AiM  Vol.6 No.14 , December 2016
A Review of the Ubiquity of Ascomycetes Filamentous Fungi in Relation to Their Economic and Medical Importance
Abstract: Filamentous fungi are found in different habitats in the environment including, air, water and soil. This group of fungi contains organisms from different classes under the sub-phylum Pezizomycotina. They occur in mixtures such that you find many genera of filamentous fungi dominating a particular habitat or substrate. The wide distribution of filamentous fungi has resulted in it being used for different purposes. This review aims to analyse the different genera of fungi species referred to as filamentous fungi and their relevance economically and medically.
Cite this paper: Augustina Egbuta, M. , Mwanza, M. and Oluranti Babalola, O. (2016) A Review of the Ubiquity of Ascomycetes Filamentous Fungi in Relation to Their Economic and Medical Importance. Advances in Microbiology, 6, 1140-1158. doi: 10.4236/aim.2016.614103.

[1]   Pitt, J.I., Samson, R.A. and Frisvad, J.C. (2000) List of Accepted Species and Their Synonyms in the Family Trichocomaceae. In: Samson, R.A. and Pitt, J.I., Eds., Integration of Modern Taxonomic Methods for Penicillium and Aspergillus Classification, Harwood, Amsterdam, 9-49.

[2]   Kirk, P.M., Cannon, P.F., Minter, D.W. and Stalpers, J.A. (2008) Dictionary of the Fungi. CSIRO Publishing, Australia.

[3]   Bennett, J.W. (1998) Mycotechnology: The Role of Fungi in Biotechnology. Journal of Biotechnology, 66, 101-107.

[4]   Bennett, J.W. and Klich, M. (2009) Mycotoxins. In: Schaechter, M., Ed., Encyclopedia of Microbiology, 3rd Edition, Academic Press, Oxford, 559-565.

[5]   Sauer, M., Porro, D., Mattanovich, D. and Branduardi, P. (2008) Microbial Production of Organic Acids: Expanding the Markets. Trends in Biotechnology, 26, 100-108.

[6]   Ward, O.P. (2012) Production of Recombinant Proteins by Filamentous Fungi. Journal of Biotechnology Advances, 30, 1119-1139.

[7]   Moretti, A.N. (2009) Taxonomy of Fusarium Genus, a Continuous Fight between Lumpers and Splitters. Proceedings of the National Academy of Sciences, 117, 7-13.

[8]   Pitt, J.I. and Hocking, A.D. (1997) Primary Keys and Miscellaneous Fungi. Fungi and Food Spoilage, 2nd Edition, Blackie Academic and Professional, London, Weinheim, New York, Tokyo, Melbourne, Madras, 59-171.

[9]   Barkai-Golan, R. (2008) Chapter 6—Aspergillus Mycotoxins. In: Rivka, B.-G. and Nachman, P., Eds., Mycotoxins in Fruits and Vegetables, Academic Press, San Diego, 115-151.

[10]   Klich, M.A. (2002) Introduction; Economic and Medical Importance of Aspergillus. Identification of Common Aspergillus Species, Centraalbureau voor Schimmelculture, Utrecht, 1-16.

[11]   Leslie, J.F. and Summerell, B.A. (2006) The Fusarium Laboratory Manual. Blackwell Publishing, Hoboken, 1-2.

[12]   Pitt, J.I. and Hocking, A.D. (1997) Primary Keys and Miscellaneous Fungi. In: Pitt, J.I. and Hocking, A.D., Eds., Fungi and Food Spoilage, 2nd Edition, Blackie Academic and Professional, London, 59-171.

[13]   Nucci, M. and Anaissie, E. (2007) Fusarium Infections in Immunocompromised Patients. Clinical Microbiology Reviews, 20, 695-704.

[14]   Howard, D.H. (2003) Pathogenic Fungi in Humans and Animals. 2nd Edition, Marcel Dekker Inc., New York, 237-430.

[15]   Rivas, S. and Thomas, C.M. (2005) Molecular Interactions between Tomato and the Leaf Mold Pathogen: Cladosporium fulvum. Annual Review of Phytopathology, 43, 395-436.

[16]   Nowicki, M., Nowakowska, M., Niezgoda, A. and Kozik, E.U. (2012) Alternaria Black Spot of Crucifers: Symptoms, Importance of Disease, and Perspectives of Resistance Breeding. Vegetable Crops Research Bulletin, 76, 5-19.

[17]   Berkeley, M.J. (1857) Introduction to Cryptogamic Botany. Bailliere, London, 604.

[18]   Zalar, P., Frisvad, J.C., Gunde-Cimerman, N., Varga, J. and Samson, R.A. (2008) Four New Species of Emericella from the Mediterranean Region of Europe. Mycologia, 100, 779-795.

[19]   Verweij, P.E., Varga, J., Houbraken, J., Rijs, A.J.M.M., VerduynLunel, F.M., Blijlevens, N.M.A., Shea, Y.R., Holland, S.M., Warris, A., Melchers, W.J.G. and Samson, R.A. (2008) Emericella quadrilineata as Cause of Invasive Aspergillosis. Emerging Infectious Diseases, 14, 566-572.

[20]   Matsuzawa, T., Tanaka, R., Horie, Y., Gonoi, T. and Yaguchi, T. (2010) Development of Rapid and Specific Molecular Discrimination Methods for Pathogenic Emericella Species. Nippon Ishinkin Gakkai Zasshi, 51, 109-116.

[21]   Butinar, L., Zalar, P., Frisvad, J.C. and Gunde-Cimerman, N. (2005) The Genus Eurotium – Members of Indigenous Fungal Community in Hypersaline Waters of Salterns. FEMS Microbiology Ecology, 51, 155-166.

[22]   Hubka, V., Kolarík, M., Kubátová, A. and Peterson, S.W. (2013) Taxonomic Revision of Eurotium and Transfer of Species to Aspergillus. Mycologia, 105, 912-937.

[23]   Inglis, P.W. and Tigano, M.S. (2006) Identification and Taxonomy of Some Entomopathogenic Paecilomyces spp. (Ascomycota) Isolates Using rDNA-ITS Sequences. Genetics and Molecular Biology, 29, 132-136.

[24]   Steiner, B., Aquino, V.R., Paz, A.A., Silla, L.M.d.R., Zavascki, A. and Goldani, L.Z. (2013) Paecilomyces variotii as an Emergent Pathogenic Agent of Pneumonia. Case Reports in Infectious Diseases, 3.

[25]   Pastor, F.J. and Guarro, J. (2006) Clinical Manifestations, Treatment and Outcome of Paecilomyces lilacinus Infections. Clinical Microbiology and Infection, 12, 948-960.

[26]   Egbuta, M.A., Mwanza, M., Njobeh, P.B., Phoku, J.Z. and A, C.C. (2015) Isolation of Filamentous Fungi Species Contaminating Some Nigerian Food Commodities. Journal of Food Research, 4, 38-50.

[27]   Pitt, J.I. and Hocking, A.D. (1997) Fungi and Mycotoxins in Foods. In: Orchard, A.E., Ed., Fungi of Australia, Vol. 1, Introduction Fungi in the Environment, Australian Biology Research Study, Canberra, Australia, 315-342.

[28]   Watanabe, T., Watanabe, Y. and Fukatsu, T. (2001) New Species of Acremonium, Cylindrocarpon and Verticillium from Soil in the Bonin (Ogasawara) Islands, Japan. Mycoscience, 42, 591-595.

[29]   Goldbeck, R., Ramos, M.M., Pereira, G.A.G. and Maugeri-Filho, F. (2013) Cellulase Production from a New Strain Acremonium strictum Isolated from the Brazilian Biome Using Different Substrates. Bioresource Technology, 128, 797-803.

[30]   Pastor, F.J. and Guarro, J. (2008) Alternaria Infections: Laboratory Diagnosis and Relevant Clinical Features. Clinical Microbiology and Infection, 14, 734-746.

[31]   Arvanitidou, M., Kanellou, K., Constantinidis, T. and Katsouyannopoulos, V. (2000) Higher Prevalence of Alternaria spp. in Marine and River Waters than in Potable Samples. Microbiological Research, 155, 49-51.

[32]   Horn, B.W. and Dorner, J.W. (1998) Soil Populations of Aspergillus Species from Section Flavi along a Transect through Peanut-Growing Regions of the United States. Mycologia, 90, 767-776.

[33]   Klich, M.A. (2002) Biogeography of Aspergillus Species in Soil and Litter. Mycologia, 94, 21-27.

[34]   Klich, M.A. (2002) Identification of Common Aspergillus spp, Ponson and Looijen, Wageningen. The Netherlands.

[35]   Oliveira, L.G., Cavalcanti, M.A.Q., Fernandes, M.J.S. and Lima, D.M.M. (2013) Diversity of Filamentous Fungi Isolated from the Soil in the Semiarid Area, Pernambuco, Brazil. Journal of Arid Environments, 95, 49-54.

[36]   Khan, H.A.A. and Karuppayil, M.S. (2012) Fungal Pollution of Indoor Environments and Its Management. Saudi Journal of Biological Sciences, 19, 405-426.

[37]   Panagopoulou, P., Filioti, J., Petrikkos, G., Giakouppi, P., Anatoliotaki, M., Farmaki, E., Kanta, A., Apostolakou, H., Avlami, A., Samonis, G. and Roilides, E. (2002) Environmental Surveillance of Filamentous Fungi in Three Tertiary Care Hospitals in Greece. Journal of Hospital Infection, 52, 185-191.

[38]   Nikaeen, M. and Mirhendi, H. (2008) Inactivation of Aspergillus flavus Spores in Water by Ultraviolet Irradiation. World Applied Sciences Journal, 4, 594-595.

[39]   Vesper, S.J., Haugland, R.A., Rogers, M.E. and Neely, A.N. (2007) Opportunistic Aspergillus Pathogens Measured in Home and Hospital Water by Quantitative PCR. Journal of Water Health, 5, 427-431.

[40]   Warris, A., Voss, A., Abrahamsen, T.G. and Verweij, P.E. (2002) Contamination of Hospital Water with Aspergillus fumigatus and Other Molds. Clinical Infectious Diseases, 34, 1059-1060.

[41]   Zalar, P., de Hoog, G., Schroers, H., Crous, P., Groenewald, J. and Gunde-Cimerman, N. (2007) Phylogeny and Ecology of the Ubiquitous Saprobe Cladosporium sphaerospermum, with Descriptions of Seven New Species from Hypersaline Environments. Studies in Mycology, 58, 157-183.

[42]   Ogórek, R., Lejman, A., Pusz, W., Miluch, A. and Miodyńska, P. (2012) Characteristics and Taxonomy of Cladosporium Fungi. Mikologia Lekarska, 19, 80-85.

[43]   Pratt, R.G. (2006) Comparative Survival of Conidia of Eight Species of Bipolaris, Curvularia, and Exserohilum in Soil and Influences of Swine Waste Amendments on Survival. Applied Soil Ecology, 31, 159-168.

[44]   Wang, H., Dong, H., Qian, H. and Cong, B. (2014) Laboratory Assessment of Entomopathogenic Nematode Symbiotic Bacteria to Control Maize Pest, Ostrinia furnacalis, and Fungi Diseases, Bipolaris maydis and Curvularia lunata. Journal of Asia-Pacific Entomology, 17, 823-827.

[45]   Lucas, E.M.F., Abreu, L.M., Marriel, I.E., Pfenning, L.H. and Takahashi, J.A. (2008) Phthalates Production from Curvularia senegalensis (Speg.) Subram, a Fungal Species Associated to Crops of Commercial Value. Microbiological Research, 163, 495-502.

[46]   Asan, A. (2011) Checklist of Fusarium Species Reported from Turkey. Mycotaxon, 116, 479.

[47]   Edel-Hermann, V., Gautheron, N., Mounier, A. and Steinberg, C. (2015) Fusarium Diversity in Soil Using a Specific Molecular Approach and a Cultural Approach. Journal of Microbiological Methods, 111, 64-71.

[48]   Gordon, T.R. and Martyn, R.D. (1997) The Evolutionary Biology of Fusarium oxysporum. Annual Review Phytopathology, 35, 111-128.

[49]   Gordon, T.R., Swett, C.L. and Wingfield, M.J. (2015) Management of Fusarium Diseases Affecting Conifers. Crop Protection, 73, 28-39.

[50]   Funnell-Harris, D.L. and Pedersen, J.F. (2011) Presence of Fusarium spp. in Air and Soil Associated with Sorghum Fields. Plant Disease, 95, 648-656.

[51]   Scheel, C., Hurst, S., Barreiros, G., Akiti, T., Nucci, M. and Balajee, S.A. (2013) Molecular Analyses of Fusarium Isolates Recovered from a Cluster of Invasive Mold Infections in a Brazilian Hospital. BMC Infectious Diseases, 13, 49.

[52]   Vigier, B., Reid, L.M., Seifert, K.A., Stewart, D.W. and Hamilton, R.I. (1997) Distribution and Prediction of Fusarium Species Associated with Maize Ear Rot in Ontario. Canadian Journal of Plant Pathology, 19, 60-65.

[53]   Palmero, D., Iglesias, C., de Cara, M., Lomas, T., Santos, M. and Tello, J.C. (2009) Species of Fusarium Isolated from River and Sea Water of Southeastern Spain and Pathogenicity on Four Plant Species. Plant Disease, 93, 377-385.

[54]   Sautour, M., Edel-Hermann, V., Steinberg, C., Sixt, N., Laurent, J., Dalle, F., Aho, S., Hartemann, P., L’Ollivier, C., Goyer, M. and Bonnin, A. (2012) Fusarium Species Recovered from the Water Distribution System of a French University Hospital. International Journal of Hygiene and Environmental Health, 215, 286-292.

[55]   Jussila, J., Komulainen, H., Kosma, V.-M., Pelkonen, J. and Hirvonen, M.-R. (2002) Inflammatory Potential of the Spores of Penicillium spinulosum Isolated from Indoor Air of a Moisture-Damaged Building in Mouse Lungs. Environmental Toxicology and Pharmacology, 12, 137-145.

[56]   Sawane, A. and Saoji, A. (2004) A Report on Penicillium in the Intramural and Extramural Air of Residential Areas of Nagpur city (India). Aerobiologia, 20, 229-236.

[57]   Cruz, R., Santos, C., Silva de Lima, J., Aparecida Moreira, K. and Maria de Souza-Motta, C. (2013) Diversity of Penicillium in Soil of Caatinga and Atlantic Forest Areas of Pernambuco, Brazil: An Ecological Approach. Nova Hedwigia, 97, 543-556.

[58]   Dayalan, S.A.J., Darwin, P. and Prakash, S. (2011) Comparative Study on Production, Purification of Penicillin by Penicillium chrysogenum Isolated from Soil and Citrus Samples. Asian Pacific Journal of Tropical Biomedicine, 1, 15-19.

[59]   Pryce-Miller, E., Aanensen, D., Vanittanakom, N. and Fisher, M.C. (2008) Environmental Detection of Penicillium marneffei and Growth in Soil Microcosms in Competition with Talaromyces stipitatus. Fungal Ecology, 1, 49-56.

[60]   Trisuwan, K., Rukachaisirikul, V., Borwornwiriyapan, K., Phongpaichit, S. and Sakayaroj, J. (2014) Benzopyranone, Benzophenone, and Xanthone Derivatives from the Soil Fungus Penicillium citrinum PSU-RSPG95. Tetrahedron Letters, 55, 1336-1338.

[61]   Tarkkanen, A., Raivio, V., Anttila, V.-J., Tommila, P., Ralli, R., Merenmies, L. and Immonen, I. (2004) Fungal Endophthalmitis Caused by Paecilomyces variotii Following Cataract Surgery: A Presumed Operating Room Air-Conditioning System Contamination. Acta Ophthalmologica Scandinavica, 82, 232-235.

[62]   Luangsa-ard, J., Houbraken, J., van Doorn, T., Hong, S.-B., Borman, A.M., Hywel-Jones, N.L. and Samson, R.A. (2011) Purpureocillium, a New Genus for the Medically Important Paecilomyces lilacinus. FEMS Microbiology Letters, 321, 141-149.

[63]   Ogorek, R., Pusz, W., Matkowski, K. and Plaskowska, E. (2014) Assessment of Abundance and Species Composition of Filamentous Fungi in the Underground Rzeczka Complex in Sowie Mountains (Lower Silesia, Poland). Geomicrobiology Journal, 31, 900-906.

[64]   Karwowska, W., Pierzynowska, J., Janicki, A., Waszkiewicz-Robak, B. and Przybylska, A. (2004) Qualitative and Quantitative Analysis of Filamentous Fungi in Air, Food and Ochratoxin a in Human Milk. Polish Journal of Food and Nutrition Sciences, 13/54, 41-44.

[65]   Viegas, C., Alves, C.L., Carolino, E., Rosado, L. and Santos, C.S. (2010) Prevalence of Fungi in Indoor Air with Reference to Gymnasiums with Swimming Pools. Indoor and Built Environment, 19, 555-561.

[66]   Panagopoulou, P., Filioti, J., Farmaki, E., Maloukou, A. and Roilides, E. (2007) Filamentous Fungi in a Tertiary Care Hospital: Environmental Surveillance and Susceptibility to Antifungal Drugs. Infection Control and Hospital Epidemiology, 28, 60-67.

[67]   Ritz, K. and Young, I.M. (2004) Interactions between Soil Structure and Fungi. Mycologist, 18, 52-59.

[68]   Kurek, E., Teresa Kornillowicz-Kowalska, T., Slomka, A. and Melke, J. (2007) Characteristics of Soil Filamentous Fungi Communities Isolated from Various Micro-Relief Forms in the High Arctic Tundra (Bellsund Region, Spitsbergen). Polish Polar Research, 28, 57-73.

[69]   Hughes, K.A., Bridge, P. and Clark, M.S. (2007) Tolerance of Antarctic Soil Fungi to Hydrocarbons. Science of the Total Environment, 372, 539-548.

[70]   Sterflinger, K., Tesei, D. and Zakharova, K. (2012) Fungi in Hot and Cold Deserts with Particular Reference to Microcolonial Fungi. Fungal Ecology, 5, 453-462.

[71]   Gonçalves, A.B., Paterson, R.R.M. and Lima, N. (2006) Survey and Significance of Filamentous Fungi from Tap Water. International Journal of Hygiene and Environmental Health, 209, 257-264.

[72]   Paterson, R.R.M., Hageskal, G., Skaar, I. and Lima, N. (2009) Occurrence, Problems, Analysis and Removal of Filamentous Fungi in Drinking Water. In: De Costa, P.A.B. and Bezerra, P., Eds., Fungicides: Chemistry, Environmental Impacts and Health Effects, Nova Science Publishers Inc., New York, 379-399.

[73]   Sonigo, P., De Toni, A. and Reilly, K. (2011) A Review of Fungi in Drinking Water and the Implications for Human Health. BIO Intelligence Service, France.

[74]   Hayette, M.P., Christiaens, G., Mutsers, J., Barbier, C., Huynen, P., Melin, P. and de Mol, P. (2010) Filamentous Fungi Recovered from the Water Distribution System of a Belgian University Hospital. Medical Mycology, 48, 969-974.

[75]   Yamaguchi, M.U., Rampazzo, R., Yamada-Ogatta, S.F., Nakamura, C.V., Ueda-Nakamura, T. and Dias Filho, B.P. (2007) Yeasts and Filamentous Fungi in Bottled Mineral Water and Tap Water from Municipal Supplies. Brazilian Archives of Biology and Technology, 50, 1-9.

[76]   Warris, A., Gaustad, P., Meis, J.F., Voss, A., Verweij, P.E. and Abrahamsen, T.G. (2001) Recovery of Filamentous Fungi from Water in a Paediatric Bone Marrow Transplantation Unit. Journal of Hospital Infection, 47, 143-148.

[77]   Okpako, E.C., Osuagwu, A.N., Duke, A.E. and Ntui, V.O. (2009) Prevalence and Significance of Fungi in Sachet and Borehole Drinking Water in Calabar, Nigeria. African Journal of Microbiological Research, 3, 56-61.

[78]   Mohamed, S.A., Hamed, S.R. and Al-Wasify, R.S. (2014) Relative Diversity of Filamentous Fungi and Yeasts in Groundwater and Their Correlation to Fecal Pollution Indicators and Physicochemical Parameters. International Journal of Current Microbiology and Applied Sciences, 3, 905-919.

[79]   Mbata, T.I. (2008) Isolation of Fungi in Hyper Saline Dead Sea Water. Sudanese Journal of Public Health, 3, 170-172.

[80]   Varo, S., Martins, C.H., Cardoso, M.J., Sartori, F.G., Montanari, L.B. and Pires-Goncalves, R.H. (2007) [Isolation of Filamentous Fungi from Water Used in a Hemodialysis Unit. Revista da Sociedade Brasileira de Medicina Tropical, 40, 326-331.

[81]   Schuster, E., Dunn-Coleman, N., Frisvad, J.C. and van Dijck, P.W.M. (2002) On the Safety of Aspergillus niger—A Review. Applied Microbiology and Biotechnology, 59, 426-435.

[82]   Michelson, P. (2010) Cheese: Exploring Taste and Tradition.

[83]   Van der Straat, L., Vernooij, M., Lammers, M., van den Berg, W., Schonewille, T., Cordewener, J., van der Meer, I., Koops, A. and de Graaff, L.H. (2014) Expression of the Aspergillus terreus Itaconic Acid Biosynthesis Cluster in Aspergillus niger. Microbial Cell Factories, 13, 11.

[84]   Romero, C.M., Urrutia, I.M., Reinoso, E.H. and Kiernan, M.M. (2010) Benzo[a]Pyrene Degradation by Soil Filamentous Fungi. Journal of Yeast and Fungal Research, 1, 25-29.

[85]   Kurniati, E., Arfarita, N., Imai, T., Higuchi, T., Kanno, A., Yamamoto, K. and Sekine, M. (2014) Potential Bioremediation of Mercury-Contaminated Substrate Using Filamentous Fungi Isolated from Forest Soil. Journal of Environmental Sciences, 26, 1223-1231.

[86]   Ogawa, A., Morita, Y., Tanaka, T., Sakiyama, T. and Nakanishi, K. (1995) Production of Kojic Acid from Aspergillus oryzae var.oryzae by Membrane-Surface Liquid Culture. Biotechnology Techniques, 9, 153-156.

[87]   Jahromi, M.F., Liang, J.B., Ho, Y.W., Mohamad, R., Goh, Y.M. and Shokryazdan, P. (2012) Lovastatin Production byAspergillus terreus Using Agro-Biomass as Substrate in Solid State Fermentation. Journal of Biomedicine and Biotechnology, 2012, Article ID: 196264.

[88]   Katona, S.J. (2002) Sensitivity to Quorn Mycoprotein (Fusarium venenatum) in a Mould Allergic Patient. Journal of Clinical Pathology, 55, 876-877.

[89]   Kaur, R., Kaur, J. and Singh, R.S. (2010) Nonpathogenic Fusarium as a Biological Control Agent. Plant Pathology Journal, 9, 79-91.

[90]   Ahmed, H., Strub, C., Hilaire, F. and Schorr-Galindo, S. (2015) First Report: Penicillium adametzioides, a Potential Biocontrol Agent for Ochratoxin-Producing Fungus in Grapes, Resulting from Natural Product Pre-Harvest Treatment. Food Control, 51, 23-30.

[91]   Frisvad, J.C., Smedsgaard, J., Larsen, T.O. and Samson, R.A. (2004) Mycotoxins, Drugs and Other Extrolites Produced by Species in Penicillium Subgenus Penicillium. Studies in Mycology, 49, 201-241.

[92]   Barthomeuf, C., Regerat, F. and Pourrat, H. (1991) Production of Inulinase by a New Mold Penicillium rugulosum. Journal of Fermentation and Bioengineering, 72, 491-494.

[93]   Laich, F., Fierro, F. and Martin, J.F. (2002) Production of Penicillin by Fungi Growing on Food Products: Identification of a Complete Penicillin Gene Cluster in Penicillium griseofulvum and a Truncated Cluster in Penicillium verrucosum. Applied and Environmental Microbiology, 68, 1211-1219.

[94]   Sahasrabudhe, N.A., Lackhe, A.H. and Ranjekar, P.K. (1987) Characterization of the Purified Multifunctional Cellulase Component of P. funiculosum. FEMS Microbiology Letters, 40, 315-319.

[95]   Nelson, J.H. (1970) Production of Blue Cheese Flavor via Submerged Ermentation by Penicillium roqueforti. Journal of Agriculture and Food Chemistry, 18, 567-569.

[96]   D’Annibale, A., Rosetto, F., Leonardi, V., Federici, F. and Petruccioli, M. (2006) Role of Autochthonous Filamentous Fungi in Bioremediation of a Soil Historically Contaminated with Aromatic Hydrocarbons. Applied and Environmental Microbiology, 72, 28-36.

[97]   Mancera-López, M.E., Esparza-García, F., Chávez-Gómez, B., Rodríguez-Vázquez, R., Saucedo-Castaneda, G. and Barrera-Cortés, J. (2008) Bioremediation of an Aged Hydrocarbon-Contaminated Soil by a Combined System of Biostimulation-Bioaugmentation with Filamentous Fungi. International Biodeterioration & Biodegradation, 61, 151-160.

[98]   Potin, O., Rafin, C. and Veignie, E. (2004) Bioremediation of an Aged Polycyclic Aromatic Hydrocarbons (PAHs)-Contaminated Soil by Filamentous Fungi Isolated from the Soil. International Biodeterioration & Biodegradation, 54, 45-52.

[99]   Abbas, H.K., Weaver, M.A., Horn, B.W., Carbone, I., Monacell, J.T. and Shier, W.T. (2011) Selection of Aspergillus flavus Isolates for Biological Control of Aflatoxins in Corn. Toxin Reviews, 30, 59-70.

[100]   Zheng, Y., Yu, X., Zeng, J. and Chen, S. (2012) Feasibility of Filamentous Fungi for Biofuel Production Using Hydrolysate from Dilute Sulfuric Acid Pretreatment of Wheat Straw. Biotechnology for Biofuels, 5, 1-10.

[101]   Dutton, M.F. (2009) The African Fusarium/Maize Disease. Mycotoxin Research, 25, 29-39.

[102]   Perrone, G., Susca, A., Cozzi, G., Ehrlich, K., Varga, J., Frisvad, J.C., Meijer, M., Noonim, P., Mahakarnchanakul, W. and Samson, R.A. (2007) Biodiversity of Aspergillus Species in Some Important Agricultural Products. Studies in Mycology, 59, 53-66.

[103]   Zain, M.E. (2011) Impact of Mycotoxins on Humans and Animals. Journal of Saudi Chemical Society, 15, 129-144.

[104]   Jerusik, R.J. (2010) Fungi and Paper Manufacture. Fungal Biology Reviews, 24, 68-72.

[105]   Mohammad, N., Alam, M.Z., Kabbashi, N.A. and Ahsan, A. (2012) Effective Composting of Oil Palm Industrial Waste by Filamentous Fungi: A Review. Resources, Conservation and Recycling, 58, 69-78.

[106]   Khokhar, I., HAIDER, M.S., Mushtaq, S. and Mukhtar, I. (2012) Isolation and Screening of Highly Cellulolytic Filamentous Fungi. Journal of Applied Sciences and Environmental Management, 16, 223-226.

[107]   Archer, D.B. (2000) Filamentous Fungi as Microbial Cell Factories for Food Use. Current Opinion in Biotechnology, 11, 478-483.

[108]   Guimarães, L., Peixoto-Nogueira, S., Michelin, M., Rizzatti, A., Sandrim, V.C., Zanoelo, F.F., Aquino, A., Altino, B and Polizeli, M. (2006) Screening of Filamentous Fungi for Production of Enzymes of Biotechnological Interest. Brazilian Journal of Microbiology, 37, 474-480.

[109]   Majumder, L., Khalil, I., Munshi, M.K., Alam, K., Rashid, H.-O., Begum, R. and Alam, N. (2010) Citric Acid Production by Aspergillus niger Using Molasses and Pumpkin as Substrates. European Journal of Biological Sciences, 2, 1-8.

[110]   Max, B., Salgado, J.M., Rodríguez, N., Cortés, S., Converti, A. and Domínguez, J.M. (2010) Biotechnological Production of Citric acid. Brazilian Journal of Microbiology, 41, 862-875.

[111]   Sahasrabudhe, N.A. and Sankpal, N.V. (2001) Production of Organic Acids and Metabolites of Fungi for Food Industry. In: George, G.K. and Dilip, K.A., Eds., Applied Mycology and Biotechnology, Elsevier, Amsterdam, 387-425.

[112]   Goswami, S., Vidyarthi, A.S., Bhunia, B. and Mandal, T. (2012) A Review on Lovastatin and Its Production. Journal of Biochemical Technology, 4, 581-587.

[113]   Manzoni, M. and Rollini, M. (2002) Biosynthesis and Biotechnological Production of Statins by Filamentous Fungi and Application of These Cholesterol-Lowering Drugs. Applied Microbiology and Biotechnology, 58, 555-564.

[114]   McLean, K.J., Hans, M., Meijrink, B., van Scheppingen, W.B., Vollebregt, A., Tee, K.L., van der Laan, J.-M., Leys, D., Munro, A.W. and van den Berg, M.A. (2015) Single-Step Fermentative Production of the Cholesterol Lowering Drug Pravastatin via Reprogramming of Penicillium chrysogenum. Proceedings of the National Academy of Sciences of the United States of America, 112, 2847-2852.

[115]   Sharmila, K., Thillaimaharani, K.A., Logesh, A.R., Sathishkumar, A. and Kalaiselvam, M. (2012) Production of Cyclosporin—A by Saprophytic Filamentous Fungus Fusarium oxysporum. International Journal of Pharmacy and Pharmaceutical Sciences, 4, 149-153.

[116]   He, H., Yang, H.Y., Bigelis, R., Solum, E.H., Greenstein, M. and Carter, G.T. (2002) Pyrrocidines A and B, New Antibiotics Produced by a Filamentous Fungus. Tetrahedron Letters, 43, 1633-1636.

[117]   Goswami, S., Rani, A., Priyadarshini, R., Bhunia, B. and Mandal, T. (2012) A Review on Production of Echinocandins by Aspergillus sp. Journal of Biochemical Technology, 4, 568-575.

[118]   Svahn, S.K., Goransson, U., El-Seedi, H., Bohlin, L., Larsson, J.D.G., Olsen, B. and Chryssanthou, E. (2012) Antimicrobial Activity of Filamentous Fungi Isolated from Highly Antibiotic Contaminated River Sediment. Infection Ecology and Epidemiology, 2, 11591-11597.

[119]   Smith, H.A. (2014) Production of Antimicrobials and Antioxidants from Filamentous Fungi. Department of Biology, National University of Ireland, Ireland.

[120]   Amadio, J., Casey, E. and Murphy, C. (2013) Filamentous Fungal Biofilm for Production of Human Drug Metabolites. Applied Microbiology and Biotechnology, 97, 5955-5963.