JBM  Vol.5 No.3 , March 2017
Nrf-2 and HO-1 Expression in Medulloblastoma: A Clinicopathological Analysis
Medulloblastoma (MB) is one of the most common malignant tumors with poor survival in children. Nuclear factor erythroid 2-related factor2 (Nrf-2) and heme oxygenase-1 (HO-1) have been considered to play major roles in the pathogenesis of many tumors. There is no report about clinicopathological significance of Nrf-2 and HO-1 expression in medulloblastoma. In the present study, to explore the expression and potential function of Nrf-2 and HO-1 in MBs, immunohistochemistry was used to examine the Nrf-2 and HO-1 expression in 41 MBs and 27 control tissues adjacent to the tumor. The results showed that in the cases of MB, the positive expression rates of Nrf-2 and HO-1 (82.9% and 78.0%) were significantly increased compared with that (37.0% and 29.6%) in peritumoral control brain tissues. The difference was statistically significant (P < 0.001). A positive correlation between the expression of Nrf-2 and HO-1 in MB (r = 0.542, P < 0.05) was observed. However, there was no definite correlation among the expression of Nrf-2 and HO-1 and the clinical pathological features (P > 0.05). The abnormal expression of Nrf-2 and HO-1 in MB suggest that the Nrf-2/HO-1 pathway plays an important role in the formation and development of MB and may be a potential therapeutic target for MB.
Cite this paper: Tang, L. , Deng, Y. , Gao, M. , Lin, X. , Zhu, J. and Li, Y. (2017) Nrf-2 and HO-1 Expression in Medulloblastoma: A Clinicopathological Analysis. Journal of Biosciences and Medicines, 5, 142-147. doi: 10.4236/jbm.2017.53015.

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