NM  Vol.2 No.3 , September 2011
Electroencephalographic Abnormalities in Patients with Idiopathic Insomnia
ABSTRACT
Objective: The main goal of the present research is to describe the electroencephalographic activity during sleep and the cyclic alternating pattern (CAP) on idiopathic insomniac patients. Methods: 22 idiopathic insomnia patients were included. Sleep recording included: fully conventional EEG recording (32 electrodes, with 16 channels getting ipsilateral bipolar recordings), EOG, EMG, EKG, thoracic and abdominal respiratory movements, nasal flow and oximetry. Results: Out of the 22 registered patients, 10 (45%) showed no electroencephalographic alteration, while 12 (55%) exhibited an electroencephalographic alteration (irritative activity). Concerning PSG variables, significant differences between groups (no EEG alteration and EEG alterations) were detected in: sleep latency, total sleep time, total wake time, sleep efficiency, light sleep percentage, slow waves sleep percentage and on the sub type A1 index of the cyclic alternant pattern CAP. Conclusions: The present data strongly suggest that within the population diagnosed with idiopathic insomnia, there is a subgroup in which the electroencephalographic alterations may play a critical role as the source of the sleep abnormality.

Cite this paper
nullD. Lechuga, O. Escandón, M. Corona, C. Montoya, G. R., A. Anguiano, O. García and J. Moctezuma, "Electroencephalographic Abnormalities in Patients with Idiopathic Insomnia," Neuroscience and Medicine, Vol. 2 No. 3, 2011, pp. 178-184. doi: 10.4236/nm.2011.23024.
References
[1]   J. Edinger, R. Bootzin, D. Buysse, C. Espie, L. Lack, C. Morin, D. Riemann, A. Spilman, E. Stepanski, Wohlgemuth W. Insom-nia. “The International Classification of Sleep Disorders. Diag-nostic and Coding Manual,” 2nd Edition, Westchester, Illinois, 2005. pp. 1-31.

[2]   D. J. Taylor, K. L. Lichstein and H. H. Durrence, “Insomnia as a Health Risk Factor,” Behavioral Sleep Medicine, Vol. 1, No. 4, 2003, pp. 227-247. doi:10.1207/S15402010BSM0104_5

[3]   M. M. Weissman, S. Greenwald, G. Ni?o-Murcia and W. C. Dement, “The Morbidity of Insomnia Uncomplicated By Psy-chiatric Disorders,” General Hospital Psychiatry, Vol. 19, No. 4, July 1997, pp. 245-250. doi:10.1016/S0163-8343(97)00056-X

[4]   Z. De Saint Hilaire, J. Straub and A. Pelissolo, “Temperament and Character in Primary Insomnia,” European Psychiatry, Vol. 20, No. 2, 2005, pp. 188-192. doi:10.1016/j.eurpsy.2004.04.009

[5]   “Diagnostic and Statistical Manual of Mental Disorders,” The American Psychiatric Association, 1980.

[6]   M. G. Terzano, L. Parrino, M. C. Spaggiari, V. Palomba, M. Rossi, A. Smerieri, “CAP Variables and Arousals as Sleep Elec-troencephalogram Markers for Primary Insomnia,” Clinical Neurophysiology, Vol. 114, No. 9, September 2003, pp. 1715-1723.

[7]   M. H. Bonnet and D. L. Arand, “The Consequences of a Week of Insomnia,” Sleep, Vol. 19, No. 6, July 1996, pp. 453-461.

[8]   P. A. Lanfranchi, M. H. Pennestri, L. Fradette, M. Du- mont, C. M. Morin and J. Montplaisir, “Nighttime Blood Pressure in Normotensive Subjects with Chronic Insomnia: Implications for Cardiovascular Risk,” Sleep, Vol. 32, No. 6, 1 June 2009, pp. 760-766.

[9]   Personal Communication, Jimenez Correa U, 2008.

[10]   M. Terzano, L. Parrino, A. Smerieria, R. Chervinb, S. Chok-rovertyc, C. Guilleminaut, et al., “Atlas, Rules, And Recording Techniques for the Scoring of Cyclic Alternating Pattern (CAP) in Human Sleep,” Sleep Medicine Vol. 3, No. 2, 2002, pp. 187-199. doi:10.1016/S1389-9457(02)00003-5

[11]   M. Terzano, L. Parrino, M. Sapaggiari, V. Palomba, M. Rossi and A. Smerieri, “CAP Variables and Arousals as Sleep Elec-troencephalogram Markers for Primary Insomnia,” Clinical Neurophysiology, Vol. 114, No. 9, September 2003, pp. 1715-1723.

[12]   Standards of Practice Committee of the American Sleep Disor-ders Association Practice parameters for the Use of Polysom-nography in the Evaluation of Insomnia, 1995.

[13]   D. J. Buysse, A. Germain, M. L. Hall, D. E. Moul, E. A. Nofz-inger, A. Begley, C. L. Ehlers, W. Thompson and D. J. Kupfer, “EEG Spectral Analysis in Primary Insomnia: NREM Period Effects and Sex Differences,” Sleep,; Vol. 31, No. 12, 1 De-cember 2008, pp. 1673-1682.

[14]   M. L. Perlis, H. Merica, M. T. Smith and D. E. Giles, “Beta EEG Activity and Insomnia,” Sleep Med. Rev, Vol. 5, No. 5, 2001, pp. 365-376. doi:10.1053/smrv.2001.0151

[15]   K. Adam, M. Tomeny and I. Oswald, “Physiological and Psy-chological Differences between Good and Poor Sleepers,” Journal of Psychiatric Research, Vol. 20, No. 4, 1986, pp. 301-316. doi:10.1016/0022-3956(86)90033-6

[16]   E. A. Nofzinger, D. J. Buysse, A. Germain, et al., “Functional Neuroimaging Evidence for Hyperarousal in Insomnia,” The American Journal of Psychiatry, Vol. 161, No. 11, 2004, pp. 2126-2128. doi:10.1176/appi.ajp.161.11.2126

[17]   A. Rechtschaffen and A. Kales, “A Manual of Standardized Terminology: Techniques and Scoring System of Sleep Stages of Human Subjects,” UCLA Brain Information Service/Brain Research Institute, Los Angeles, California, 1968.

[18]   The American Academy of Sleep Medicine, “Rules, Terminol-ogy and Technical Specifications,” Westchester, 2007.

[19]   L. Van Houdenhove, B. Buyse, L. Gabri?ls, I. Van Diest and O. Van Den Bergh, “Cognitive-Behavioral Therapy for Primary Insomnia: Effectiveness in a Clinical Setting,” Tijdschrift voor Psychiatrie, Vol. 52, No. 2, 2010, pp. 79- 88.

[20]   Buysse, D. J. y Reynolds, C. F., “Insomnia,” In: M. J. Thorpy, Ed., Handbook of Sleep Disorders, Marcel Dekker Inc., New York, 1990, pp. 373-434.

[21]   M. E. Klink, S. F. Quan, W. T. Kaltembom and M. D. Lebowitz, “Risk Factor Associated with Complaints of Insomnia in a General Adult Population. Influence of Previous Complaints of Insomnia,” Archives of Internal Medicine, Vol. 152, No. 8, 1992, pp. 1634-1637. doi:10.1001/archinte.152.8.1634

 
 
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