Back
 JCPT  Vol.7 No.2 , April 2017
Direct Process to Prepare Crystallized Freestanding Membranes of Hydroxyapatite Using Sacrificial Layer of Barium-Compounds
Abstract: Freestanding membrane (FSM) of hydroxyapatite (HA) is a thin sheet of pure HA without any supporting substrates. Our original preparation process of FSM of HA had three steps: The first was the deposition of HA layer on sacrificial layer of solvent-soluble materials, the second was separation of FSM of HA by means of dissolution of sacrificial layer, and the third was post-annealing to crystallize FSM of HA. To date, the post-annealing process was a serious bottleneck of productivity owing to its too long time. In this short report, we proposed a novel sacrificial layer, heatproof and water-soluble Ba-compound, which makes the direct deposition of crystallized HA possible due to its heatproof property because the problem on the original process was that the previous sacrificial layers have no heatproof property and HA layer should be deposited as amorphous. We can deposit the Ba-compound sacrificial layer only in 1 hour followed with the direct deposition of crystallized HA layer, substituting the 20 hours of post-annealing. The FSM of HA was separated successfully from the substrate by means of dissolution of Ba-compound with water. Our novel process can shrink the process time by 19 hours.
Cite this paper: Nishikawa, H. and Nishii, T. (2017) Direct Process to Prepare Crystallized Freestanding Membranes of Hydroxyapatite Using Sacrificial Layer of Barium-Compounds. Journal of Crystallization Process and Technology, 7, 48-53. doi: 10.4236/jcpt.2017.72003.
References

[1]   Leukers, B., Gulkan, H., Irsen, S.H., Milz, S., Tille, C., Schieker, M. and Seitz, H. (2005) Hydroxyapatite Scaffolds for Bone Tissue Engineering Made by 3D Printing. Journal of Materials Science: Materials in Medicine, 16, 1121-1124.
http://dx.doi.org/10.1007/s10856-005-4716-5

[2]   Nishikawa, H., Hatanaka, R., Kusunoki, M., Hayami, T. and Hontsu, S. (2008) Preparation of Freestanding Hydroxyapatite Membranes with Excellent Biocompatibility and Flexibility. Applied Physics Express, 1, 088001.
http://dx.doi.org/10.1143/APEX.1.088001

[3]   Kusunoki, M., Kawakami, Y., Matsuda, T., Nishikawa, H., Hayami, T. and Hontsu, S. (2010) Fabrication of a Large Hydroxyapatite Sheet. Applied Physics Express, 3, 107003.
http://dx.doi.org/10.1143/APEX.3.107003

[4]   Hontsu, S., Yoshikawa, K., Kato, N., Kawakami, Y., Hayami, T., Nishikawa, H., Kusunoki, M. and Yamamoto, K. (2011) Restoration and Conservation of Dental Enamel using a Flexible Apatite Sheet. Journal of the Australian Ceramic Society, 47, 11-13.

[5]   Hontsu, S., Kato, N., Yamamoto, E., Nishikawa, H., Kusunoki, M., Hayami, T. and Yoshikawa, K. (2011) Regeneration of Tooth Enamel by Flexible Hydroxyapatite Sheet. Key Engineering Materials, 493-494, 615-619.
http://dx.doi.org/10.4028/www.scientific.net/KEM.493-494.615

[6]   Yamamoto, E., Kato, N., Nishikawa, H., Kusunoki, M., Hayami, T., Yoshikawa, K. and Hontsu, S. (2012) Adhesive Strength between Flexible Hydroxyapatite Sheet and Tooth Enamel. Key Engineering Materials, 529-530, 522-525.
http://dx.doi.org/10.4028/www.scientific.net/KEM.529-530.522

[7]   Kusunoki, M., Matsuda, T., Fujita, N., Sakoishi, Y., Iguchi, R., Hontsu, S., Nishikawa, H. and Hayami, T. (2013) Control of Crystallinity of Hydroxyapatite Sheet. Key Engineering Materials, 583, 47-50.
http://dx.doi.org/10.4028/www.scientific.net/KEM.583.47

[8]   Kato, N., Isai, A., Yamamoto, E., Nishikawa, H., Kusunoki, M., Yoshikawa, K., Yasuo, K., Yamamoto, K. and Hontsu, S. (2015) Evaluation of Dentin Tubule Sealing Rate Improved by Attaching Ultrathin Amorphous Calcium Phosphate Sheet. Key Engineering Materials, 631, 258-261.
http://dx.doi.org/10.4028/www.scientific.net/KEM.631.258

[9]   Hashimoto, Y. Nishikawa, H., Kusunoki, M., Li, P.Q. and Hontsu, S. (2015) A Novel Membrane-type Apatite Scaffold Engineered by Pulsed Laser Ablation. Dental Materials Journal, 34, 345-350.
http://dx.doi.org/10.4012/dmj.2014-299

 
 
Top