IJCM  Vol.8 No.3 , March 2017
The Effect of Pomegranate Paste on Neonatal Jaundice Incidence: A Clinical Trial in Women during Pregnancy
Abstract: Purpose: Some topics such as women’s life and nutrition and using some special medicines during pregnancy have been discussed and demonstrated as effective factors on infant’ health. Based on recommendations in Iranian traditional medicine, we aimed to evaluate the efficacy of pomegranate paste consumed by women during their pregnancy on the neonatal jaundice incidence. Methods: In this single-blinded controlled clinical trial, 80 healthy pregnant women were randomly divided into 2 groups, as treatment and control. The treatment group members added pomegranate paste to their daily diet from the 34th week of the pregnancy to birth, as administered. The levels of neonates’ bilirubin were checked in the 5th day of the delivery. Results: Both the need of phototherapy and the mean level of neonates’ bilirubin in the group fed with pomegranate paste were significantly lesser compared to control group. The number of neonates who were undergone phototherapy in the pomegranate paste receiving group was significantly lesser than that in the control group (P value = 0.029). By measuring the total bilirubin, statically significant difference between the treatment group and the control group was seen (P value = 0.021). Conclusion: The results of this study suggest the possible effect of adding pomegranate paste to pregnant women’s diet on the incidence of neonatal jaundice.
Cite this paper: Manouchehrian, M. , Shakiba, M. , Shariat, M. , Hassan Lotfi, M. , Kamalinejad, M. and Babaeian, M. (2017) The Effect of Pomegranate Paste on Neonatal Jaundice Incidence: A Clinical Trial in Women during Pregnancy. International Journal of Clinical Medicine, 8, 144-151. doi: 10.4236/ijcm.2017.83014.

[1]   Stoll, B. and Kliegman, R. (2008) Jaundice and Hyperbilirubinemia in the Newborn. In: Behemen, R., Kliegman, R. and Jenson, H., Eds., Nelson Textbook of Pediatrics, 18th Edition, Saunders, Philadelphia, 756-765.

[2]   Azadbakht, M., Pishva, N., Mohammadi Samani, S. and Alinejad, F. (2005) The Effect of Purgative Manna on the Infant Jaundice. Iranian Journal of Pharmaceutical Sciences, 1, 95-100.

[3]   Ambalavanan, N. and Carloa, W.A. (2015) Kernicterus. In: Kliegman, R.M., Stanton, B.F., Schor, N.F. and St Geme, J.W., Eds., Nelson Textbook of Peadiatrics, 20th Edition, Elseviers, New Delhi, 876.

[4]   Bhutani, V.K., Poland, R., Meloy, L.D., Hegyi, T., Fanaroff, A.A. and Maisels, M.J. (2016) Clinical Trial of Tin Mesoporphyrin to Prevent Neonatal Hyperbilirubinemia. Journal of Perinatology, 36, 533-539.

[5]   Davies, G.A., Maxwell, C., McLeod, L., et al. (2010) Obesity in Pregnancy. International Journal of Gynecology & Obstetrics, 110, 167-173.

[6]   Basiri-Moghadam, M., Basiri-Moghadam, K., Kianmehr, M. and Jani, S. (2015) The Effect of Massage on Neonatal Jaundice in Stable Preterm Newborn Infants: A Randomized Controlled Trial. Journal of Pakistan Medical Association, 65, 602-606.

[7]   Fok, T.F. (2001) Neonatal Jaundice-Traditional Chinese Medicine Approach. Journal of Perinatology, 21, S98-S100.

[8]   Ebrahimimd, S., Ashkani-Esfahani, S. and Poormahmudibs, A. (2011) Investigating the Efficacy of Zizyphus jujuba on Neonatal Jaundice. Iranian Journal of Pediatrics, 21, 320-324.

[9]   Dennery, P.A. (2002) Pharmacological Interventions for the Treatment of Neonatal Jaundice. Seminars in Neonatology, 7, 111-119.

[10]   Aghili Khorasani, M.H. (2001) Makhzanul-Advieh (Encyclopedia of Ancient medical Drugs). Choogan, Tehran.

[11]   Kermani, N.A. (2008) Sharhol-Asbab val Alamat. Almoa, Tehran.

[12]   Hosseini, M.M. (1979) Tohfeye Hakim Momen. Mahmoudi, Tehran.

[13]   Ernst, E. (2002) Herbal Medicinal Products during Pregnancy: Are They Safe? BJOG, 109, 227-235.

[14]   Montvale, J., Brendler, T. and Jaenicke, C. (2000) PDR for Herbal Medicines. Medical Economics Company, Montvale.

[15]   Mousavinejad, G., Emam-Djomeh, Z., Rezaei, K. and Khodaparast, M.H.H. (2009) Identification and Quantification of Phenolic Compounds and Their Effects on Anti-oxidant Activity in Pomegranate Juices of Eight Iranian Cultivars. Food Chemistry, 115, 1274-1278.

[16]   Muzaffar, K., Dinkarrao, B.V. and Kumar, P. (2016) Optimization of Spray Drying Conditions for Production of Quality Pomegranate Juice Powder. Cogent Food & Agriculture, 2, Article ID: 1127583.

[17]   Yildiz, H., Bozkurt, H. and Icier, F. (2009) Ohmic and Conventional Heating of Pomegranate Juice: Effects on Rheology, Color, and Total Phenolics. Food Science and Technology International, 15, 503-512.

[18]   Tabatabaei, M.H. (1996) Almizan Fi Tafsir Al-Quran. Translated by Mussavi, M.B., The Office of Qum Hawze Ilmieh Teachers’ Society, Vol. 16, 313-415.

[19]   Miguel, M.G., Neves, M.A. and Antunes, M.D. (2010) Pomegranate (Punica granatum L.): A Medicinal Plant with Myriad Biological Properties—A Short Review. Journal of Medicinal Plants Research, 4, 2836-2847.

[20]   Dabaghian, F.H., Kamalinejad, M., Shojaei, A. and Fard, M.A. (2012) Presenting Anti-Diabetic Plants in Iranian Traditional Medicine. Journal of Diabetes and Endocrinology, 3, 70-76.

[21]   Tavakkoli-Kakhki, M., Motavasselian, M., Mosaddegh, M., et al. (2014) Omega-3 and Omega-6 Content of Medicinal Foods for Depressed Patients: Implications from the Iranian Traditional Medicine. Avicenna Journal of Phytomedicine, 4, 225-230.

[22]   Dastjerdi, E.V., Abdolazimi, Z., Ghazanfarian, M., Amdjadi, P., Kamalinejad, M. and Mahboubi, A. (2014) Effect of Punica granatum L. Flower Water Extract on Five Common Oral Bacteria and Bacterial Biofilm Formation on Orthodontic Wire. Iranian Journal of Public Health, 43, 1688-1694.

[23]   Kamali, M., Khodadoost, M., Tavakoli, H., et al. (2016) The Role of Syndrome Differentiation in the Clinical Efficacy of Punica granatum on Patients with Ulcerative Colitis. Iranian Journal of Medical Sciences, 41, S15.

[24]   Pantuck, A.J., Leppert, J.T., Zomorodian, N., et al. (2006) Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen Following Surgery or Radiation for Prostate Cancer. Clinical Cancer Research, 12, 4018-4026.

[25]   Jurenka, J. (2008) Therapeutic Applications of Pomegranate (Punica granatum L.): A Review. Alternative Medicine Review, 13, 128-144.

[26]   Chen, B., Longtine, M.S. and Nelson, D.M. (2013) Punicalagin, a Polyphenol in Pomegranate Juice, Downregulates p53 and Attenuates Hypoxia-Induced Apoptosis in Cultured Human Placental Syncytiotrophoblasts. American Journal of Physiology-Endocrinology and Metabolism, 305, E1274-E1280.

[27]   Aghili Khorasani, M.H. (2008) Kholastol Hekmat. RICM, Qom.