SS  Vol.2 No.7 , September 2011
Seasonal Frequency in Esophageal Atresia/Tracheo-Esophageal Fistula: Is there an Environmental Etiology?
Background: Esophageal Atresia and Tracheo-Esophageal Fistula (EA/TEF) occurs sporadically and its eti-ology is poorly understood. We observed six cases of EA/TEF within three weeks of October 2007 at the Lagos University Teaching Hospital (LUTH), Nigeria. Aims: To analyze the monthly trends of presentation of EA/TEF at the LUTH from 2002-7, test the hypothesis that the October figures were not due to chance and correlate data with known local disease patterns. Setting: Lagos University Teaching Hospital, Nigeria. Patients, Materials, Method: A retrospective analysis of all EA/TEFs managed at the LUTH within stated period. Results: 25 babies with EA/TEF presented over the period. 10 (40%) were seen in the month of Oc-tober, 5 (20%) occurred in May while the rest were spread over the rest of the months. Chi-square analysis confirmed that the EA/TEF cases occurred significantly more frequently in October (P < 0.001) and this ob-servation was unlikely due to chance. Conclusions: There seems to be a seasonal variation in the occurrence of EA/TEF in Lagos, with a significantly higher frequency in the month of October. 96% of mothers of ba-bies with EA/TEF lived in low socioeconomic parts of Lagos. This study highlights the possibility of local viral etiology of EA/TEF.

Cite this paper
nullC. Bode, A. Ademuyiwa and S. Ikhisemojie, "Seasonal Frequency in Esophageal Atresia/Tracheo-Esophageal Fistula: Is there an Environmental Etiology?," Surgical Science, Vol. 2 No. 7, 2011, pp. 385-387. doi: 10.4236/ss.2011.27084.

[1]   J. F. Felix, M. F. van Dooren, M. Klaasens, W. C. Hop, C. P. Torfs, et al., “Environmental Factors in the Etiology of Esophageal Atresia and Congenital Diaphragmatic Hernia: Results of a Case-Controlled Study,” Birth Defects Research. Part A, Clinical and Molecular Teratology, Vol. 82, No. 2, 2008, pp. 98-105. doi:10.1002/bdra.20423

[2]   C. Fraser, P. A. Baird and A. D. Sadovnick, “A Comparison of Incidence Trends for Esophageal Atresia and Tracheoesophageal Fistula, and Infectious Disease,” Teratology, Vol. 36, No. 3, 1987, pp. 363-369.

[3]   M. Van Staey, S. De Bies, M. T. Matton and J. De Roose, “Familial Congenital Esophageal Atresia. Personal Case Report and Review of the Literature,” Human Genetics, Vol. 66, No. 2-3, 1984, pp. 260-266.

[4]   C. O. Bode, “Presentation and Management Outcome of Intussusceptions in Lagos: A Prospective Study,” African Journal of Paediatric Surgery, Vol. 5, No. 1, 2008, pp. 24-28.

[5]   C. O. Bode and S. A. Omilabu, “Viral Isolates of Intussusceptions in Nigerian Infants,” South African Journal of Surgery, Vol. 40, No. 2, 2002, pp. 57-58.

[6]   O. D. Olaleye, S. A. Omilabu, A. O. Olabode and A. H. Fagbami, “Serological Evidence for Influenza Virus Activity in Nigeria (1985-1987),” Virologie, Vol. 40, No. 1, 1989, pp. 11-17.

[7]   A. Dessanti, G. Massarelli, M. T. Piga, A. Porcu and G. Dettori, “Biliary, Anorectal and Esophageal Atresia: A New Entity?” Tohoku Journal of Experimental Medicine, Vol. 181, No. 1, 1997, pp. 49-55. doi:10.1620/tjem.181.49

[8]   C. D. Ozimeck, R. C. Grimson and A. S. Aylsworth, “AN Epidemiologic Study of Tracheoesophageal Fistula and Esophageal Atresia in North Carolina,” Teratology, Vol. 25, No. 1, 1982, pp. 53-59.