for QE Hospital’s patients and this volume is compatible with the common PTV margin that is delineated by the most UK oncology centres. This work concluded that A PTV margin of 0.5 cm is the suitable volume for lung SABR patients at QE Hospital.
Cite this paper: Kanbayti, I. , Ghafoor, Q. , Webster, G. and Jastaniah, S. (2017) The Quantification of Intra-Fractional Tumour Motion Errors in Lung Stereotactic Ablative Radiotherapy Patients. International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 6, 105-110. doi: 10.4236/ijmpcero.2017.62010.

[1]   Xu, F., Wang, J., Bai, S., Li, Y., Shen, Y.L., Zhong, R.M., Jiang, X.Q. and Xu, Q.F. (2008) Detection of Intrafractional Tumour Position Error in Radiotherapy Utilizing Cone Beam Computed Tomography. Radiotherapy and Oncology, 89, 311-319.

[2]   Heijmen, B.J.M. and Stroom, J.C. (2002) Geometrical Uncertainties, Radiotherapy Planning Margins, and the ICRU-62 Report. Radiotherapy and Oncology, 64, 75-83.

[3]   Yan, D., Lockman, D., Martinez, A., Wong, J., Barbbins, D., Vicini, F., Liang, J. and Kestin, L. (2005) Computed Tomography Guided Management of Interfractional Patient Variation. Seminars in Radiation Oncology, 15, 168-179.

[4]   Herk, V.M., Witte, M., Geer, V.J., Schneider, C. and Lebesque, J.V. (2003) Biologic and Physical Fractionation Effects of Random Geometric Errors. International Journal Radiation of Oncology Biology Physics, 57, 1460-1471.

[5]   Guckenberger, M. (2011) Image-Guided Radiotherapy Based on Kilovoltage Cone Beam Computed Tomography—A Review of Technology and Clinical Outcome. European Oncology & Haematology, 7, 121-124.

[6]   Vision, R.T. (2015) Image Guided Radiotherapy and Motion Management.

[7]   Distefano, G., Baker, A., Scott, A.J.D. and Webster, G.J. (2014) Survey of Stereotactic Ablative Radiotherapy in the UK by the QA Group on Behalf of the UK SABR Consortium. British Institute of Radiology, 87, Article Number: 20130681.

[8]   Snoke, J.J., Rossi, M., Wolthaus, J., Herk, V.M., Damen, E. and Belderbos, J. (2009) Frameless Stereotactic Body Radiotherapy for Lung Cancer Using Four-Dimensional Cone Beam CT Guidance. International Journal of Radiation Oncology Biology Physics, 74, 567-574.

[9]   Li, R.J., Han, B., Meng, B., Maxim, P.G., Xing, L., Koong, A.C., Diehn, M. and Loo, B.W. (2013) Clinical Implementation of Intra-Fraction Cone Beam Computed Tomography Imaging during Lung Tumor Stereotactic Ablative Radiation Therapy. International Journal of Radiation Oncology Biology Physics, 87, 917-923.

[10]   Yin, W.J., Sun, Y., Chi, F., Fang, J.L., Guo, R., Yu, X.L., Mao, Y.P., Qi, Z.Y., Guo, Y., Liu, M.Z. and Ma, J. (2013) Evaluation of Inter-Fraction and Intra-Fraction Errors during VMAT in Nasopharyngeal Carcinoma Patients. Radiation Oncology, 8, 78.

[11]   Takahashi, W., Yamashita, H., Kida, S., Masutani, Y., Sakumi, A., Ohtomo, K., Nakagawa, K. and Haga, A. (2013) Verification of Planning Target Volume Settings in Volumetric Modulated Arc Therapy for Stereotactic Body Radiation Therapy by Using in-Treatment 4-Dimensional Cone Beam Computed Tomography. International Journal of Radiation Oncology Biology Physics, 86, 426-431.