Health  Vol.9 No.3 , March 2017
Effects of Antihypertensive Drugs on Skin Blood Flow as an Indicator of Sympathetic Responses to Mental Stress in Hypertensive Patients
Abstract: The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. The Stroop color-word conflict test was applied as a mental stress test and hemodynamic responses to mental stress were measured, including blood pressure, pulse rate, and skin blood flow. Elevation of blood pressure by mental stress was suppressed in the combination therapy group compared with the calcium antagonist group. Reduction of skin blood flow by mental stress was suppressed in both the angiotensin II blocker group and the combination therapy group compared with the calcium antagonist group. In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress.
Cite this paper: Shinya, H. , Iwane, N. and Hano, T. (2017) Effects of Antihypertensive Drugs on Skin Blood Flow as an Indicator of Sympathetic Responses to Mental Stress in Hypertensive Patients. Health, 9, 568-575. doi: 10.4236/health.2017.93040.

[1]   Nishimura, T., Nishio, I., Ohtani, H., Jimbo, S., Kuchii, M. and Masuyama, Y. (1979) Plasma Catecholamines Determination Using High Pressure Liquid Chromatography and Their Roles in Blood Pressure Regulation and Experimental Hypertension in Rats. Japanese Circulation Journal, 43, 855-865.

[2]   Mizukoshi, M., Hano, T., Kuchii, M., Nishio, I. and Masuyama, Y. (1985) Plasma Noradrenaline and Its Deaminated Metabolites in Essential Hypertension and Pheochromocytoma. Japanese Circulation Journal, 49, 1035-1042.

[3]   Sakuragi, T., Okamoto, I., Fujiki, T. and Dan, K. (1996) Skin Blood Flow and Plasma Catechol Amines during Removal of Pheochromocytoma. Anesthesiology, 85, 1485-1488.

[4]   Yamamoto, K., Sobue, G., Iwase, S., Nagamatsu, M., Mano, T. and Mitsuma, T. (1997) Skin Sympathetic Nerve Activity in Guillain-Barre Syndrome: A Microneurographic Study. Journal of Neurology, Neurosurgery, and Psychiatry, 63, 537-541.

[5]   Koskinen, L.O.D. and Blomstedt, P. (2008) Sympathicotomy Affects Cutaneous Blood Flow, Temperature, and Sympathicus-Mediated Reflexes. Acta Neurologica Scandinavica, 118, 402-406.

[6]   Hoshikawa, Y. and Yamamoto, Y. (1997) Effects of Stroop Color-Word Conflict Test on the Autonomic Nervous System Response. American Journal of Physiology, 272, H1113-H1121.

[7]   Ferguson, D.W. and Hayes, D.W. (1989) Nifedipine Potentiates Cardiopulmonary Baroreflex Control of Sympathetic Nerve Activity in Healthy Humans. Direct Evidence from Micro Neurographic Studies. Circulation, 80, 285-298.

[8]   Heesch, C.M., Miller, B.M., Thames, M.D. and Abboud, F.M. (1983) Effects of Calcium Channel Blockers on Isolated Carotid Baroreceptors and Baroreflex. American Journal of Physiology, 245, H653-H661.

[9]   Grassi, G., Spaziani, D., Serevalle, G., Bertinieri, G., Dell’Oro, R., Cuspidi, C. and Mancia, G. (1999) Effects of Amlodipine on Sympathetic Nerve Traffic and Baroreflex Control of Circulation in Heart Failure. Hypertension, 33, 671-675.

[10]   Niederberger, M., Aubert, J., Nussberger, J., Brunner, H.R. and Waeber, B. (1995) Sympathetic Nerve Activity in Conscious Renal Hypertensive Rats Treated with an Angiotensin Converting Enzyme Inhibitor or an Angiotensin II Antagonist. Journal of Hypertension, 13, 439-445.

[11]   Kasama, S., Toyama, T., Kumakura, H., Takayama, Y., Ichikawa, S., Suzuki, T. and Kurabayashi, M. (2005) Effects of Candesartan on Cardiac Sympathetic Nerve Activity in Patients with Congestive Heart Failure and Preserved Left Ventricular Ejection Fraction. Journal of the American College of Cardiology, 45, 661-667.

[12]   Wallin, B.G. and Charkoudian, N. (2007) Sympathetic Neural Control of Integrated Cardiovascular Function: Insights from Measurement of Human Sympathetic Nerve Activity. Muscle Nerve, 36, 595-614.