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 JBM  Vol.5 No.3 , March 2017
Nrf-2 and HO-1 Expression in Medulloblastoma: A Clinicopathological Analysis
Abstract:
Medulloblastoma (MB) is one of the most common malignant tumors with poor survival in children. Nuclear factor erythroid 2-related factor2 (Nrf-2) and heme oxygenase-1 (HO-1) have been considered to play major roles in the pathogenesis of many tumors. There is no report about clinicopathological significance of Nrf-2 and HO-1 expression in medulloblastoma. In the present study, to explore the expression and potential function of Nrf-2 and HO-1 in MBs, immunohistochemistry was used to examine the Nrf-2 and HO-1 expression in 41 MBs and 27 control tissues adjacent to the tumor. The results showed that in the cases of MB, the positive expression rates of Nrf-2 and HO-1 (82.9% and 78.0%) were significantly increased compared with that (37.0% and 29.6%) in peritumoral control brain tissues. The difference was statistically significant (P < 0.001). A positive correlation between the expression of Nrf-2 and HO-1 in MB (r = 0.542, P < 0.05) was observed. However, there was no definite correlation among the expression of Nrf-2 and HO-1 and the clinical pathological features (P > 0.05). The abnormal expression of Nrf-2 and HO-1 in MB suggest that the Nrf-2/HO-1 pathway plays an important role in the formation and development of MB and may be a potential therapeutic target for MB.
Cite this paper: Tang, L. , Deng, Y. , Gao, M. , Lin, X. , Zhu, J. and Li, Y. (2017) Nrf-2 and HO-1 Expression in Medulloblastoma: A Clinicopathological Analysis. Journal of Biosciences and Medicines, 5, 142-147. doi: 10.4236/jbm.2017.53015.
References

[1]   [1] El-Sheikh, A., Fan, R., Birks, D., et al. (2010) Inhibition of Aurora Kinase A Enhances Chemosensitivity of Medulloblastoma Cell Lines. Pediatr Blood Cancer, 55, 35-41.

[2]   Raso, A., Mascelfi, S., Biassoni, R., et a1. (2011) High Levels of PROM 1(CD133) Transcript Are a Potential Predictor of Poor Prognosis in Medul-loblastoma. Neuro Oncol, 13, 500-508. https://doi.org/10.1093/neuonc/nor022

[3]   Joshi, G. and Johnson, J.A. (2012) The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurode-generative Diseases. Recent Pat CNS Drug Discov., 7, 218-229. https://doi.org/10.2174/157488912803252023

[4]   Gan, L. and Johnson, J.A. (2014) Oxidative Damage and the Nrf2-ARE Pathway in Neurodegenerative Diseases. Bio-chim Biophys Acta., 1842, 1208-1218. https://doi.org/10.1016/j.bbadis.2013.12.011

[5]   Yang, H., Wang, W., Zhang, Y., et al. (2011) The Role of NF-E2-Related Factor 2 in Predicting Chemoresistance and Prognosis in Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer, 12, 166-171. https://doi.org/10.1016/j.cllc.2011.03.012

[6]   Taguchi, K., Motohashi, H. and Yamamoto, M. (2011) Molecular Mechanisms of the Keap1-Nrf2 Pathway in Stress Response and Cancer Evolution. Genes to Cells, 16, 123-140. https://doi.org/10.1111/j.1365-2443.2010.01473.x

[7]   Chi, P.L., Liu, C.J., Lee, I.T., et al. (2014) HO-1 Induction by CO-RM2 Attenuates TNF-α-Induced Cytosolic Phospholipase A2 Expression via Inhibition of PKCα- Dependent NADPH Oxi-dase/ROS and NF-κB. Mediators Inflamm., 2014, 279171. https://doi.org/10.1155/2014/279171

[8]   Jozkowicz, A., Was, H. and Dulak, J. (2007) Heme Oxygenase-1 in Tumors: Is It a False Friend? Antioxid Redox Signal, 9, 2099-2117. https://doi.org/10.1089/ars.2007.1659

[9]   Fang, J., Akaike, T. and Maeda, H. (2004) Antiapoptotic Role of Heme Oxygenase (HO) and the Potential of HO as a Target in Anticancer Treatment. Apoptosis, 9. 27-35. https://doi.org/10.1023/B:APPT.0000012119.83734.4e

[10]   Kinobe, R.T., Dercho, R.A. and Nakatsu, K. (2008) Inhibitors of the Heme Oxygenase-Carbon Monoxide System: On the Doorstep of the Clinic? Can J Physiol Pharmacol., 86, 577-599. https://doi.org/10.1139/Y08-066

 
 
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