Back
 CM  Vol.2 No.3 , September 2011
The Effect of Aqueous Extract of Cecropia glazioui Snethlage (Embauba) in the Rat Fetal Development
Abstract: The effect of aqueous extract of Cecropia glazioui Snethlage (Embauba) in the rat fetal development. This study was to complement previous assays on the physical and neurobehavioral development of rats resulted from oral administration of 1 g/kg/day Cecropia glazioui Snethlage (C. glazioui) aqueous extract (LD50 > 5 g·kg-1in pregnant rats (peri- and post-natal studies). In the present study, the effect of 2.5 g/kg/week C. glazioui aqueous extract, administered to pregnant rats during 15 days, was verified in the rat offspring development. No acute or chronic toxicity (no effects on mortality or weight average daily gain) were observed. In addition, no effects on reproductive parameters (offspring vitality, placenta and fetus weight, number of corpora lutea on each ovary, pre- and post-implantation loss) and on offspring external morphology were found. We concluded that C. glazioui aqueous extract administered during pregnancy did not cause abnormalities in rat offspring.
Cite this paper: nullP. Randazzo-Moura, M. Silva, Y. Oshima-Franco, F. Groppo and M. Gerenutti, "The Effect of Aqueous Extract of Cecropia glazioui Snethlage (Embauba) in the Rat Fetal Development," Chinese Medicine, Vol. 2 No. 3, 2011, pp. 115-119. doi: 10.4236/cm.2011.23019.
References

[1]   F. F. Rocha, A. J. Lapa and T. C. de Lima, “Evaluation of the Anxiolytic-Like Effects of Cecropia glazioui Sneth in Mice,” Pharmacology, Biochemistry and Behavior, Vol. 71, No. 1-2, 2002, pp. 183-190. doi:10.1016/S0091-3057(01)00695-5

[2]   F. F. Rocha, M. T. Lima-Landman, M. M. Tanae, T. C. de Lima and A. J. Lapa, “Antidepressant-Like Effect of Cecropia glazioui Sneth and Its Constituents―In Vivo and in Vitro Characterization of the Underlying Mechanism,” Phytomedicine, Vol. 14, No. 6, 2007, pp. 396-402. doi:10.1016/j.phymed.2007.03.011

[3]   S. Delarcina, M. T. Lima-Landman, C. Souccar, R. M. Cysneiros, M. M. Tanae and A. J. Lapa, “Inhibition of Histamine-Induced Bronchospasm in Guinea Pigs Treated with Cecropia glaziovi Sneth and Correlation with the in Vitro Activity in Tracheal Muscles,” Phytomedicine, Vol. 14, No. 5, 2007, pp. 328-332. doi:10.1016/j.phymed.2006.12.022

[4]   M. T. Lima-Landman, A. C. Borges, R. M. Cysneiros, T. C. de Lima, C. Souccar and A. J. Lapa, “Antihypertensive Effect of a Standardized Aqueous Extract of Cecropia glaziovii Sneth in Rats: An in Vivo Approach to the Hypotensive Mechanism,” Phytomedicine, Vol. 14, No. 5, 2007, pp. 314-320. doi:10.1016/j.phymed.2007.03.003

[5]   M. F. Ninahuaman, C. Souccar, A. J. Lapa and M. T. Lima-Landman, “ACE Activity during the Hypotension Produced by Standardized Aqueous Extract of Cecropia glaziovii Sneth: A Comparative Study to Captopril Effects in Rats,” Phytomedicine, Vol. 14, No. 5, 2007, pp. 321-327. doi:10.1016/j.phymed.2006.12.010

[6]   C. Souccar, R. M. Cysneiros, M. M. Tanae, L. M. Torres, M. T. Lima-Landman and A. J. Lapa, “Inhibition of Gastric Acid Secretion by a Standardization Aqueous Extract of Cecropia glaziovii Sneth and Underlying Mechanism,” Phytomedicine, Vol. 15, No. 6-7, 2008, pp. 462-469. doi:10.1016/j.phymed.2008.02.006

[7]   R. Lewontin, “It Ain’t Necessarily So—The Dream of the Human Genome and Other Illusions,” New York Review Books, New York, 2000.

[8]   M. Wink, “Physiology of Secondary Product Formation in Plants,” In: B. V. Charwood and M. J. C. Rhodes, Eds., Secondary Products from Plant Tissue Culture, Clarendon, Oxford, 1990, pp. 67-86.

[9]   M. M. Tanae, M. T. Lima-Landman, T. C. de Lima, C. Souccar and A. J. Lapa, “Chemical Standardization of the Aqueous Extract of Cecropia glaziovii Sneth Endowed with Antihypertensive, Brochodilator, Antiacid Secretion and Antidepressant-Like Activities,” Phytomedicine, Vol. 14, No. 5, 2007, pp. 309-313. doi:10.1016/j.phymed.2007.03.002

[10]   Brasil, Ministério da Saúde, Agência Nacional de Vigilancia Sanitária, Resolu??o de Diretoria Colegiada 48, Diário Oficial da Uni?o, Brasília, 2004.

[11]   Brasil, Ministério da Saúde, Agência Nacional de Vigilancia Sanitária, Resolu??o 88, Diário Oficial da Uni?o, Brasília, 2004.

[12]   Brasil, Ministério da Saúde, Agência Nacional de Vigilancia Sanitária, Resolu??o 89, Diário Oficial da Uni?o, Brasília, 2004.

[13]   Brasil, Ministério da Saúde, Agência Nacional de Vigilancia Sanitária, Resolu??o 90, Diário Oficial da Uni?o, Brasília, 2004.

[14]   Brasil, Ministério da Saúde, Agência Nacional de Vigilancia Sanitária, Resolu??o 91, Diário Oficial da Uni?o, Brasília, 2004.

[15]   Brasil, Presidência da República, Decreto 5813, Diário Oficial da Uni?o, Brasília, 2006.

[16]   M. Gerenutti, A. F. Prestes, M. G. Silva, F. de S. Del Fiol, Y. O. Franco, P. C. Venancio and F. C. Groppo, “The Effect of Cecropia glazioui Snethlage on the Physical and Neurobehavioral Development of Rats,” Pharmazie, Vol. 63, No. 5, 2008, pp. 398-404.

[17]   B. H. Vickery and J. P. Bennett, “Rats and Mice,” In: E. S. E. Hafez, Ed., Reproduction and Breeding Techniques for Laboratory Animals, Lea & Febiger, Philadelphia, 1970, pp. 299-315.

[18]   K. A. Keller, “Developmental and Reproductive Toxicology,” In: D. Jacobson-Kram and K. A. Keller, Eds., Toxicology Testing Handbook: Principles, Applications and Data Interpretation, Marcel Dekker, Inc., New York, 2001, pp. 195-254.

[19]   M. Gerenutti, A. H. de-Souza Spinosa and M. M. Bernardi, “Effects of Bracken Fern (Pteridium aquilinum L. Kuhn) Feeding during the Development of Female Rats and Their Offspring,” Veterinary and Human Toxicology, Vol. 34, No. 4, 1992, pp. 307-310.

[20]   M. Gerenutti, F. Del Fiol and F. C. Groppo, “Reproductive Performance of Pregnant Rats and Embryotoxic Effects of Ciprofloxacin,” Pharmazie, Vol. 61, No. 1, 2006, pp. 79-80.

[21]   W. F. Rayburn, H. D. Christensen and C. L. Gonzalez, “Effect of Antenatal Exposure to Saint John’s Wort (Hypericum) on Neurobehavior of Developing Mice,” American Journal of Obstetrics and Gynecology, Vol. 183, No. 5, 2000, pp. 1225-1231. doi:10.1067/mob.2000.108889

[22]   US EPA, “Guidelines for the Health Assessment of Suspected Developmental Toxicants,” Federal Register 51:34028, 1986; Proposed Amendments Federal Register 54:9386, 1989.

 
 
Top