Back
 JBM  Vol.5 No.3 , March 2017
The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma
Xiao Lin1, Yu Li1,2,3*
Abstract:
Medulloblastoma (MB) is common tumor of the central nervous system in children. It’s reported that PI3K/AKT and Wnt signal pathway have important roles in MB. This study aims to investigate the expression of PI3K, AKT, Β-catenin and VEGFR-2 in MB to find a new pathway for MB. A total of 33 MB and 17 control brain cases were retrospectively evaluate d for PI3K, AKT, β-catenin and VEGFR-2 expression by immunohistochemical staining, and the relationship with clinical feature were analyzed. The positive rate of PI3K, AKT, β-catenin and VEGFR-2 in 33 MB were significantly greater than those in control group (P < 0.05), and significant positive correlation was found between PI3K, AKT, β-catenin and VEGFR-2 each other in MB (P < 0.05). Moreover, the clinical data, such as age, gender, tumor size was no significant correlation between the expression of PI3K, AKT, β-catenin and VEGFR-2 was found (P < 0.05).
Cite this paper: Lin, X. , Li, Y. , (2017) The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma. Journal of Biosciences and Medicines, 5, 32-38. doi: 10.4236/jbm.2017.53004.
References

[1]   Xue, G., Restuccia, D.F., Lan, Q., et al. (2012) Promotes Tumor Metastasis via Mediating Cross-Talk between PI3K/Akt and TGF-β Signaling Axes. Cancer Discov, 2, 248-259. https://doi.org/10.1158/2159-8290.CD-11-0270

[2]   Liao, H., Zhou, Q., Gu, Y., et al. (2012) Ovarian Epithelian Tumor Cells and Metformin Inhibits the Effect through the Mtor Signaling Pathway. Oncol Rep, 27, 1873-1878.

[3]   Yip, W.K. and Seow, H.F. (2012) Signaling by EGF Downregulates Membranous E-Cadherin and β-Catenin and Enhances Invasion in Nasopharyngeal Carcinoma Cells. Cancer Lett, 318, 162-172. https://doi.org/10.1016/j.canlet.2011.12.018

[4]   Or, Y.Y., Hui, A.B., Tam, K.Y., et al. (2005) Characterization of Chromosome 3q and 12q Amplicons in Nasopharyngeal Carcinoma Cell Line. Int J Oncol, 26, 49-56.

[5]   Knobbe, C.B., Kieslich, A.T. and Reifenberger, G. (2005) Genetic Alteration and Expression of the Phosphoinositol-3-Kinase/AKT Pathway Gene PIK3CA and PIKE in Human Gliobblastomas. Neuropathol Appl Neurpbiol, 31, 486-490. https://doi.org/10.1111/j.1365-2990.2005.00660.x

[6]   Louis, D.N., Ohgaki, H., Wiestler, O.D., et al. (2007) The 2007 WHO Classification of Tumours of the Central Nervous System. Acta Neurpathol, 114, 97-109. https://doi.org/10.1007/s00401-007-0243-4

[7]   Liao, S.J., Yuan, B., Hu, X.J., et al. (2008) The Expression of PDK/AKT/P-AKT and the Correlation with Ki67 in Cervical Cancer. Tumor, 28, 317-321.

[8]   Morrison, J.A., Gulley, M.L., Pathmanathan, R., et al. (2004) Differential Signaling Pathways Are Activated in the Epstein-Barr Virus-Associated Malignancies Nasopharyngeal Carcinoma and Hodgkin Lymphoma. Cancer Res, 64, 5251-5260. https://doi.org/10.1158/0008-5472.CAN-04-0538

[9]   He, X.C., Yin, T., Grindley, J.C., et al. (2007) PTEN-Deficient Intestinal Stem Cells Initiate Intestinal Polyposis. Nat Genet, 39, 189-198. https://doi.org/10.1038/ng1928

[10]   Koul, D., Shen, R., Bergh, S., et al. (2006) Inhibition of AKt Survival Pathway by a Small-Molecule Inhibitor in Human Glioblastoma. Mol Cancer Ther, 5, 637-644. https://doi.org/10.1158/1535-7163.mct-05-0453

[11]   Ba Va, J. and Nath, K.A. (1995) Endothelial Cell Heme Oxygenase and Ferritininduction in Ratlung by Hemoglobin in Vivo. Am J Physiol, 268, L321-L327.

[12]   Hartmann, W., Digon Sontgerath, B., Koch, A., et al. (2006) Phosphatidylinositol 3’-Kinase/AKT Signaling Is Activated in MB Cell Proliferation and Is Associated with Reduced Expression of PTEN. Clin Cancer Res, 12, 3019-3027. https://doi.org/10.1158/1078-0432.CCR-05-2187

[13]   Yamamoto, H., Kishida, S., Kishida, M., et al. (1999) Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability. Biol Chem, 274, 10681-10684. https://doi.org/10.1074/jbc.274.16.10681

[14]   Ellison, D.W., Onilude, O.E., Lindsey, J.C., et al. (2005) Β-Catenin Status Predicts a Favorable Outcome in Childhood MB: The United Kingdom Children’s Cancer Study Group Brain Tumor Committee. Journal of Clinical Oncology, 23, 7951-7957. https://doi.org/10.1200/JCO.2005.01.5479

[15]   Dejana, E., Orsenigo, F. and Lampugnani, M.G. (2008) The Role of Adherent Junction and VE-Cadherin in the Control of Vascular Permeability. J Cell Sci, 121, 2115-2122. https://doi.org/10.1242/jcs.017897

 
 
Top